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CAS No. :	529-53-3
Formula :	C₁₅H₁₀O₆
M.W :	286.24
SMILES Code :	O=C1C=C(C2=CC=C(O)C=C2)OC3=C1C(O)=C(O)C(O)=C3
Synonyms :	4',5,6,7-Tetrahydroxyflavone; 6-Hydroxyapigenin
MDL No. :	MFCD00017692
InChI Key :	JVXZRQGOGOXCEC-UHFFFAOYSA-N
Pubchem ID :	5281697

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

MG63 cells	0-300 µM	48 hours	SCU significantly inhibited OS cell proliferation	Drug Des Devel Ther. 2025 Jan 6;19:51-64
143B cells	0-300 µM	48 hours	SCU significantly inhibited OS cell proliferation	Drug Des Devel Ther. 2025 Jan 6;19:51-64
BEAS-2B cells	12.5–50 µM	1 hour pretreatment followed by 24 hours LPS stimulation	Reduced intracellular ROS accumulation, inhibited NADPH oxidase activity, downregulated transcription and translation of pro-inflammatory cytokines IL-6, CCL2, and CXCL8	Antioxidants (Basel). 2024 Jun 12;13(6):710
Huh-7 cells	25, 50, 100, 150, 200 µM	24 and 48 hours	To evaluate the effect of SCU on Huh-7 cell viability, results showed SCU significantly decreased cell viability in a dose- and time-dependent manner.	Int J Mol Sci. 2021 Aug 17;22(16):8841
Hep3B cells	0, 100, 200, 300, 400, 500, 600 µM	24 hours	SCU significantly inhibited Hep3B cell proliferation and induced G2/M phase cell cycle arrest.	Nutrients. 2019 Jan 24;11(2):263
T84 cells	0, 20, 40, 60, 80 µM	24 hours	Scutellarein significantly inhibited the viability and clone formation ability of T84 cells and induced apoptosis. IC50 value was 39.6 µM.	Int J Mol Med. 2020 Apr;45(4):1059-1072
SW480 cells	0, 20, 40, 60, 80 µM	24 hours	Scutellarein significantly inhibited the viability and clone formation ability of SW480 cells and induced apoptosis. IC50 value was 40 µM.	Int J Mol Med. 2020 Apr;45(4):1059-1072
CL-40 cells	0, 20, 40, 60, 80 µM	24 hours	Scutellarein significantly inhibited the viability and clone formation ability of CL-40 cells and induced apoptosis. IC50 value was 40.9 µM.	Int J Mol Med. 2020 Apr;45(4):1059-1072
Primary rat hepatocytes	80 µM	24 hours	To investigate the protective effect of Scutellarein on THP-induced hepatotoxicity, results showed that Scutellarein significantly improved hepatocyte viability and inhibited inflammatory response.	Int J Mol Med. 2023 Jul;52(1):55
HT1080 human fibrosarcoma cells	10 and 50 µM	24 hours	To evaluate the inhibitory effect of Scutellarein on the proliferation of HT1080 cells. The results showed that Scutellarein significantly suppressed the proliferation rate of HT1080 cells.	Int J Mol Med. 2015 Jan;35(1):31-8
HT-29 cells	10 µM	24 hours	Scu attenuated the IL-1β-downregulated expression levels of E-cadherin, occludin, and ZO-1, while reduced IL-1β-upregulated IL-6 and IL-8 mRNA levels. Moreover, Scu inhibited the phosphorylation and nuclear translocation of NF-κB and suppression of NF-κB phosphorylation abolished IL-1β-disrupted epithelial barrier integrity and IL-1β-upregulated proinflammatory mediators expression in HT-29 cells.	Front Pharmacol. 2024 Oct 21;15:1479441
PC12 cells	1-100 µM	3 hours	Evaluate the protective effect of Scutellarein on H2O2-induced cytotoxicity in PC12 cells, results showed Scutellarein had significant dose-dependent protective effects.	Int J Mol Sci. 2011;12(11):8208-16
HT1080 human fibrosarcoma cells	10 and 50 µM	36 hours	To evaluate the effect of Scutellarein on the invasion of HT1080 cells. The results showed that Scutellarein significantly reduced the invasion ability of HT1080 cells.	Int J Mol Med. 2015 Jan;35(1):31-8
RAW264.7 cells	25, 50, 75 µM	48 hours	Investigate the effect of SCU on LPS-induced inflammation, finding that SCU suppresses iNOS expression in a dose-dependent manner but does not affect COX-2 expression.	Molecules. 2022 Jun 12;27(12):3782
HepG2 cells	25, 50, 100 µM	48 hours	To evaluate the effect of SCU on HepG2 cell migration and proliferation, results showed SCU significantly inhibited cell migration and proliferation, and induced G2/M phase cell cycle arrest.	Int J Mol Sci. 2021 Aug 17;22(16):8841
HaCaT cells	25, 50, 100 µM	48 hours	To evaluate the effect of SCU on HaCaT cell viability, results showed no significant effect at 25, 50, 100 μM concentrations within 48 hours.	Int J Mol Sci. 2021 Aug 17;22(16):8841
HT1080 human fibrosarcoma cells	10 and 50 µM	6 hours	To evaluate the effect of Scutellarein on the migration of HT1080 cells. The results showed that Scutellarein significantly reduced the migration ability of HT1080 cells.	Int J Mol Med. 2015 Jan;35(1):31-8
Rat liver microsomes	30 µM	90 min	To study the metabolic stability of Scutellarin in male and female rat liver microsomes. Results showed that the metabolic clearance rate (CLint) of Scutellarin was significantly higher in male rats than in female rats (P<0.01).	Acta Pharmacol Sin. 2011 May;32(5):655-63

Balb/c nude mice	HT1080 cell-induced fibrosarcoma model	Intraperitoneal injection	0.05 and 0.5 µg/g	20 days	To evaluate the inhibitory effect of Scutellarein on the development of fibrosarcoma. The results showed that Scutellarein significantly reduced the volume and weight of the tumors.	Int J Mol Med. 2015 Jan;35(1):31-8
BALB/c nude mice	Colon cancer-bearing model	Intraperitoneal injection	0.5 µg/g	Once daily for 20 days	Scutellarein significantly inhibited tumor volume and Ki-67 expression, alleviating pathological changes in tumor tissues.	Int J Mol Med. 2020 Apr;45(4):1059-1072
BALB/c nude mice	Osteosarcoma xenograft model	Intraperitoneal injection	0.5 μg/g	Every 2 days until tumor volume reached about 60 mm3	SCU significantly inhibited osteosarcoma growth	Drug Des Devel Ther. 2025 Jan 6;19:51-64
SD rats	THP-induced hepatotoxicity model	Gavage	100 mg/kg	Once a week for 6 weeks	To investigate the protective effect of Scutellarein on THP-induced hepatotoxicity, results showed that Scutellarein significantly alleviated liver inflammation and liver function damage.	Int J Mol Med. 2023 Jul;52(1):55
Rats	Middle cerebral artery occlusion (MCAO) model	Intragastric administration	100, 50, 25 mg/kg	Administered for 6 consecutive days, MCAO surgery performed on the 7th day	To evaluate the protective effect of Scutellarein on focal cerebral ischemia/reperfusion, results showed that Scutellarein dose-dependently reduced neurological deficit scores and cerebral infarction volume, with better efficacy than Scutellarin	Molecules. 2012 Sep 6;17(9):10667-74
Galleria mellonella larvae	A. baumannii infection model	Injection in the left second proleg	20 mg/kg	Administered 2 hours post-infection, monitored for at least 5 days	Scu significantly increased the survival rate of larvae by about 35%	Microb Cell Fact. 2024 Oct 8;23(1):269
ICR mice	LPS-induced acute lung injury model	Intraperitoneal injection	25, 50, 100 mg/kg	Single administration, evaluated 6 h post-LPS stimulation	Significantly reduced IL-6, CCL2, and TNF-α levels in BALF, attenuated lung pathological damage, and inhibited neutrophil infiltration	Antioxidants (Basel). 2024 Jun 12;13(6):710
Sprague-Dawley rats	Pharmacokinetic model of oral and intravenous administration of Scutellarin	Oral and intravenous	400 mg/kg (oral), 40 mg/kg (intravenous)	Single dose	To study the pharmacokinetics and excretion characteristics of Scutellarin and its metabolite Scutellarein in rats. Results showed that plasma concentrations of Scutellarin were significantly higher in female rats than in male rats (P<0.05) after oral administration, and a large amount of Scutellarin was metabolized into Scutellarein in the gastrointestinal tract and excreted in feces, leading to its extremely low oral bioavailability.	Acta Pharmacol Sin. 2011 May;32(5):655-63
C57BL/6 mice	DSS-induced colitis model	Intragastric gavage	5 mg/kg, 10 mg/kg, 20 mg/kg	Once daily for 7 days	Scu significantly decreased the DAI score, improved colon shortening, ameliorated the pathological score in DSS-treated mice with better efficacy than the positive drug, 5-aminosalicylic acid. Scu also inhibited the expression levels of cytokines (Il-1β, Tnf-α, Il-1α, Il-6, and Cxcl1) as well as barrier proteins (E-cadherin, Occludin, and ZO-1) in colon tissues of DSS mice.	Front Pharmacol. 2024 Oct 21;15:1479441

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CAS No.: 529-53-3

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CAS No.: 529-53-3

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Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

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Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	3.49mL 0.70mL 0.35mL	17.47mL 3.49mL 1.75mL	34.94mL 6.99mL 3.49mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed