Dehydrocostus Lactone ((-)-Dehydrocostus lactone) | Natural Product

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	477-43-0
Formula :	C₁₅H₁₈O₂
M.W :	230.30
SMILES Code :	O=C(C1=C)O[C@@]([H])([C@]1(CCC2=C)[H])[C@]3(C(CC[C@]32[H])=C)[H]
Synonyms :	Epiligulyl oxide; (-)-Dehydrocostus lactone
MDL No. :	MFCD00210277
InChI Key :	NETSQGRTUNRXEO-XUXIUFHCSA-N
Pubchem ID :	73174

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Bone-marrow-derived macrophages (BMDMs)	0, 0.3, 1, 3, 10 μM	0.5 hours pretreatment followed by 0.5 hours LTA stimulation	To evaluate the effect of DHL on LTA-induced phosphorylation of p38 MAPK and NF-κB, results showed that DHL inhibited LTA-induced phosphorylation of p38 MAPK and NF-κB in a dose-dependent manner.	PMC8472345
RAW264.7 cells	0, 0.3, 1, 3, 10 μM	0.5 hours pretreatment followed by 0.5 hours LTA stimulation	To evaluate the effect of DHL on LTA-induced phosphorylation of p38 MAPK and NF-κB, results showed that DHL inhibited LTA-induced phosphorylation of p38 MAPK and NF-κB in a dose-dependent manner.	PMC8472345
RAW264.7 macrophages	1, 3, 9 μM	2 h pretreatment followed by LPS/IFNγ stimulation for 5 min to 24 h	To evaluate the anti-inflammatory effects of DCL. Results showed DCL significantly inhibited LPS/IFNγ-induced NO and PGE2 production, downregulated iNOS and COX-2 expression, and suppressed NF-κB signaling (reduced phosphorylation of IKKα/β and IκBα, prevented NF-κB p65 nuclear translocation). Additionally, DCL directly bound to IKKα/β and Keap1, inhibiting NF-κB while activating the Nrf2 pathway.	PMC8936814
AGS cells	0, 5, 10, 15, 20, 25 μM	24 and 48 hours	To evaluate the antiproliferative activity of Dehy, results showed that Dehy inhibited human GC cell proliferation in a dose- and time-dependent manner.	PMC11725148
MKN-28 cells	0, 5, 10, 15, 20, 25 μM	24 and 48 hours	To evaluate the antiproliferative activity of Dehy, results showed that Dehy inhibited human GC cell proliferation in a dose- and time-dependent manner.	PMC11725148
Primary mouse peritoneal macrophages (PMs)	1, 3, 9 μM	24 h	To validate anti-inflammatory effects in primary immune cells. DCL dose-dependently inhibited LPS/IFNγ-induced NO production.	PMC8936814
Bone-marrow-derived macrophages (BMDMs)	0, 0.3, 1, 3, 10 μM	24 hours	To evaluate the effect of DHL on the viability of BMDMs, results showed that DHL did not cause cytotoxicity at concentrations up to 10 μM.	PMC8472345
RAW264.7 cells	0, 0.3, 1, 3, 10 μM	24 hours	To evaluate the effect of DHL on the viability of RAW264.7 cells, results showed that DHL did not cause cytotoxicity at concentrations up to 10 μM.	PMC8472345
Rat nucleus pulposus cells	2.5 μM	24 hours	To evaluate the effects of dehydrocostus lactone on cytotoxicity and proliferation of nucleus pulposus cells. Results showed that 2.5 μM DHE slightly promoted cell proliferation, while concentrations ≥20 μM exhibited cytotoxicity.	PMC8079987
Huh7	8.311 µM (IC50)	24 hours	Evaluation of cytotoxic potential of dehydrocostus lactone on Huh7 cells with IC50 value of 8.311 µM	PMC9413334
Hep3B	4.97 µM (IC50)	24 hours	Evaluation of cytotoxic potential of dehydrocostus lactone on Hep3B cells with IC50 value of 4.97 µM	PMC9413334
HepG2	7.8 µM (IC50)	24 hours	Evaluation of cytotoxic potential of dehydrocostus lactone on HepG2 cells with IC50 value of 7.8 µM	PMC9413334
SW1353 human chondrocytes	10 and 20 μM	24 hours	DHC inhibited TNF-α-induced oxidative stress by suppressing the production of reactive oxygen species (ROS); decreased the expression of pro-inflammatory cytokines IL-1β and IL-6 induced by TNF-α; prevented the degradation of type II collagen and aggrecan by inhibiting the overexpression of MMP-1, MMP-3, MMP-13, ADAMTS-4, and ADAMTS-5; ameliorated the inflammatory response and degeneration of the articular extracellular matrix (ECM) by suppressing nuclear factor-κB (NF-κB) activation.	PMC7521500
Rat primary nucleus pulposus cells	2.5 μM	3 days	To evaluate the effects of dehydrocostus lactone on TNF-α-induced senescence of nucleus pulposus cells. Results showed that DHE treatment reversed TNF-α-induced senescence.	PMC8079987
RAW264.7 cells	0, 3, 5, 10, 30 μM	30 min pretreatment, 24 h LPS stimulation	Inhibited LPS-induced NO and iNOS production, reduced pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-12 expression	PMC6514677
Primary lung macrophages	0, 3, 5, 10, 30 μM	30 min pretreatment, 8 or 16 h LPS stimulation	Inhibited LPS-induced NO and iNOS production, reduced pro-inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-12 expression	PMC6514677
RAW264.7 cells	4 μM	4 hours pretreatment followed by RANKL stimulation for 0-60 minutes	To investigate the effect of DHE on RANKL-induced signaling pathways. Results showed that DHE suppressed RANKL-induced activation of NF-κB signaling pathway but had little effect on the phosphorylation of MAPK pathway.	PMC6653234
Bone marrow-derived macrophages (BMMs)	0, 0.5, 1, 2, 4 μM	5 days	To evaluate the effect of DHE on the differentiation of BMMs into osteoclasts. Results showed that DHE inhibited the formation of TRAP-positive multinucleated osteoclasts in a dose-dependent manner, with almost complete inhibition at 4 μmol/L concentration without affecting cell viability.	PMC6653234
HBE cells	0, 2, 4, 6, 8 and 10 μg/mL	6, 12, 24 hours	DHL showed low toxicity to HBE cells with IC50 > 25 μg/mL.	PMC7294112
TU212 cells	0, 2, 4, 6, 8 and 10 μg/mL	6, 12, 24 hours	DHL inhibited the proliferation of TU212 cells in a dose- and time-dependent manner and induced apoptosis.	PMC7294112
Hep-2 cells	0, 2, 4, 6, 8 and 10 μg/mL	6, 12, 24 hours	DHL inhibited the proliferation of Hep-2 cells in a dose- and time-dependent manner and induced apoptosis.	PMC7294112

Wistar rats	Benign prostatic hyperplasia model	Oral	0.075 mg/kg	Daily administration for 8 weeks	Dehydrocostus lactone significantly reduced prostate weight, prostate index, and prostate volume, and decreased epithelial cell thickness. Additionally, the BCL-2 mRNA expression level in the DCL group was significantly lower than that in the disease-induced group.	PMC7994664
BALB/c nude mice	Hep-2 nude mouse xenograft model	Intraperitoneal injection	10 and 15 mg/kg	Every 2 days for 3 weeks	DHL inhibited the growth of Hep-2 xenograft tumours and induced apoptosis in tumour cells without significant toxicity to the organs of nude mice.	PMC7294112
BALB/c nude mice	MKN-28 cell xenograft model	Intraperitoneal injection	15 and 30 mg/kg/day	Once daily for two weeks	To evaluate the anti-GC effect of Dehy in vivo, results showed that high-dose Dehy significantly inhibited the growth of MKN-28 xenografts.	PMC11725148
C57BL/6 mice	MRSA-induced acute lung injury model	Intraperitoneal injection	2.5 and 5 mg/kg	Single dose, lasted for 24 hours	To evaluate the effect of DHL on MRSA-induced acute lung injury, results showed that DHL significantly alleviated MRSA-induced lung injury, reducing inflammatory cell infiltration and alveolar structure destruction.	PMC8472345
C57BL/6 mice	Spinal instability model	Intraperitoneal injection	20 mg/kg	Once daily for 8 weeks	To evaluate the effects of dehydrocostus lactone on intervertebral disc degeneration. Results showed that DHE treatment partially ameliorated the loss of disc height and structural destruction.	PMC8079987
Rats	Oral administration model	Oral	300 mg/kg	Single dose, 24-hour sample collection	Study the metabolic network of Dehydrocostus Lactone in rats	PMC9696973
ICR mice	DSS-induced colitis model	Intragastric administration	5, 10, 15 mg/kg	Once daily for 8 days	To assess the therapeutic effects of DCL on DSS-induced colitis. Results demonstrated DCL significantly alleviated weight loss, colon shortening, increased spleen index, and colonic tissue damage (reduced CD68+ macrophage infiltration and MPO+ neutrophil accumulation), while restoring intestinal barrier function (upregulated ZO-1 and Occludin expression).	PMC8936814
C57BL/6 mice	LPS-induced acute lung injury model	Intraperitoneal injection	5, 10, 20 mg/kg	Single administration, evaluated after 24 h	Attenuated LPS-induced lung pathological injury, reduced inflammatory cell infiltration and pro-inflammatory cytokine expression, inhibited phosphorylation of p38 MAPK/MK2, Akt, and NF-κB	PMC6514677
Nude mice	EJ xenograft model	Oral gavage	50 mg/kg	Every other day for 20 days	To evaluate antitumor activity, results showed 81% tumor growth inhibition	PMC5995859
C57BL/6 mice	DSS-induced ulcerative colitis model	Oral administration	6, 12, 24 mg/kg/day	Once daily for 10 days	Dehydrocostus lactone alleviated DSS-induced weight loss, colon shortening, and pathological changes in mice by downregulating the expression of TLR4, PIK3R1, and RELA, thereby mitigating ulcerative colitis.	PMC11608259
C57BL/6 mice	LPS-induced bone loss model and titanium particle-induced calvarial osteolysis model	Intraperitoneal injection	7.5 μg/g and 15 μg/g	Started 1 day before LPS injection, administered every other day for up to 8 days	To evaluate the protective effect of DHE on LPS-induced bone loss and titanium particle-induced calvarial osteolysis. Results showed that DHE partially restored LPS-induced bone loss and titanium particle-induced calvarial osteolysis in a dose-dependent manner.	PMC6653234
BALB/c nude mice	DSS-induced colitis model	Tail vein injection	8 mg/mL, 100 μL	Single injection, observed for 72 hours	Evaluated the biodistribution of dehydrocostus lactone, showing higher accumulation in the lung and gastrointestinal tract	PMC7570101

{[proInfo.proName]}

CAS No.: 477-43-0

{[proInfo.proName]}

CAS No.: 477-43-0

Product Citations

Alternative Products

Product Details of Dehydrocostus Lactone

Safety of Dehydrocostus Lactone

Related Pathways of Dehydrocostus Lactone

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	4.34mL 0.87mL 0.43mL	21.71mL 4.34mL 2.17mL	43.42mL 8.68mL 4.34mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed