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Chemical Structure| 989-51-5 Chemical Structure| 989-51-5
Chemical Structure| 989-51-5

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(-)-Epigallocatechin Gallate is a major polyphenol in green tea that inhibits cell proliferation, induces apoptosis, inhibits glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) activity, and has anticancer, antioxidant, and anti-inflammatory properties.

Synonyms: EGCG; Epigallocatechol Gallate; EGCG-Epigallocatechin Gallate)

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Product Citations

Product Citations

Krueger, Nadine ; Kronenberger, Thales ; Xie, Hang ; Rocha, Cheila ; Poehlmann, Stefan ; Su, Haixia , et al.

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has forced the development of direct-acting antiviral drugs due to the coronavirus disease 2019 (COVID-19) pandemic. The main protease of SARS-CoV-2 is a crucial enzyme that breaks down polyproteins synthesized from the viral RNA, making it a validated target for the development of SARS-CoV-2 therapeutics. New chem. phenotypes are frequently discovered in natural goods. In the current study, we used a fluorogenic assay to test a variety of natural products for their ability to inhibit SARS-CoV-2 Mpro. Several compounds were discovered to inhibit Mpro at low micromolar concentrations It was possible to crystallize robinetin together with SARS-CoV-2 Mpro, and the X-ray structure revealed covalent interaction with the protease's catalytic Cys145 site. Selected potent mols. also exhibited antiviral properties without cytotoxicity. Some of these powerful inhibitors might be utilized as lead compounds for future COVID-19 research.

Keywords: COVID-19 ; antivirals ; coronavirus ; covalent drugs ; dynamic light scattering ; inhibitors ; main protease ; natural products

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Product Details of (-)-Epigallocatechin Gallate

CAS No. :989-51-5
Formula : C22H18O11
M.W : 458.37
SMILES Code : O=C(O[C@H]1[C@@H](C2=CC(O)=C(O)C(O)=C2)OC3=C(C(O)=CC(O)=C3)C1)C4=CC(O)=C(O)C(O)=C4
Synonyms :
EGCG; Epigallocatechol Gallate; EGCG-Epigallocatechin Gallate)
MDL No. :MFCD00075940
InChI Key :WMBWREPUVVBILR-WIYYLYMNSA-N
Pubchem ID :65064

Safety of (-)-Epigallocatechin Gallate

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338
 

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