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[ CAS No. 100063-22-7 ]

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Chemical Structure| 100063-22-7
Chemical Structure| 100063-22-7
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Product Details of [ 100063-22-7 ]

CAS No. :100063-22-7 MDL No. :MFCD00068161
Formula : C12H11NO2S Boiling Point : 442.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :233.29 g/mol Pubchem ID :-
Synonyms :

Safety of [ 100063-22-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 100063-22-7 ]

  • Downstream synthetic route of [ 100063-22-7 ]

[ 100063-22-7 ] Synthesis Path-Downstream   1~17

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  • [ 1943-83-5 ]
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  • [ 126080-13-5 ]
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  • [ 100063-22-7 ]
  • [ 113387-58-9 ]
YieldReaction ConditionsOperation in experiment
Reference Example 1; Methyl 3-chlorosulfonyl-5-phenyl-2-thiophenecarboxylate; Methyl 3-amino-5-phenyl-2-thiophenecarboxylate (5 g, manufactured by AK Scientific, Inc.) was dissolved in 20% hydrochloric acid (12 ml), and sodium nitrite (1.5 g, manufactured by Wako Pure Chemical Industries, Ltd.) dissolved in water (3.2 ml) under ice cooling was dripped to the resultant solution, and the resultant reaction solution was stirred for 1 hour. An acetic acid solution in which sulfur dioxide (2.5 g) and copper chloride (530 mg, manufactured by KANTO CHEMICAL CO., INC.) were dissolved was slowly added to the solution, and the resultant reaction solution was stirred for 5 hours. The reaction mixture was poured into ice water (100 ml), and a product was extracted with dichloromethane (100 ml), dried with magnesium sulfate and then concentrated to give 6.5 g of the titled compound.
  • 3
  • [ 100063-22-7 ]
  • [ 26118-67-2 ]
  • [ 123420-33-7 ]
  • 4
  • [ 124-42-5 ]
  • [ 100063-22-7 ]
  • [ 156424-47-4 ]
  • 5
  • [ 100063-22-7 ]
  • [ 4755-77-5 ]
  • 3-(ethoxyoxalyl-amino)-5-phenyl-thiophene-2-carboxylic acid methyl ester [ No CAS ]
  • 6
  • [ 100063-22-7 ]
  • 3-chloro-5-phenylthiophene-2-carboxylic acid [ No CAS ]
  • 7
  • [ 75-30-9 ]
  • [ 100063-22-7 ]
  • [ 478028-16-9 ]
  • 8
  • [ 75-44-5 ]
  • [ 100063-22-7 ]
  • [ 478028-43-2 ]
YieldReaction ConditionsOperation in experiment
65% With potassium hydroxide; In water; toluene; Example 119A 6-phenyl-2H-thieno[3,2-d][1,3]oxazine-2,4(1H)-dione Methyl-3-amino-5-phenylthiophene-2-carboxylate (0.25 g, 1.07 mmol) in water (6 mL) was reacted with potassium hydroxide (0.12 g, 2.14 mmol) at 90 C. for 24 hours. The reaction was cooled to 0 C. and phosgene (1.9M in toluene, 0.70 mL, 1.40 mmol) was added dropwise. After stirring at room temperature for 1 hour, the resulting solid was collected by filtration, washed with excess water and dried to give the title compound as a tan solid (0.175 g, 65%).
65% methyl-3-amino-5-phenylthiophene-2-carboxylate (0.25 g, 1.07 mmol) in water (6 ML) was reacted with potassium hydroxide (0.12 g, 2.14 mmol) at 90 C. for 24 hours.The reaction was cooled to 0 C. and phosgene (1.9M in toluene, 0.70 ML, 1.40 mmol) was added dropwise.After stirring at room temperature for 1 hour, the resulting solid was collected by filtration, washed with excess water and dried to give the title compound as a tan solid (0.175 g, 65%).
65% 6-phenyl-2H-thieno [3,2-d][1,3]oxazine-2,4(1H)-dione methyl-3-amino-5-phenylthiophene-2-carboxylate (0.25 g, 1.07 mmol) in water (6 ML) was reacted with potassium hydroxide (0.12 g, 2.14 mmol) at 90 C. for 24 hours.The reaction was cooled to 0 C. and phosgene (1.9M in toluene, 0.70 ML, 1.40 mmol) was added dropwise.After stirring at room temperature for 1 hour, the resulting solid was collected by filtration, washed with excess water and dried to give the title compound as a tan solid (0.175 g, 65%).
  • 9
  • [ 88-49-3 ]
  • [ 100063-22-7 ]
  • 3-(4-chloro-2,5-dimethyl-benzenesulfonylamino)-5-phenyl-thiophene-2-carboxylic acid methyl ester [ No CAS ]
  • 10
  • [ 874-60-2 ]
  • [ 100063-22-7 ]
  • [ 477326-18-4 ]
  • 11
  • [ 100063-22-7 ]
  • [ 99972-47-1 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In methanol; water; for 3h;Reflux; General procedure: The 5-aryl-3-amino-2-carboxylic acid methyl ester (16.6 mmol) was added to a solution of KOH (60 mL, 0.6 M inH2O) and MeOH (60 mL). The mixture was heated to reflux for 3 h,concentrated, and washed with EtOAc (2 50 mL). The aqueous layer was cooled with ice and acidified by addition of a saturated aqueous solution of KHSO4. The precipitated solid was collected by filtration, washed with H2O (2 30 mL) and dried under reduced pressure over CaCl2.
With potassium hydroxide; In tetrahydrofuran; methanol; water; for 3h;Reflux; General procedure: The 5-Aryl-3-amino-2-carboxylic acid methyl ester (16.6 mmol) was added to a solution of KOH (60 mL, 0.6 M in H2O) and MeOH (60 mL). The mixture was heated to reflux for 3 h, concentrated, and washed with EtOAc (2 x 50 mL). The aqueous layer was cooled with ice and acidified with a saturated aqueous solution of KHSO4.The precipitated solid was collected by filtration, washed with H2O (2 x 30 mL) and dried under reduced pressure over CaCl2.
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  • [ 100063-22-7 ]
  • [ 74-88-4 ]
  • [ 478028-07-8 ]
  • 14
  • [ 116-11-0 ]
  • [ 100063-22-7 ]
  • [ 478028-16-9 ]
YieldReaction ConditionsOperation in experiment
96% With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; for 2h; To a stirred solution of 3-Amino-5-phenyl-thiophene-2- carboxylic acid methyl ester (1.82 g, 7.8 mmol) in 1, 2- dichloroethane (40 mL) was added sequentially 2- methoxypropene (3.0 mL, 31.2 mmol), ACOH (1.8 mL, 31.2 mmol) and NaBH (OAc) 3 (3.31 g, 15.6 mmol) and stirred for 2 hrs. It was then diluted with EtOAc and H 20. The aqueous solution was adjusted to pH = 7 by adding NAHCO3. The aqueous phase was extracted with EtOAc, the combined extract was washed with brine and dried on MGS04 and filtered. Purification on bond elute with hexane to 5% EtOAc-hexane furnished 3-Isopropylamino-5- phenyl-thiophene-2-carboxylic acid methyl ester (2.07 g, 96% yield NMR (CDC1 3, 400 MHz): 8 7.62 (d, 2H), 7.40 (m, 3H) 6.91 (s, 1H), 3.84 (s, 3H), 3.71 (m, 1H), 1. 35 (d, 6H).
To a solution of S-amino-δ-phenyl-thiophene^-carboxylic acid methyl ester (4.92 g, 21.1 mmol) in DCM (1 10 mL) was added 2-methoxypropene (8.23 mL, 84.4 mmol), acetic acid (4.83 mL, 84.4 mmol) and sodium triacetoxyborohydride (8.94 g, 42.2 mmol) and the mixture <n="38"/>stirred overnight. Ethyl acetate and water were added, the aqueous phase adjusted to pH7 using sodium bicarbonate and then extracted with ethyl acetate. The combined organic extracts were washed with brine and dried over sodium sulphate. The crude product was purified by silica chromatography using a Flashmaster Personal apparatus (Argonaut) eluting with DCM / cyclohexane (1 :4) to give the title compound. MS calcd for (C15H17NO2S+ H)+: 276 MS found (electrospray): (M+H)+ =276
To a solution of S-amino-δ-phenyl-thiophene^-carboxylic acid methyl ester (4.92 g, 21.1 mmol) in DCM (1 10 ml.) was added 2-methoxypropene (8.23 ml_, 84.4 mmol), acetic acid (4.83 ml_, 84.4 mmol) and sodium triacetoxyborohydride (8.94 g, 42.2 mmol) and the mixture stirred overnight. Ethyl acetate and water were added, the aqueous phase adjusted to pH7 using sodium bicarbonate and then extracted with ethyl acetate. The combined organic extracts were washed with brine and dried over sodium sulphate. The crude product was purified by silica chromatography using a Flashmaster Personal apparatus (Argonaut) eluting with DCM / cyclohexane (1 :4) to give the title compound. MS calcd for (Ci5H17NO2S+ H)+: 276 MS found (electrospray): (M+H)+ =276
Intermediate 30 Methyl 3-[(1 -methylethyljaminol-δ-phenyl^-thiophenecarboxylateTo a solution of S-amino-δ-phenyl-thiophene^-carboxylic acid methyl ester (4.92 g, 21.1 mmol) in DCM (1 10 ml.) was added 2-methoxypropene (8.23 ml_, 84.4 mmol), acetic acid (4.83 ml_, 84.4 mmol) and sodium triacetoxyborohydride (8.94 g, 42.2 mmol) and the mixture stirred overnight. Ethyl acetate and water were added, the aqueous phase adjusted to pH7 using sodium bicarbonate and then extracted with ethyl acetate. The combined organic extracts were washed with brine and dried over sodium sulphate. The crude product was <n="46"/>purified by silica chromatography using a Flashmaster Personal apparatus (Argonaut) eluting with DCM / cyclohexane (1 :4) to give the title compound. MS calcd for (C15H17NO2S+ H)+: 276 MS found (electrospray): (M+H)+ =276

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  • [ 100063-22-7 ]
  • [ 1000409-69-7 ]
YieldReaction ConditionsOperation in experiment
With phenyltrimethylammonium tribromide; calcium carbonate; In methanol; dichloromethane; EXAMPLE 8A methyl 3-amino-4-bromo-5-phenylthiophene-2-carboxylate To a mixture of <strong>[100063-22-7]methyl 3-amino-5-phenylthiophene-2-carboxylate</strong> (2.33 g, 10 mmol) and phenyltrimethylammonium tribromide (9.4 g, 25 mmol) in dichloromethane (25 mL) and methanol (25 mL) was added calcium carbonate (4.03 g, 40 mmol) and the mixture stirred overnight. The solid was filtered off and the filtrate concentrated. The residue was purified by flash chromatography on silica gel using 1:10 ethyl acetate/hexanes to give 2.75 g of the title compound. 1H NMR (DMSO-d6) δ 7.62-7.65 (m, 2H), 7.47-7.51 (m, 3H), 3.80 (s, 3H).
With phenyltrimethylammonium tribromide; calcium carbonate; In methanol; dichloromethane; EXAMPLE 8A methyl 3-amino-4-bromo-5-phenylthiophene-2-carboxylate To a mixture of <strong>[100063-22-7]methyl 3-amino-5-phenylthiophene-2-carboxylate</strong> (2.33 g, 10 mmol) and phenyltrimethylammonium tribromide (9.4 g, 25 mmol) in dichloromethane (25 mL) and methanol (25 mL) was added calcium carbonate (4.03 g, 40 mmol) and the mixture stirred overnight. The solid was filtered off and the filtrate concentrated. The residue was purified by flash chromatography on silica gel using 1:10 ethyl acetate/hexanes to give 2.75 g of the title compound. 1H NMR (DMSO-d6) δ 7.62-7.65 (m, 2H), 7.47-7.51 (m, 3H), 3.80 (s, 3H).
With bromine; acetic acid; at 60℃; for 0.75h; Step 8A: To a solution of methyl-3-amino-5-phenyl thiophene-2-carboxylate (1.0 g, 4.10 mmol) in HOAc (15.0 mL) was added Br2 (0.63 mL, 12.3 mmol). The reaction was heated to 60 C. and allowed to stir approximately 45 minutes, after which it was judged complete by LCMS. The excess Br2 was quenched with excess Na2S2O3, and the crude product was extracted (3*25 mL) into DCM. The combined organic layers were dried over MgSO4 and concentrated in vacuo, affording 1.6 g of crude methyl 3-amino-4-bromo-5-phenylthiophene-2-carboxylate as a light yellow solid >90% purity. 1H NMR (400 MHz, CHLOROFORM-D) δ ppm 3.87 (s, 3 H) 5.74 (br. s, 2 H) 7.41-7.49 (m, 3 H) 7.63-7.68 (m, 2 H); LCMS: m/e=282.1 [M+H]+
  • 16
  • [ 5878-19-3 ]
  • [ 100063-22-7 ]
  • [ 1007171-29-0 ]
YieldReaction ConditionsOperation in experiment
To a solution of methyl S-amino-δ-phenyl^-thiophenecarboxylate (2.0 g; 8.58 mmol) and acetic acid (5 ml.) in dry dichloromethane (100 ml.) was added methoxyacetone (0.91 g; 10.3 mmol) and the reaction mixture stirred at room temperature under nitrogen for 10 minutes. Sodium triacetoxyborohydride (3.6 g; 17.2 mmol) was added in 3 portions and the reaction mixture warmed to reflux under nitrogen for 3 days. A further equivalent sodium triacetoxyborohydride (1.8 g; 8.6 mmol) was added and the reaction mixture stirred to reflux under nitrogen for 2 days. Sodium bicarbonate solution (100 ml.) was added and the mixture stirred for 30 minutes, passed through a hydrophobic frit and evaporated to dryness. The crude product was purified by 120 g silica ISCO chromatography eluted with 0 - 100%EtOAc in cyclohexane to give the title compound.MS calcd for (Ci6H19NO3S + H)+: 306MS found (electrospray): (M+H)+ = 306
Intermediate 31Methyl 3-[1 -methyl-2-(methyloxy)ethyl]amino}-5-phenyl-2-thiophenecarboxylateTo a solution of methyl S-amino-δ-phenyl^-thiophenecarboxylate (2.0 g; 8.58 mmol) and glacial acetic acid (5 ml.) in dry dichloromethane (100 ml.) was added methoxyacetone (0.91 g, 10.3 mmol) and the reaction stirred at room temperature under nitrogen for 10 minutes. Sodium triacetoxyborohydride (3.6 g, 17.2 mmol) was added and the reaction heated at reflux under nitrogen for 3 days. A further addition of sodium triacetoxyborohydride (1.8 g, 8.6 mmol) was added and the reaction heated at reflux under nitrogen for 2 days. After <n="44"/>cooling to room temperature sodium bicarbonate solution (100 ml.) was added and the reaction stirred for 30 minutes, dried using a hydrophobic frit and evaporated to dryness. The crude product was purified by 120 g Si ISCO chromatography eluted EtOAc in cyclohexane (gradient from 0-100%) to give title compound. MS calcd for (Ci6H19NO3S + H)+: 306 MS found (electrospray): (M+H)+ = 306
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  • [ 2365-48-2 ]
  • [ 33513-42-7 ]
  • [ 98-86-2 ]
  • [ 100063-22-7 ]
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