Alternatived Products of [ 99972-47-1 ]
Product Details of [ 99972-47-1 ]
CAS No. : | 99972-47-1 |
MDL No. : | MFCD09756507 |
Formula : |
C11H9NO2S
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
219.26
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 99972-47-1 ]
Signal Word: | |
Class: | |
Precautionary Statements: | |
UN#: | |
Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 99972-47-1 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 99972-47-1 ]
- 1
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[ 609-60-9 ]
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[ 99972-47-1 ]
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3-(2,4-dimethyl-benzenesulfonylamino)-5-phenyl-thiophene-2-carboxylic acid
[ No CAS ]
- 2
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[ 56157-92-7 ]
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[ 99972-47-1 ]
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3-(4-chloro-2-methyl-benzenesulfonylamino)-5-phenyl-thiophene-2-carboxylic acid
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium carbonate In 1,4-dioxane |
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Reference:
[1]Chan, Laval; Das, Sanjoy K.; Reddy, T. Jagadeeswar; Poisson, Carl; Proulx, Melanie; Pereira, Oswy; Courchesne, Marc; Roy, Caroline; Wang, Wuyi; Siddiqui, Arshad; Yannopoulos, Constantin G.; Nguyen-Ba, Nghe; Labrecque, Denis; Bethell, Richard; Hamel, Martine; Courtemanche-Asselin, Philippe; L'Heureux, Lucille; David, Maud; Nicolas, Olivier; Brunette, Stephanie; Bilimoria, Darius; Bedard, Jean
[Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 3, p. 793 - 796]
- 3
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[ 100063-22-7 ]
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[ 99972-47-1 ]
Yield | Reaction Conditions | Operation in experiment |
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With potassium hydroxide; In methanol; water; for 3h;Reflux; |
General procedure: The 5-aryl-3-amino-2-carboxylic acid methyl ester (16.6 mmol) was added to a solution of KOH (60 mL, 0.6 M inH2O) and MeOH (60 mL). The mixture was heated to reflux for 3 h,concentrated, and washed with EtOAc (2 50 mL). The aqueous layer was cooled with ice and acidified by addition of a saturated aqueous solution of KHSO4. The precipitated solid was collected by filtration, washed with H2O (2 30 mL) and dried under reduced pressure over CaCl2. |
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With potassium hydroxide; In tetrahydrofuran; methanol; water; for 3h;Reflux; |
General procedure: The 5-Aryl-3-amino-2-carboxylic acid methyl ester (16.6 mmol) was added to a solution of KOH (60 mL, 0.6 M in H2O) and MeOH (60 mL). The mixture was heated to reflux for 3 h, concentrated, and washed with EtOAc (2 x 50 mL). The aqueous layer was cooled with ice and acidified with a saturated aqueous solution of KHSO4.The precipitated solid was collected by filtration, washed with H2O (2 x 30 mL) and dried under reduced pressure over CaCl2. |
Reference:
[1]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 797 - 800
[2]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 2817 - 2822
[3]Bioorganic and Medicinal Chemistry Letters,2004,vol. 14,p. 5333 - 5337
[4]European Journal of Medicinal Chemistry,2013,vol. 65,p. 223 - 231
[5]European Journal of Medicinal Chemistry,2015,vol. 96,p. 14 - 21
- 4
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[ 174485-72-4 ]
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[ 99972-47-1 ]
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5-phenyl-3-(5-trifluoromethyl-pyridine-2-sulfonylamino)-thiophene-2-carboxylic acid
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With sodium carbonate In 1,4-dioxane |
|
Reference:
[1]Yannopoulos, Constantin G.; Xu, Ping; Ni, Feng; Chan, Laval; Pereira, Oswy Z.; Reddy, T. Jagadeeswar; Das, Sanjoy K.; Poisson, Carl; Nguyen-Ba, Nghe; Turcotte, Nathalie; Proulx, Melanie; Halab, Lilianne; Wang, Wuyi; Bédard, Jean; Morin, Nicolas; Hamel, Martine; Nicolas, Olivier; Bilimoria, Darius; L'Heureux, Lucille; Bethell, Richard; Dionne, Gervais
[Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 21, p. 5333 - 5337]
- 5
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[ 99972-47-1 ]
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[ 122375-70-6 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 2 steps
1: SOCl2
2: NH3 / acetonitrile |
|
Reference:
[1]Baxter, Andrew; Brough, Steve; Cooper, Anne; Floettmann, Eike; Foster, Steve; Harding, Christine; Kettle, Jason; McInally, Tom; Martin, Craig; Mobbs, Michelle; Needham, Maurice; Newham, Pete; Paine, Stuart; St-Gallay, Steve; Salter, Sylvia; Unitt, John; Xue, Yafeng
[Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 11, p. 2817 - 2822]
- 6
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[ 78583-84-3 ]
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[ 99972-47-1 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 2 steps
1: natrium; methanol / 0.5 h / Reflux
2: potassium hydroxide / methanol; lithium hydroxide monohydrate / 3 h / Reflux |
|
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Multi-step reaction with 2 steps
1: natrium / methanol / 0.5 h / Reflux
2: potassium hydroxide / methanol; lithium hydroxide monohydrate; tetrahydrofuran / 3 h / Reflux |
|
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Multi-step reaction with 2 steps
1: sodium methoxide / methanol / 0.5 h / Reflux
2: potassium hydroxide / methanol; lithium hydroxide monohydrate / 3 h / Reflux |
|
Reference:
[1]Sahner, J. Henning; Groh, Matthias; Negri, Matthias; Haupenthal, Jörg; Hartmann, Rolf W.
[European Journal of Medicinal Chemistry, 2013, vol. 65, p. 223 - 231]
[2]Sahner, J. Henning; Empting, Martin; Kamal, Ahmed; Weidel, Elisabeth; Groh, Matthias; Börger, Carsten; Hartmann, Rolf W.
[European Journal of Medicinal Chemistry, 2015, vol. 96, p. 14 - 21]
[3]Kiefer, Alexander F.; Bousis, Spyridon; Hamed, Mostafa M.; Diamanti, Eleonora; Haupenthal, Jörg; Hirsch, Anna K.H.
[Journal of Medicinal Chemistry, 2021]