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Chemical Structure| 100390-87-2 Chemical Structure| 100390-87-2

Structure of 100390-87-2

Chemical Structure| 100390-87-2

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Product Details of [ 100390-87-2 ]

CAS No. :100390-87-2
Formula : C12H15NO3
M.W : 221.25
SMILES Code : O=C(OCC1=CC=CC=C1)NC2COCC2

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Application In Synthesis of [ 100390-87-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 100390-87-2 ]

[ 100390-87-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 100390-87-2 ]
  • [ 88675-24-5 ]
YieldReaction ConditionsOperation in experiment
With hydrogen;palladium 10% on activated carbon; In methanol; hydrogen chloride; water; at 20℃; under 760.051 Torr; for 18h; [0152] 2) The N-benzyloxycarbonyl-3-aminotetrahydrofuran thus prepared (3.4 gm, 15 mmol) was dissolved in methanol (50 ml) and concentrated hydrochloric acid. Pd-C (10percent, 300 mg) was added, and the mixture was hydrogenated at 1 atmosphere for 18 hours at room temperature. The mixture was filtered through a pad of celite, and the filtrate concentrated under reduced pressure. The residue was co-evaporated twice with a mixture of ethyl acetate and methanol, and then recrystallized from a mixture of ethyl acetate and methanol to give 1.9 g of 3-aminotetrahydrofuran as a yellow solid.[0153] If the starting 3-tetrahydrofuroic acid is chiral, then the product (3-aminotetrahydrofuran) is also chiral, i.e., the synthesis is stereospecific.
 

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