Name: 1005500-75-3|N-Ethynyl-N,4-dimethylbenzenesulfonamide|98%
Brand: Ambeed
SKU: A800670
Price: 8.0 USD
Availability: InStock
Rating: 95 (32 reviews)

1
[ 1885-38-7 ]
[ 1005500-75-3 ]
(E)-N,N'-(6-styrylpyridine-2,4-diyl)bis(N,4-dimethylbenzenesulfonamide) [ No CAS ]

Reference： [1]Chemical Communications,2016,vol. 52,p. 3187 - 3190

2
[ 1005500-75-3 ]
[ 65-85-0 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In dichloromethane at 20℃; for 12h; Inert atmosphere; Schlenk technique;
99%	In dichloromethane at 25℃; for 1.5h;
99%	In dichloromethane at 20℃; for 1.5h;	16 Example 16 In a clean 25 mL reaction tubeN-methyl-N-ethynyl-p-toluenesulfonamide (0.20 mmol) was added,Benzoic acid (0.2 mmol),Adding appropriate amount of dichloromethane as solvent,At room temperature for 1.5 hours,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 99%.

99%	In dichloromethane at 20℃;
	With silver(l) oxide In 1,4-dioxane at 100℃; for 5h; Inert atmosphere; Schlenk technique;
	In dichloromethane at 20℃; for 2h;

Reference： [1]Cui, Sunliang; He, Jixiao; Jin, Jian; Zeng, Linwei [Chemical Communications, 2021, vol. 57, # 55, p. 6792 - 6795]
[2]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]
[3]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0015; 0016
[4]Wang, Xuewei; Zhao, Yongli; Yang, Jinhua; Li, Yanxi; Luo, Ying; Xu, Mengyao; Zhao, Junfeng [Journal of Organic Chemistry, 2021, vol. 86, # 24, p. 18265 - 18277]
[5]Zeng, Linwei; Huang, Bo; Shen, Yangyong; Cui, Sunliang [Organic Letters, 2018, vol. 20, # 12, p. 3460 - 3464]
[6]Cao, Weidi; Feng, Xiaoming; Jiang, Mingyi; Li, Xiangqiang; Zhan, Tangyu [Chemistry - An Asian Journal, 2020]

3
[ 64-18-6 ]
[ 1005500-75-3 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl formate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 25℃; for 0.166667h;
99%	In dichloromethane at 10℃; for 0.166667h;	1 Example 1 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (0.20 mmol) was added,Formic acid (2 mmol),Adding appropriate amount of dichloromethane as solvent,At 10 degrees Celsius,Reaction for 10 minutes,TLC spot plate detection,After completion of the reaction the solvent was concentrated and subjected to column chromatography to give the pure product as a white solid,Yield 99%.

Reference： [1]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]
[2]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Page/Page column 8; 9

4
[ 1005500-75-3 ]
[ 828-51-3 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl adamantane-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 0℃; for 4h;	2 Example 2 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (0.20 mmol) was added, 1-adamantanecarboxylic acid (0.3 mmol),Adding appropriate amount of dichloromethane as solvent,At 0 degrees Celsius reaction 4 hours,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 99%.
98%	In dichloromethane at 25℃; for 3h;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0001; 0002
[2]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]

5
[ 1005500-75-3 ]
[ 74-11-3 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl 4-chlorobenzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 20℃; for 6h;	3 Example 3 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (0.30 mmol) was added, p-chlorobenzoic acid (0.2 mmol),Adding appropriate amount of dichloromethane as solvent,At room temperature for 6 hours,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 99%.
99%	In dichloromethane at 20℃;
98%	In dichloromethane at 25℃; for 4h;

In 5,5-dimethyl-1,3-cyclohexadiene at 80℃; for 1h; Schlenk technique; Inert atmosphere;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0002; 0003
[2]Wang, Xuewei; Zhao, Yongli; Yang, Jinhua; Li, Yanxi; Luo, Ying; Xu, Mengyao; Zhao, Junfeng [Journal of Organic Chemistry, 2021, vol. 86, # 24, p. 18265 - 18277]
[3]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]
[4]Shen, Yangyong; Li, Qi; Xu, Gang; Cui, Sunliang [Organic Letters, 2018, vol. 20, # 17, p. 5194 - 5197]

6
[ 88-14-2 ]
[ 1005500-75-3 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl furan-2-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 20℃;
98%	In dichloromethane at 25℃; for 0.5h;
98%	In dichloromethane at 20℃; for 0.5h;	4 Example 4 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide(0.20 mmol) was added, 2-furoic acid (0.2 mmol),Adding appropriate amount of dichloromethane as solvent,At room temperature for 30 minutes,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 98%.

Reference： [1]Wang, Xuewei; Zhao, Yongli; Yang, Jinhua; Li, Yanxi; Luo, Ying; Xu, Mengyao; Zhao, Junfeng [Journal of Organic Chemistry, 2021, vol. 86, # 24, p. 18265 - 18277]
[2]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]
[3]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0003; 0004

7
[ 50890-83-0 ]
[ 1005500-75-3 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl 1-methyl-1H-indazole-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In chloroform; at 20℃; for 5h;	In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (2.0 mmol) was added, <strong>[50890-83-0]1-methylindazole-3-carboxylic acid</strong> (0.2 mmol)Add appropriate amount of chloroform as solvent,At room temperature for 5 hours,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 99%.

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 13135 - 13138
[2]Patent: CN106146359,2016,A .Location in patent: Paragraph 0004; 0005

8
[ 5381-25-9 ]
[ 1005500-75-3 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl benzo[b]thiophene-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	In dichloromethane; at 40℃; for 1h;	In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (1.0 mmol) was added, <strong>[5381-25-9]1-<strong>[5381-25-9]benzothiophene-3-carboxylic acid</strong></strong> (0.2 mmol)Adding appropriate amount of dichloromethane as solvent,At 40 degrees Celsius for 1 hour,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 100%.

Reference： [1]Patent: CN106146359,2016,A .Location in patent: Paragraph 0005; 0006
[2]Journal of the American Chemical Society,2016,vol. 138,p. 13135 - 13138

9
[ 1005500-75-3 ]
[ 637-44-5 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl 3-phenylpropiolate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 25℃; for 0.133333h;
99%	In dichloromethane at 0℃; for 0.166667h;	8 Example 8 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (0.80 mmol) was added, phenylpropiolic acid (0.2 mmol),Adding appropriate amount of dichloromethane as solvent,Reaction at 0 ° C for 10 minutes,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 99%.

Reference： [1]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]
[2]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0007; 0008

10
[ 1005500-75-3 ]
[ 102410-65-1 ]
C₃₃H₃₀N₂O₆S [ No CAS ]

Reference： [1]Journal of the American Chemical Society,2016,vol. 138,p. 13135 - 13138

11
[ 1005500-75-3 ]
[ 1145-80-8 ]
1-((N,4-dimethylphenyl)sulfonamido)vinyl ((benzyloxy)carbonyl)-L-serinate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 25℃; for 0.583333h;
99%	In dichloromethane at 30℃; for 0.5h;	9 Example 9 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (0.20 mmol) was added, N-benzyloxycarbonyl-L-serine (0.2 mmol)Adding appropriate amount of dichloromethane as solvent,At 30 degrees Celsius for 30 minutes,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,solid,Yield 99%.

Reference： [1]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]
[2]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0008; 0009

12
[ 1005500-75-3 ]
[ 7432-21-5 ]
N-benzyloxycarbonyl-L-tryptophan 1-(N-methyl-p-toluenesulfonamido)ethenyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	In dichloromethane at 20℃; for 0.5h;	11 Example 11 In a clean 25 mL reaction tube N-methyl-N-ethynyl-p-toluenesulfonamide (0.20 mmol) was added, N-benzyloxycarbonyl-L-tryptophan (0.24 mmol)Adding appropriate amount of dichloromethane as solvent,At room temperature for 30 minutes,TLC spot plate detection,After completion of the reaction, the solvent was concentrated and subjected to column chromatography to give pure product,White solid,Yield 99%.
99%	In dichloromethane at 20℃;
	In dichloromethane at 35℃;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN106146359, 2016, A Location in patent: Paragraph 0010; 0011
[2]Wang, Xuewei; Zhao, Yongli; Yang, Jinhua; Li, Yanxi; Luo, Ying; Xu, Mengyao; Zhao, Junfeng [Journal of Organic Chemistry, 2021, vol. 86, # 24, p. 18265 - 18277]
[3]Hu, Long; Xu, Silin; Zhao, Zhenguang; Yang, Yang; Peng, Zhiyuan; Yang, Ming; Wang, Changliu; Zhao, Junfeng [Journal of the American Chemical Society, 2016, vol. 138, # 40, p. 13135 - 13138]

13
[ 1005500-75-3 ]
[ 81-23-2 ]
[ 100-52-7 ]
[ 62-53-3 ]
(4R)-4-((8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7,12-trioxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N-((R)-3-((N,4-dimethylphenyl)sulfonamido)-3-oxo-1-phenylpropyl)-N-phenylpentanamide [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 4565 - 4568
Angew. Chem.,2017,vol. 56,p. 4565 - 4568,4

14
[ 57476-50-3 ]
[ 1005500-75-3 ]
[ 62-53-3 ]
[ 65-85-0 ]
tert-butyl-3-(3-((N,4-dimethylphenyl)sulfonamido)-3-oxo-1-(N-phenylbenzamido)propyl)-1H-indole-1-carboxylate [ No CAS ]

Reference： [1]Angewandte Chemie - International Edition,2017,vol. 56,p. 4565 - 4568
Angew. Chem.,2017,vol. 56,p. 4565 - 4568,4

15
[ 57476-50-3 ]
[ 1005500-75-3 ]
[ 62-23-7 ]
3-(3-((N,4-dimethylphenyl)sulfonamido)-1-((4-nitrobenzoyl)oxy)-3-oxopropyl)-1H-indole-1-carboxylate [ No CAS ]

Reference： [1]Organic Letters,2017,vol. 19,p. 4616 - 4619

16
[ 75-35-4 ]
[ 640-61-9 ]
[ 1005500-75-3 ]

Yield	Reaction Conditions	Operation in experiment
93%	With sodium hydroxide; In N,N-dimethyl-formamide; at 70℃; for 24h;Schlenk technique;	Add 0.2 mmol of N-methyl-p-toluenesulfonamide and a stirrer to a clean Schlenk reaction tube.Then, 1.0 mL of DMF solvent was added by syringe, and 1.0 mmol of NaOH was added to the reaction tube.Finally, 0.6 mmol of 1,1-dichloroethylene was added with a micro syringe, and the bottle was stoppered with a soft rubber stopper, and reacted at 70 C for 24 hours.TLC dot plate detection; after the reaction is completed, the reaction solution is added with ice water and extracted with ethyl acetate three times.The organic layer is concentrated and separated by column chromatography to obtain pure N-methyl-N-ethynyl p-toluenesulfonamide.White solid, yield 93%.

Reference： [1]Organic Letters,2018,vol. 20,p. 280 - 283
[2]Patent: CN109320441,2019,A .Location in patent: Paragraph 0017-0019
[3]Angewandte Chemie - International Edition,2019,vol. 58,p. 1382 - 1386
Angew. Chem.,2019,vol. 131,p. 1396 - 1400,5
[4]Organic Letters,2018,vol. 20,p. 5688 - 5691
[5]Advanced synthesis and catalysis,2019

17
[ 1005500-75-3 ]
[ 640-61-9 ]
(Z)-N,N′-(ethene-1,2-diyl)bis(N,4-dimethylbenzenesulfonamide) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique;	1 Example 1 Add 0.1 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.2 mmol), N-methyl-p-toluenesulfonamide (0.4 mmol) and a stirrer, then add 1 mL of dimethyl sulfoxide, and finally stopper the bottle with a soft rubber stopper, and react at room temperature for 24 hours, TLC dot plate After the reaction is completed, after the reaction is completed, the pure product is obtained by column chromatography to give a white solid, yield 99%.
99%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Page/Page column 7
[2]Peng, Zhiyuan; Zhang, Zhenming; Tu, Yongliang; Zeng, Xianzhu; Zhao, Junfeng [Organic Letters, 2018, vol. 20, # 18, p. 5688 - 5691]

18
[ 1005500-75-3 ]
[ 6333-79-5 ]
(Z)-4-chloro-N-(2-((N,4-dimethylphenyl)sulfonamido)vinyl)-N-methylbenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique;	3 Example 3 Add 0.1 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.2 mmol), N-methyl-p-chlorobenzenesulfonamide (0.4 mmol) and a stirrer, then add 1 mL of dimethyl sulfoxide, and finally stopper the bottle with a soft rubber stopper, and react at room temperature for 24 hours, TLC point Plate detection; after the reaction is completed, after the reaction is completed, the pure product is obtained by column chromatography to give a white solid, yield 94%.
94%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0002
[2]Peng, Zhiyuan; Zhang, Zhenming; Tu, Yongliang; Zeng, Xianzhu; Zhao, Junfeng [Organic Letters, 2018, vol. 20, # 18, p. 5688 - 5691]

19
[ 497-25-6 ]
[ 1005500-75-3 ]
(Z)-N,4-dimethyl-N-(2-(2-oxooxazolidin-3-yl)vinyl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 32h; Schlenk technique;	4 Example 4 Add 0.1 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.2 mmol), 2-oxazolidinone (0.4 mmol) and a stirrer, then add 1 mL of dimethyl sulfoxide, and finally stopper the bottle with a soft rubber stopper, react at room temperature for 32 hours, and detect by TLC dot plate; After completion of the reaction, after completion of the reaction, the product was isolated by column chromatography to yield white solid, yield 76%.
76%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 32h; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0003
[2]Peng, Zhiyuan; Zhang, Zhenming; Tu, Yongliang; Zeng, Xianzhu; Zhao, Junfeng [Organic Letters, 2018, vol. 20, # 18, p. 5688 - 5691]

20
[ 120-72-9 ]
[ 1005500-75-3 ]
(Z)-N-(2-(1H-indol-1-yl)vinyl)-N,4-dimethylbenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 7h; Schlenk technique; stereoselective reaction;
82%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 6h; Schlenk technique;	5 Example 5 Add 0.1 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.2mmol), indole(0.4mmol) and a stir bar,Then add 1mL of dimethyl sulfoxide,Finally, plug the bottle with a soft rubber plug.React at room temperature for 6 hours,TLC dot plate inspection;After the reaction is completed, after the reaction is completed, the pure product is obtained by column chromatography., white solid, yield 82%.

Reference： [1]Peng, Zhiyuan; Zhang, Zhenming; Tu, Yongliang; Zeng, Xianzhu; Zhao, Junfeng [Organic Letters, 2018, vol. 20, # 18, p. 5688 - 5691]
[2]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0004

21
[ 1005500-75-3 ]
[ 4559-70-0 ]
(Z)-N-(2-(diphenylphosphoryl)vinyl)-N,4-dimethylbenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With tetrabutyl ammonium fluoride; caesium carbonate In acetonitrile at 20℃; Schlenk technique;	6 Example 6 Add 0.3 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.1 mmol), diphenylphosphine oxide (0.3 mmol), and tetrabutylammonium fluoride (0.02 mmol) and a stirrer, then 1 mL of acetonitrile was added, and finally the stopper was stoppered with a soft rubber stopper and reacted at room temperature. HLC, dot plate detection; after the reaction is completed, after the reaction is completed, the pure product is obtained by column chromatography, white solid, yield 83%
83%	With tetrabutyl ammonium fluoride; caesium carbonate In acetonitrile at 20℃; for 7h; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0005
[2]Peng, Zhiyuan; Tu, Yongliang; Zeng, Xianzhu; Zhang, Zhenming; Zhao, Junfeng [Advanced synthesis and catalysis, 2019]

22
[ 1005500-75-3 ]
[ 762-04-9 ]
diethyl (Z)-(2-((N,4-dimethylphenyl)sulfonamido)vinyl)phosphonate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 24h; Schlenk technique;	8 Example 8 Add 0.2 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.2 mmol), diethyl phosphite (0.1 mmol) and a stirrer, then 1 mL of dimethyl sulfoxide was added, and finally the bottle was stoppered with a soft rubber stopper, and reacted at room temperature for 24 hours, and detected by TLC dot plate; After completion, after completion of the reaction, separation was carried out by column chromatography to give a pure product as a colorless oily liquid, yield 91%.
83%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 2h; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0007
[2]Peng, Zhiyuan; Tu, Yongliang; Zeng, Xianzhu; Zhang, Zhenming; Zhao, Junfeng [Advanced synthesis and catalysis, 2019]

23
[ 1005500-75-3 ]
[ 829-85-6 ]
(Z)-N-(2-(diphenylphosphanyl)vinyl)-N,4-dimethylbenzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
80%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 0.166667h; Schlenk technique; Inert atmosphere;	9 Example 9 Add 0.1 mmol of cesium carbonate to the clean Schlenk reaction tube, N-methyl-N-ethynyl p-toluenesulfonamide(0.2 mmol), diphenylphosphine (0.24 mmol) and a stir bar, then stopper the bottle with a soft rubber stopper, a pipe connected to a nitrogen-filled balloon, and three times the Schlenk reaction tube, then add 1 mL of dimethylsulfoxide . Yafeng, reacted at room temperature for 10 minutes, TLC dot plate detection; after the reaction is completed, the pure product is obtained by column chromatography, colorless oily liquid, yield 80%.
80%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 0.166667h; Inert atmosphere; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0008
[2]Peng, Zhiyuan; Tu, Yongliang; Zeng, Xianzhu; Zhang, Zhenming; Zhao, Junfeng [Advanced synthesis and catalysis, 2019]

24
[ 1005500-75-3 ]
[ 10504-92-4 ]
(Z)-N-(2-((N,4-dimethylphenyl)sulfonamido)vinyl)-4-methyl-N-(4-methylbenzyl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
77%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 32h; Schlenk technique;	2 Example 2 0.1 mmol of cesium carbonate, N-methyl-N-ethynyl p-toluenesulfonamide (0.2 mmol), N-4-methylbenzyl p-toluenesulfonamide (0.4 mmol) were added to the clean Schlenk reaction tube along with stirring, then 1mL of dimethyl sulfoxide was added, finally, the bottle mouth was stoppered with a soft rubber stopper, and reacted at room temperature for 32 hours, and monitored by TLC point board ; after completion of the reaction, the product was isolated by column chromatography to give a white solid (yield: 77%).
70%	With caesium carbonate In dimethyl sulfoxide at 20℃; for 32h; Schlenk technique; stereoselective reaction;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108383759, 2018, A Location in patent: Paragraph 0001
[2]Peng, Zhiyuan; Zhang, Zhenming; Tu, Yongliang; Zeng, Xianzhu; Zhao, Junfeng [Organic Letters, 2018, vol. 20, # 18, p. 5688 - 5691]

25
[ 1005500-75-3 ]
[ 40473-50-5 ]
[ 81-23-2 ]
2-(3-((N,4-dimethylphenyl)sulfonamido)-3-oxo-1-phenylpropyl)phenyl (4R)-4-((5S,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3,7,12-trioxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate [ No CAS ]

Reference： [1]Chemical Communications,2018,vol. 54,p. 11753 - 11756

26
[ 4617-33-8 ]
[ 1005500-75-3 ]
1-(N,4-dimethylphenylsulfonylamino)vinyl 15-hydroxypentadecanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With copper(l) chloride In dichloromethane at 20℃; for 24h;	3 Example 3, General procedure: Add alkyne amide (0.20mmol), 12-hydroxyalkanoic acid (0.2mmol) to a clean 4mL reaction tube, add 10mol% CuCl, add 2mL CH2Cl2 as solvent, react at room temperature for 24h, detect by TLC dot plate, solvent after reaction Concentrated and column chromatography to obtain a pure product. White solid, yield 91%
90%	With copper(l) chloride In dichloromethane at 20℃;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0003
[2]Wang, Xuewei; Yang, Ming; Zhao, Junfeng [ACS Catalysis, 2020, vol. 10, # 9, p. 5230 - 5235]

27
[ 1005500-75-3 ]
[ 141-22-0 ]
C₂₈H₄₅NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With copper(l) cyanide In dichloromethane at 20℃; for 4h;	4 Example 4, General procedure: Add alkyne amide (0.20 mmol) and 12-hydroxyalkanoic acid (0.2 mmol) to a clean 4 mL reaction tube, add 10 mol% CuCN, add 2 mL CH2Cl2 as solvent, react at room temperature for 4 h, detect by TLC dot plate, and solvent after the reaction Concentrated and column chromatography to obtain a pure product. White solid, yield 91%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0004

28
[ 1005500-75-3 ]
[ 765-01-5 ]
C₂₀H₂₉NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With copper(l) chloride; In dichloromethane; at 20.0℃; for 4.0h;	Add alkynamide(0.20 mmol), <strong>[765-01-5]10-hydroxy-2-decenoic acid</strong> (0.2 mmol) to a clean 25 mL reaction tube, add 10 mol% CuCl, add 4 mL of CH2Cl2 as a solvent, react at room temperature for 4 h, and detect by TLC dot plate. After the reaction, the solvent is concentrated and column chromatography is carried out to obtain a pure product. White solid, yield 91%.

Reference： [1]ACS Catalysis,2020,vol. 10,p. 5230 - 5235
[2]Patent: CN108640861,2018,A .Location in patent: Paragraph 0005

29
[ 1005500-75-3 ]
[ 934813-05-5 ]
C₂₄H₃₇NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
91%	With copper(l) chloride In dichloromethane at 20℃; for 4h;	6 Example 6, Add alkynamide(0.20 mmol), (E)-14-hydroxy-2-14 enoic acid (0.2 mmol) to a clean 4 mL reaction tube, add 4 mL of CH2Cl2 as a solvent, add 10 mol% CuCl, and react at room temperature for 4 h, TLC Spot plate detection, after completion of the reaction, the solvent was concentrated and subjected to column chromatography to give a pure product as a white solid, yield 91%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0006

30
[ 1005500-75-3 ]
2-(3-(2-hydroxyethoxy)propyl)benzoic acid [ No CAS ]
1-(N,4-dimethylphenylsulfonylamino)vinyl 2-(3-(2-hydroxyethoxy)propyl)benzoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
100%	With copper(l) cyanide In dichloromethane at 20℃; for 4h;	7 Example 7, Add alkynamide(0.20 mmol), 2-(3-(2-hydroxyethoxy)propyl)benzoic acid (0.2 mmol) to a clean 4 mL reaction tube, add 4 mL of CH2Cl2 as a solvent, and add 10 mol% CuCN. The reaction was carried out for 4 h at room temperature, and the TLC plate was used for the detection. After the reaction, the solvent was concentrated and column chromatography was carried out to obtain a pure product. White solid, yield 100%.
92%	In dichloromethane at 20℃;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0007
[2]Wang, Xuewei; Yang, Ming; Zhao, Junfeng [ACS Catalysis, 2020, vol. 10, # 9, p. 5230 - 5235]

31
[ 1005500-75-3 ]
2-(7-hydroxyheptyl)benzoic acid [ No CAS ]
C₂₄H₃₁NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With copper(l) chloride In dichloromethane at 20℃; for 4h;	8 Example 8, Add alkynamide(0.20mmol), 2-(7-hydroxyheptyl)benzoic acid (0.2mmol) to a clean 4mL reaction tube, add 4mL CH2Cl2 as solvent, add 10mol% CuCl, react at room temperature for 4h, TLC point plate After the end of the reaction, the solvent was concentrated and subjected to column chromatography to give a pure product as a white solid, yield 94%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0008

32
[ 1005500-75-3 ]
4-(11-hydroxyundec-1-yn-1-yl)benzoic acid [ No CAS ]
C₂₈H₃₅NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90%	With copper(l) chloride In dichloromethane at 20℃; for 4h;	9 Example 9, Add alkynamide(0.20 mmol), 4-(11-hydroxyundec-1-yn-1-yl)benzoic acid (0.2 mmol) to a clean 4 mL reaction tube, add 4 mL of CH2Cl2 as solvent, and add 10 mol% CuCl. , reacted at room temperature for 4 h, detected by TLC dot plate, after the reaction is finished, the solvent is concentrated and column chromatography is carried out to obtain a pure product. White solid, yield 90%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0009

33
[ 144649-40-1 ]
[ 1005500-75-3 ]
C₃₁H₄₄N₂O₆S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With copper(l) iodide In dichloromethane at 20℃; for 4h;	10 Example 10, Add alkynamide(0.20 mmol), (S)-2-(12-hydroxydodecanoylamino)-3-phenylpropionic acid (0.2 mmol) to a clean 4 mL reaction tube, and add 4 mL of CH2Cl2 as solvent. 10 mol% CuCl, reacted at room temperature for 4 h, detected by TLC dot plate, solvent concentration after column chromatography and column chromatography to obtain pure product, white solid, yield 89%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0010

34
[ 1005500-75-3 ]
(S)-2-((S)-3-hydroxy-2-((9Z,12S)-12-hydroxyoctadec-9-enamido)propanamido)-4-methylpentanoic acid [ No CAS ]
C₃₇H₆₁N₃O₈S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With copper(l) iodide In dichloromethane at 20℃; for 4h;	11 Example 11, Add alkynamide(0.20 mmol), (S)-2-((S)-3-hydroxy-2-((9Z,12S)-12-hydroxyoctadec-9-enamido)propanamido)-4-methylpentanoic acid (0.2 mmol) to a clean reaction tube, adding 4 mL of CH2Cl2 as solvent, adding 10 mol% of CuI, reacting at room temperature for 4 h, detecting by TLC dot plate, solvent concentration after column chromatography and pure by column chromatography Product, white solid, yield 94%

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0011

35
[ 1005500-75-3 ]
(S)-2-{2-[(S)-2-[(9Z,12S)-12-hydroxyoctadec-9-enamido]propanamido]acetamido}-4-methylpentanoic acid [ No CAS ]
C₃₉H₆₄N₄O₈S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	With copper(l) chloride In dichloromethane at 20℃; for 4h;	12 Example 12, Add alkynamide(0.20 mmol) to a clean 4 mL reaction tube, (S)-2-{2-[(S)-2-[(9Z,12S)-12-hydroxyoctadec-9-enamido]propanamido]acetamido}-4-methylpentanoic acid (0.2mmol), adding 4mL CH2Cl2 as solvent, adding 10mol% CuCl, reacting at room temperature for 4h, detecting by TLC dot plate, solvent concentration after column reaction and column chromatography to obtain pure product. White solid, yield 93%

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0012

36
[ 3710-42-7 ]
[ 1005500-75-3 ]
[ 539-87-7 ]
[ 16697-83-9 ]

Reference： [1]Patent: CN108640861,2018,A

37
[ 3710-42-7 ]
[ 1005500-75-3 ]
1-(N,4-dimethylphenylsulfonylamino)vinyl 7-hydroxyheptanoate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	With copper(l) chloride; In dichloromethane; at 20℃; for 24h;	General procedure: Add alkyne amide (0.22mmol), <strong>[3710-42-7]7-hydroxyheptanoic acid</strong> (0.2mmol) to a clean 4mL reaction flask, add 10mmol% CuCl catalyst, add 2mL CH2Cl2 as solvent, react at room temperature for 24h, detect by TLC plate, after the reaction is over. The solvent is concentrated and column chromatography to obtain a pure product.White solid, yield 92%.

Reference： [1]Patent: CN108640861,2018,A .Location in patent: Paragraph 0001
[2]ACS Catalysis,2020,vol. 10,p. 5230 - 5235

38
[ 1005500-75-3 ]
12-hydroxydodecanamido-4-methylpentanoic acid [ No CAS ]
[ 16697-83-9 ]
C₁₈H₃₃NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
92%	Stage #1: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine; 12-hydroxydodecanamido-4-methylpentanoic acid With copper(l) chloride In dichloromethane at 20℃; for 2h; Stage #2: With toluene-4-sulfonic acid In dichloromethane for 4h;	20 Example 20, In a clean 25 mL round bottom flask, (12-hydroxydodecanamido-4-methylpentanoic acid (0.20 mmol) was added, 10moL CH2Cl2 was added as solvent, alkynamide (0.20 mmol) , 10 mol% CuCl were added and reacted at room temperature for 2 h, TLC dot plate detection, after the reaction was completed, 15 mol% of p-toluenesulfonic acid was added, and after reacting for 4 hours, the solvent was concentrated and subjected to column chromatography to obtain a pure product, a colorless liquid, yield: 92%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0020

39
[ 1005500-75-3 ]
[(2S,11E,14S)-14-hydroxy-3-oxo-1-phenylicos-11-en-2-yl]carbamic acid [ No CAS ]
[ 16697-83-9 ]
C₂₇H₄₁NO₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	Stage #1: N-(methyl)-N-(p-toluenesulfonyl)ethynylamine; [(2S,11E,14S)-14-hydroxy-3-oxo-1-phenylicos-11-en-2-yl]carbamic acid With copper(l) chloride In dichloromethane at 20℃; for 2h; Stage #2: With toluene-4-sulfonic acid In dichloromethane for 4h;	21 Example 21, In a clean 25mL round bottom flask, [(2S,11E,14S)-14-hydroxy-3-oxo-1-phenylicos-11-en-2-yl]carbamic acid(0.20 mmol) was added, 10 mL of CH2CI2 was added as solvent, alkynamide (0.20mmol) and 10 mol% CuCl were added, after reacting at room temperature for 2 h, TLC dot plate was tested, and after the reaction was over, 15 mol% of p-toluenesulfonic acid was added, after 4 h of reaction, the solvent was concentrated and subjected to column chromatography to give a pure product as a colorless liquid, yield 85%.

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0021

40
[ 505-95-3 ]
[ 1005500-75-3 ]
C₂₂H₃₅NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	With copper(l) iodide In dichloromethane at 20℃; for 24h;	2 Example 2, General procedure: Add alkyne amide (0.22mmol), 12-hydroxyalkanoic acid (0.2mmol) to a clean 4mL reaction tube, add 10mol% CuI, add 2mL CH2Cl2 as solvent, react at room temperature for 24h, detect by TLC dot plate, solvent after reaction Concentrated and column chromatography to obtain a pure product. White solid, yield 93%.
87%	With copper(l) chloride In dichloromethane at 20℃;

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108640861, 2018, A Location in patent: Paragraph 0002
[2]Wang, Xuewei; Yang, Ming; Zhao, Junfeng [ACS Catalysis, 2020, vol. 10, # 9, p. 5230 - 5235]

41
[ 79-00-5 ]
[ 640-61-9 ]
[ 1005500-75-3 ]

Yield	Reaction Conditions	Operation in experiment
90%	With sodium hydride In N,N-dimethyl-formamide at 80℃; for 1h; Schlenk technique;	1 Example 1 0.2 mmol of N-methyl-p-toluenesulfonamide and a stir bar were added to a clean Schlenk reaction tube, and then 1.0 mL of DMF solvent was added by a syringe.Add 1.4 mmol of NaH to the reaction tube.Finally, 1.0 mmol of 1,1,2-trichloroethane was added using a micro syringe.Then, the bottle mouth was stoppered with a soft rubber stopper, and reacted at 80 ° C for 1 hour, and the TLC dot plate was tested;After the reaction was completed, the reaction solution was added with ice water and extracted with ethyl acetate three times.The organic layer was concentrated and then purified by column chromatography to yield90% purified N-methyl-N-ethynyl p-toluenesulfonamide as a white solid.The structural formula of the product and its characterization data are as follows:

Reference： [1]Current Patent Assignee: JIANGXI NORMAL UNIVERSITY - CN108689858, 2018, A Location in patent: Paragraph 0025

42
[ 1005500-75-3 ]
[ 101023-70-5 ]
methyl 4-(5-((N,4-dimethylphenyl)sulfonamido)-3-(methyl-(tosyl)carbamoyl)-4-(p-tolyl)-1H-pyrrol-2-yl)benzoate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 12157 - 12164

43
[ 1005500-75-3 ]
[ 101023-70-5 ]
methyl 4-(5-((N,4-dimethylphenyl)sulfonamido)isoxazol-3-yl)benzoate [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2019,vol. 84,p. 12157 - 12164

44
[ 3669-80-5 ]
[ 1005500-75-3 ]
C₂₁H₃₃NO₅S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
69%	With copper(l) chloride In dichloromethane at 20℃;

Reference： [1]Wang, Xuewei; Yang, Ming; Zhao, Junfeng [ACS Catalysis, 2020, vol. 10, # 9, p. 5230 - 5235]

45
[ 1530-88-7 ]
[ 1005500-75-3 ]
N,4-dimethyl-N-(2-(pyrrolidin-1-yl)oxazol-5-yl)benzenesulfonamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
66%	With [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene]gold bis(trifluoromethanesulfonyl)imidate; 2,3-dichloropyridine N-oxide In neat (no solvent) at 60℃; for 3h;

Reference： [1]Zimin, Dmitry P.; Dar'In, Dmitry V.; Kukushkin, Vadim Yu.; Dubovtsev, Alexey Yu. [Journal of Organic Chemistry, 2021, vol. 86, # 2, p. 1748 - 1757]

46
[ 1005500-75-3 ]
C₁₃H₁₀⁽²⁾HNO₂ [ No CAS ]
C₂₃H₂₁⁽²⁾HN₂O₄S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70%	With copper(II) bis(trifluoromethanesulfonate) In 1,2-dichloro-ethane at 45℃; for 2h; Molecular sieve; Schlenk technique; Inert atmosphere;	2. Typical Procedure for the Synthesis of 3 and 4 General procedure: An oven-dried 25 mL Schlenk tube was charged with N-aryl hydroxamic acid 2 (1.5 eq., 0.3 mmol), Cu(OTf)2 (20 mol %, 0.04 mmol) and 4Å MS (50 mg), and the tube was evacuated and purged with argon for three times. Anhydrous DCE (1 mL) was added, and then a DCE solution (1 mL) of ynamide 1 (1.0 eq., 0.2 mmol) was added dropwise via syringe over 30 min. After stirring at 45 °C for 2 h, the reaction mixture was filtered through a short Celite pad. The filtrate was concentrated and purified by flash column chromatography on silica gel using ethyl acetate/petroleum ether (v/v, 1:4 to 1:2) as eluent to afford the desired products 3 or 4.