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Chemical Structure| 1009378-44-2 Chemical Structure| 1009378-44-2

Structure of 1009378-44-2

Chemical Structure| 1009378-44-2

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Product Details of [ 1009378-44-2 ]

CAS No. :1009378-44-2
Formula : C11H10BrN3OS
M.W : 312.19
SMILES Code : O=C(C1=C(C)N=C(Br)S1)NCC2=CC=CN=C2

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Application In Synthesis of [ 1009378-44-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1009378-44-2 ]

[ 1009378-44-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1009378-44-2 ]
  • [ 376584-63-3 ]
  • [ 1009378-45-3 ]
YieldReaction ConditionsOperation in experiment
85% With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); In ethanol; water; toluene; at 100℃; for 16h; To a solution of 2-bromo-4-methyl-thiazole-5-carboxylic acid (pyridine-3- ylmethyl)-amide (5.0 g, 16.0 mmol) in toluene (30 mL), water (10 mL) and ethanol (10 mL) was added lH-pyrazole-5-boronic acid (2.15 g, 19.2 mmol), Pd(PPh3)4 (1.85 g, 1.60 mmol), and potassium carbonate (6.64 g, 48.1 mmol). The resulting mixture was degassed three times and heated to 1000C for 16 hr. The reaction mixture was cooled to room temperature, diluted with ethyl acetate (200 mL) and washed with brine (2 x 100 mL). The organic phase was dried (Na2SO4) and evaporated. The residue was recrystallized from ethyl acetate to provide 4-methyl-2-(2H-pyrazol-3-yl)-thiazole-5- carboxylic acid (pyridine-3-ylmethyl)amide as a white solid (4.20 g, 85percent yield).
 

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