Home Cart Sign in  
Chemical Structure| 1011527-96-0 Chemical Structure| 1011527-96-0

Structure of 1011527-96-0

Chemical Structure| 1011527-96-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1011527-96-0 ]

CAS No. :1011527-96-0
Formula : C13H10FN3
M.W : 227.24
SMILES Code : FC1=CC=CC=C1CC2=NNC3=CC=CN=C32

Safety of [ 1011527-96-0 ]

Application In Synthesis of [ 1011527-96-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1011527-96-0 ]

[ 1011527-96-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1920-66-7 ]
  • [ 1011527-96-0 ]
  • 2-[3-(2-fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
Example 11A 2-[3-(2-Fluorobenzyl)-1H-pyrazolo[4,3-b]pyridin-1-yl]-5-nitropyrimidine-4-amine 795 mg (3.50 mmol) of the compound from Example 10A were initially charged in DMF (19 ml), 154 mg (3.85 mmol) of sodium hydride (60% in mineral oil) were then added and the mixture was stirred at RT for 1 h. 580 mg (3.32 mmol) of <strong>[1920-66-7]2-chloro-5-nitropyrimidine-4-amine</strong> (J. Med. Chem. (1992), 35, 4455-4463) were then added, and the reaction mixture was stirred at 80 C. for another 2 h. The mixture was brought to RT and then added to water. The suspension obtained in this manner was filtered off and the solid was washed repeatedly with water and then dried under high vacuum. This gave 281 mg of the desired compound. The mother liquor, which still contained product, was extracted three times with ethyl acetate. The combined organic phases were dried over sodium sulfate, filtered and concentrated on a rotary evaporator. This gave a further 512 mg of the target compound. The crude product obtained in this manner was reacted without further purification. LC-MS (method 1): Rt=1.01 min; MS (EIpos): m/z=366 [M+H]+.
 

Historical Records

Technical Information

Categories