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Chemical Structure| 1015236-21-1 Chemical Structure| 1015236-21-1

Structure of 1015236-21-1

Chemical Structure| 1015236-21-1

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Product Details of [ 1015236-21-1 ]

CAS No. :1015236-21-1
Formula : C12H5Cl2FN4
M.W : 295.10
SMILES Code : FC1=CC=C(Cl)C=C1C2=NC(Cl)=C3N=CC=NC3=N2

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Application In Synthesis of [ 1015236-21-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1015236-21-1 ]

[ 1015236-21-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1015236-21-1 ]
  • [ 2247-88-3 ]
  • [ 849777-59-9 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;palladium diacetate; In 1,4-dioxane; at 100℃; for 20h; Example 11 Synthesis of Compound 46 Preparation of 46 : [0113] To A suspension of dioxane (15ml), Pd (OAC) 2 (LOOM), BINAP (100mg), 4-amino- 3-FLUORO-PYRIDINE (220mg) and CS2C03 (1. 0 G) was added the crude imino chloride, xxx (500 MG) in A sealed tube. The reaction mixture was heated to 100°C for 20 H. The reaction mixture was cooled to R. t. and filtered through CELITE and the crude material was purified by silica gel flash column chromatography (95percent to 5percent gradient CH2CL2/ETOAC) to afford [2- (5-CHLORO-2- FLUORO-PHENYL)-PTERIDIN-4-YL]-(3-FLUORO-PYRIDIN-4-YL)-AMINE (200 MG).
 

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