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Chemical Structure| 1016769-81-5 Chemical Structure| 1016769-81-5

Structure of 1016769-81-5

Chemical Structure| 1016769-81-5

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Product Details of [ 1016769-81-5 ]

CAS No. :1016769-81-5
Formula : C11H12BrNO
M.W : 254.12
SMILES Code : O=C1CCN(C2=CC=CC(Br)=C2)CC1
MDL No. :MFCD09933024

Safety of [ 1016769-81-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 1016769-81-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1016769-81-5 ]

[ 1016769-81-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1016769-81-5 ]
  • [ 628692-15-9 ]
  • 1-(3-(2-methoxypyrimidin-5-yl)phenyl)piperidin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% With potassium phosphate; tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 100℃; for 12h;Inert atmosphere; To a solution of 1 -(3 -bromophenyl)piperidin-4-one 1403 (10.0 g, 39.4 mmol, 1.00 eq) in dioxane(80 mL) and H20 (20 mL) was added <strong>[628692-15-9](2-methoxypyrimidin-5-yl)boronic acid</strong> (6.1 g, 39.4 mmol,1.00 eq), Pd(PPh3)4 (2.3 g, 2.0 mmol, 0.05 eq) and K3P04 (12.5 g, 59.0 mmol, 1.50 eq). The mixture was stirred at 100°C for 12 h under N2 atmosphere and reaction progress was monitored by LCMS. The mixture was filtered over diatomite and the filtrate poured into H20 (200 mL) and extracted with ethyl acetate (3 x 200 mL). The combined organic layers were concentratedunder reduced pressure and the resulting residue was taken up in petroleum ether/ethyl acetate =10/1 (100 mL). The suspension was filtered and the filter cake collected and dried under reducedpressure to give 1-(3-(2-methoxypyrimidin-5-yl)phenyl)- piperidin-4-one 1404 (8 g, 72 percent yield)as a yellow solid. ?H NMR: (400IVIHz, MeOD-d4) oe = 8.81 - 8.78 (m, 2H), 7.38 - 7.34 (m, 1H),7.17 - 7.12 (m, 1H), 7.10 - 7.02 (m, 2H), 4.05 (s, 3H), 3.70 (t, J= 5.6 Hz, 2H), 3.37 - 3.30 (m,2H), 2.55 (t, J= 6.0 Hz, 2H), 1.92 - 1.82 (m, 1H).
 

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• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

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