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Chemical Structure| 101999-45-5 Chemical Structure| 101999-45-5

Structure of 101999-45-5

Chemical Structure| 101999-45-5

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Product Details of [ 101999-45-5 ]

CAS No. :101999-45-5
Formula : C11H9NO4
M.W : 219.19
SMILES Code : O=C(N)CC(C1=C(O2)C=C(O)C=C1)=CC2=O
MDL No. :MFCD06001840

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Application In Synthesis of [ 101999-45-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 101999-45-5 ]

[ 101999-45-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1700-31-8 ]
  • [ 101999-45-5 ]
  • C25H21NO5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 70℃; for 2h; 4-[(AminocarbonyI)raethyI]-7-(3-hydroxybenzyIoxy)-2H-chromen-2-oneA solution of 0.43 g (1.95 mmol) of 4-[(aminocarbonyl)methyl]-7-hydroxy-2H- chromen-2-one, 5.7 g (19.5 mmol) (3-benzoyloxy)benzyl bromide and 2.5 g (19.5 mmol) of diisopropylethylamine in 50 ml of anhydrous THF, was stirred at 70 0C for 2 hours. The mixture was then cooled to room temperature, the solid which formed was filtered off, 1.5 ml of saturated methanolic sodium methylate solution was added and the whole mixture was stirred for 4 hours. After evaporation of the solvent under vacuum, the residue was taken up in 30 ml of ethyl acetate and 5 ml of 1 N HCl, the organic phase was separated, washed with brine and dried over anhydrous sodium sulphate. After evaporation of the solvent under vacuum, the yellow solid residue was purified by column chromatography on silica gel (eluant CH2CIaZMeOH 8.5/1.5 v/v) to give the title compound in 30percent yield. * Mp (dec.) 190-191 0C. 1H-NMR (DMSO-d6) delta: 9.51 (s, IH); 7.66-7.63(m, 2H); 7.18-6.99 (m, 4H); 6.85-6.81 (m, 2H); 6.70-6.68 (m, IH); 6.23 (s, IH); 5.13 (s, 2H); 3.62 (s, 2H).
 

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