Name: 102-39-6|2,2'-(1,3-Phenylenebis(oxy))diacetic acid|98%
Brand: Ambeed
SKU: A627413
Rating: 99 (27 reviews)

1
[ 110-63-4 ]
[ 102-39-6 ]
1,4,9,12-tetraoxa-[12]metacyclophane-3,10-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 200℃; Erhitzen des Reaktionsgemisches mit Zinn(II)-chlorid-dihydrat unter 1 Torr auf 270grad;

Reference： [1]Spanagel; Carothers [Journal of the American Chemical Society, 1935, vol. 57, p. 935]

2
[ 629-11-8 ]
[ 102-39-6 ]
[ 26736-14-1 ]

Yield	Reaction Conditions	Operation in experiment
	at 200℃; Erhitzen des Reaktionsgemisches mit Zinn(II)-chlorid-dihydrat unter 1 Torr auf 270grad;

Reference： [1]Spanagel; Carothers [Journal of the American Chemical Society, 1935, vol. 57, p. 935]

3
[ 112-47-0 ]
[ 102-39-6 ]
1,4,15,18-tetraoxa-[18]metacyclophane-3,16-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 200℃; Erhitzen des Reaktionsgemisches mit Zinn(II)-chlorid-dihydrat unter 1 Torr auf 270grad;

Reference： [1]Spanagel; Carothers [Journal of the American Chemical Society, 1935, vol. 57, p. 935]

4
[ 3937-56-2 ]
[ 102-39-6 ]
1,4,14,17-tetraoxa-[17]metacyclophane-3,15-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 200℃; Erhitzen des Reaktionsgemisches mit Zinn(II)-chlorid-dihydrat unter 1 Torr auf 270grad;

Reference： [1]Spanagel; Carothers [Journal of the American Chemical Society, 1935, vol. 57, p. 935]

5
[ 15470-55-0 ]
[ 102-39-6 ]
[4-(2,5-dichloro-phenylazo)-m-phenylenedioxy]-di-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With acetic acid

Reference： [1]Ettel et al. [Collection of Czechoslovak Chemical Communications, 1950, vol. 15, p. 204,213,214]

6
[ 726-42-1 ]
[ 102-39-6 ]
m-phenylenedioxy-di-acetic acid bis-(N,N'-di-p-tolyl ureide) [ No CAS ]

Reference： [1]Zetzsche; Luescher; Meyer [Chemische Berichte, 1938, vol. 71, p. 1088,1091]

7
[ 102-39-6 ]
[ 67045-26-5 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride
	With thionyl chloride
	With thionyl chloride; triethylamine In dichloromethane

	With thionyl chloride; triethylamine In dichloromethane for 4h; Reflux;	General procedure for the synthesis of bis-oxy acid chlorides 10-18 General procedure: A mixture of the the diacid (1.54 mmol), thionylchloride (1.8 mL) and triethylamine (0.5 mL) in dichloromethane (80 mL) was refluxed for 4 h. The solvent was removed under reduced pressure to give the corresponding diacid chloride.
	With thionyl chloride Reflux;	General procedure: The 2-amino-5-mercapto-1,3,4-thiadiazole 1 (5 mmol) was dissolved in NaOH(5 mmol, 15 mL) at room temperature. Ethyl 2-bromopropionate (5 mmol) was addedto the solution obtained and the mixture was stirred for 20 min. After that, the solid precipitatewas filtered off, washed with cold water, air dried, and then recrystallized from ethanolto give 2-(5-amino-1,3,4-thiadiazol-2-ylthio) propanoate 2 in 78% yield as pale yellowsolid. Mp 79-80C; 1H NMR(CDCl3, 400 MHz) δH: 1.25-1.28 (t, 3H, CH3, J = 6.0 Hz),1.57-1.59 (d, 3H, CH3, J = 8.0 Hz), 4.03-4.08 (q, 1H, SCH, J = 12.0 Hz), 4.16-4.22(q, 2H, OCH2, J = 16.0 Hz).4.35 (s, 2H, NH2); 13C NMR (CDCl3, 400 MHz) δC: 14.0,17.5, 46.0, 61.8, 150.0, 170.9, 171.4; IR (KBr) ν: 3266 (NH2), 1736 (OC O), 1501,1449, 1321, 1094 (C N N C S) cm-1; Anal. calcd for C7H11N3O2S2: C36.04, H 4.75,N 18.01; found C 36.10, H 4.77, N 17.93.To a 50 mL round-bottom flask was added phenoxyalkanoic acid 4 (5 mmol) andSOCl2 (5 mL). The mixture was refluxed for 4 h, and the excess SOCl2 was removedunder vacuum. The crude diacyl chloride was dissolved in CH3CN (5 mL) and addeddropwise through a dropping funnel to themixture of 2-(5-amino-1,3,4-thiadiazol-2-ylthio)propanoate 2 (4.5 mmol) and Et3N (4.2 mL, 30 mmol) in CH3CN (15 mL) on an ice bath.This mixture was vigorously stirred at room temperature for an additional 12 h aftercompletion of the addition. The product was evaporated under reduced pressure washedwith water and brine, dried and recrystallized from ethanol to give the title compounds 6.
	With thionyl chloride In benzene for 6h; Reflux;

Reference： [1]Bischoff; Froehlich [Chemische Berichte, 1907, vol. 40, p. 2781]
[2]Borowitz, Irving J.; Readio, Josephine D.; Li, Ven-Shun [Tetrahedron, 1984, vol. 40, # 6, p. 1009 - 1016]
[3]Location in patent: body text Rajakumar, Perumal; Padmanabhan, Ramar [ARKIVOC, 2012, vol. 2012, # 6, p. 155 - 163]
[4]Rajakumar, Perumal; Padmanabhan, Ramar; Rajesh, Navin [Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 11, p. 3770 - 3775]
[5]Hu, Bing; Zhai, Yue-Yuan; Zhang, Ling; Zhang, You-Ming; Wei, Tai-Bao [Phosphorus, Sulfur and Silicon and the Related Elements, 2014, vol. 189, # 9, p. 1337 - 1345]
[6]Panja, Atanu; Ghosh, Kumaresh [New Journal of Chemistry, 2019, vol. 43, # 2, p. 934 - 945]

8
[ 102-39-6 ]
[ 85784-34-5 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid

Reference： [1]Ettel et al. [Collection of Czechoslovak Chemical Communications, 1950, vol. 15, p. 204,213,214]

9
[ 102-39-6 ]
[ 262861-51-8 ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuryl dichloride; acetic acid

Reference： [1]Moszew; Wojciechowski [Roczniki Chemii, 1954, vol. 28, p. 445,450][Chem.Abstr., 1955, p. 13147]

10
[ 102-39-6 ]
(2,4,6-trinitro-m-phenylenedioxy)-di-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With water; nitric acid

Reference： [1]Carter; Lawrence [Journal of the Chemical Society, 1900, vol. 77, p. 1224]

11
[ 66644-04-0 ]
[ 102-39-6 ]

Yield	Reaction Conditions	Operation in experiment
92%	With water; lithium hydroxide In tetrahydrofuran at 20℃; for 2h;
88%	With lithium hydroxide In tetrahydrofuran; water at 20℃; for 24h;	Synthesis of compound 2 To a soln of 1 (2 g, 7.0 mmol) in THF-H2O (10:1, 25 mL), was added LiOH (0.73 g, 17.5 mmol) and the soln was stirred at rt for 24 h. The reaction mixture was acidified using 2N HCl and was extracted with ethyl acetate (2 × 25 mL). The organic layer was washed with water (15 mL), dried over Na2SO4, filtered and evaporated to give 1.4 g (88 %) of compound 2 as a white solid.
	bei der Verseifung;

With water; potassium hydroxide In ethanol Reflux;

Reference： [1]Panja, Atanu; Ghosh, Kumaresh [New Journal of Chemistry, 2019, vol. 43, # 2, p. 934 - 945]
[2]Tripathi, Anamica; Kumar, Anjul; Pandey, Pramod S. [Tetrahedron Letters, 2012, vol. 53, # 43, p. 5745 - 5748]
[3]Carter; Lawrence [Journal of the Chemical Society, 1900, vol. 77, p. 1224]
[4]Location in patent: body text Rajakumar, Perumal; Padmanabhan, Ramar [ARKIVOC, 2012, vol. 2012, # 6, p. 155 - 163]

12
[ 102-39-6 ]
[ 107-21-1 ]
1,4,7,10-tetraoxa-[10]metacyclophane-3,8-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 200℃; Erhitzen des Reaktionsgemisches mit Zinn(II)-chlorid-dihydrat unter 1 Torr auf 270grad;

Reference： [1]Spanagel; Carothers [Journal of the American Chemical Society, 1935, vol. 57, p. 935]

13
furan-2,3,5(4H)-trione pyridine (1:1) [ No CAS ]
[ 79-11-8 ]
[ 108-46-3 ]
[ 102-39-6 ]

Reference： [1]Gabriel [Chemische Berichte, 1879, vol. 12, p. 1640]

14
[ 79-11-8 ]
[ 108-46-3 ]
[ 102-39-6 ]

Yield	Reaction Conditions	Operation in experiment
87%	With sodium hydroxide In water at 95 - 100℃; for 0.166667h; Microwave irradiation; Sonication; Green chemistry;	3.2.3. MW-US Method General procedure: In a 50 mL flask, 1mmol of phenol (1-15), the appropriate amount of chloroacetic acid (16) andsodium hydroxide (potassium carbonate for nipagins) and 5 mL of water were mixed.Number of moles of chloroacetic acid (16) and NaOH (K2CO3): 1.2 mmol (0.11 g) of 16 and 2.3 mmol of base for monophenols (1-9) 2.2 mmol (0.21 g) of 16 and 3.3 mmol of base for diphenols (10-12) 3.2 mmol (0.30 g) of 16 and 4.3 mmol of base for triphenols (13-15)A flask with carefully mixed reagents was placed in a MW-US reactor and the contents reactedunder SMUI conditions characterized by the following parameters: MW = 200 W, US = 800 Wat 95-100° C for 10 min. After the process was complete, concentrated hydrochloric acid wasadded to the reaction mixture until an acidic pH~3 was obtained, to isolate the free products. Theseparated precipitate was filtered off. The main product was purified by crystallization or columnchromatography using a mixture of chloroform and methanol (9:1 or 5:1) as an eluent.
76%	With sodium hydroxide In water at 95 - 100℃; for 4h;	2.3.1 Synthesis of (3-carboxymethoxy-phenoxy) acetic acid (H₂L) 11.0g (0.1mol) of resorcinol, 200mL of water and 20.0g (0.5mol) of solid sodium hydroxide were added into the three-necked flask. Mixed them till dissolved. Then 21.0g (0.22mol) of monochloroacetic acetic was added. The mixture was stirred for 4h and heated between 95 and 100°C. After cooling to the room temperature, it was acidified with 4mol/L of hydrochloric acid till pH=2-3. Then a large number of solid precipitated. The solid crude product was dissolved into the water (100mL) and the excess solvent was removed by filtration. Finally the filtrate was acidified with 4mol/L hydrochloric acid to obtain pH=2-3 and the solid precipitated. It was washed with water to obtain a pure white powder. The powder was placed in drying oven at 150°C for 3h before all the characterizations to remove the water. Yield: 76%, m.p: 191.5-192.0°C. IR (KBr, cm-1): υ(O-HO) 3253; υas(COO) 1761; υsym(COO) 1433. 1H NMR (CDCl3, ppm): 4.64 (m, 4H, -CH2-), 6.44-7.16 (m, 4H, Ar-H). Anal. Calc. for C10H10O6 (226.18g/mol): C, 53.11; H, 4.46%. Found: C, 53.07; H, 4.42%.
60%	With sodium hydroxide for 0.00666667h; microwave irradiation;

	With sodium hydroxide
	With sodium hydroxide In water
	With sodium hydroxide
	With sodium hydroxide

Reference： [1]Pawełczyk, Anna; Sowa-Kasprzak, Katarzyna; Olender, Dorota; Zaprutko, Lucjusz [Molecules, 2018, vol. 23, # 9]
[2]Sougoule, Aboubacar Sidiki; Mei, Zemin; Xiao, Xiao; Balde, Cheick Abdoul; Samoura, Salematou; Dolo, Arouna; Zhu, Dongsheng [Journal of Organometallic Chemistry, 2014, vol. 758, p. 19 - 24]
[3]Nagy, Gabriela; Filip, Sorin V.; Surducan, Emanoil; Surducan, Vasile [Synthetic Communications, 1997, vol. 27, # 21, p. 3729 - 3736]
[4]van Alphen [Recueil des Travaux Chimiques des Pays-Bas, 1927, vol. 46, p. 147] Carter; Lawrence [Journal of the Chemical Society, 1900, vol. 77, p. 1224] Gabriel [Chemische Berichte, 1879, vol. 12, p. 1640]
[5]Borowitz, Irving J.; Readio, Josephine D.; Li, Ven-Shun [Tetrahedron, 1984, vol. 40, # 6, p. 1009 - 1016]
[6]Location in patent: scheme or table Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50] Location in patent: scheme or table Mei, Qinggang; Yang, Jie; Peng, Yongle; Zhao, Zhigang [Journal of Chemical Research, 2011, vol. 35, # 7, p. 386 - 389]
[7]Hu, Bing; Zhai, Yue-Yuan; Zhang, Ling; Zhang, You-Ming; Wei, Tai-Bao [Phosphorus, Sulfur and Silicon and the Related Elements, 2014, vol. 189, # 9, p. 1337 - 1345]

15
[ 102-39-6 ]
[ 62-53-3 ]
[ 56970-61-7 ]

Yield	Reaction Conditions	Operation in experiment
	at 190℃;

Reference： [1]Bischoff; Froehlich [Chemische Berichte, 1907, vol. 40, p. 2781] Carter; Lawrence [Journal of the Chemical Society, 1900, vol. 77, p. 1224]

16
[ 102-39-6 ]
[ 504-63-2 ]
1,4,8,11-tetraoxa-[11]metacyclophane-3,9-dione [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	at 200℃; Erhitzen des Reaktionsgemisches mit Zinn(II)-chlorid-dihydrat unter 1 Torr auf 270grad;

Reference： [1]Spanagel; Carothers [Journal of the American Chemical Society, 1935, vol. 57, p. 935]

17
[ 102-39-6 ]
[ 40098-81-5 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogen

Reference： [1]Borowitz, Irving J.; Readio, Josephine D.; Li, Ven-Shun [Tetrahedron, 1984, vol. 40, # 6, p. 1009 - 1016]

18
[ 302-17-0 ]
[ 102-39-6 ]
{2-[1-(2,4-bis-carboxymethoxy-phenyl)-2,2,2-trichloro-ethyl]-5-carboxymethoxy-phenoxy}-acetic acid [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sulfuric acid

Reference： [1]Purohit; Shah [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 5, p. 618 - 622]

19
[ 1878-83-7 ]
[ 79-11-8 ]
[ 102-39-6 ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide Heating;

Reference： [1]Purohit; Shah [Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1999, vol. 38, # 5, p. 618 - 622]

Yield	Reaction Conditions	Operation in experiment
25.9 g (91%)		14 EXAMPLE 14 EXAMPLE 14 A 0.5 L benchtop oxidation apparatus was charged with 25 g of resorcinol bis(beta-hydroxyethyl)ether, 250 mL of water, 2.5 g of 5% Pd on carbon, and 0.05 g of antimony triacetate. The resulting mixture was stirred at 95° C. for 30 minutes and cooled to 85° C. A solution of 0.02 g of silver nitrate in 3 mL of water was added and the resulting mixture was stirred for 25 minutes while the mixture was let cool to 56° C. Sodium hydroxide (11.5 g) was added, and the mixture was warmed to 82° C. and oxygen was introduced into the mixture while it was vigorously stirred. The reaction mixture exothermed to 95° while oxygen was consumed. This temperature was maintained until the consumption of oxygen ceased (33 minutes). The catalyst was filtered from the hot mixture and the resulting filtrate was acidified with 7.5 mL of conc. H2 SO4. The initial filtrate was clear and colorless. The product separated from the acidified filtrate as colorless crystals. The yield was 25.9 g (91%) of 1,3-phenylenedioxydiacetic acid which was of greater than 99% purity.

26
[ 102-39-6 ]
[ 7732-18-5 ]
[ 7697-37-2 ]
(2,4,6-trinitro-m-phenylenedioxy)-di-acetic acid [ No CAS ]

Reference： [1]Carter; Lawrence [Journal of the Chemical Society, 1900, vol. 77, p. 1224]

Yield	Reaction Conditions	Operation in experiment
	at 190 - 210℃; Erhitzen des Reaktionsprodukts mit SnCl₂+2 H₂O unter 1 Torr auf 270grad;

28
[ 102-39-6 ]
[ 2231-57-4 ]
5,5'-[1,3-phenylenebis(oxymethylene)]bis(4-amino-3-mercapto-1,2,4-triazole) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
81%	at 180℃; for 0.166667h;
78%	In neat (no solvent) at 180℃; for 0.166667h;

Reference： [1]Ghorab; El-Sharief; Ammar; Mohamed [Il Farmaco, 2000, vol. 55, # 5, p. 354 - 361]
[2]Sarhan, Radwan M.; Badawy, Mohamed A.; Elwahy, Ahmed H. M. [Journal of Heterocyclic Chemistry, 2014, vol. 51, # SUPPL. 1, p. E176-E182]

29
[ 102-39-6 ]
[ 89806-99-5 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SOCl₂ 2: 86 percent / Et₃N / CH₂Cl₂

Reference： [1]Borowitz, Irving J.; Readio, Josephine D.; Li, Ven-Shun [Tetrahedron, 1984, vol. 40, # 6, p. 1009 - 1016]

30
[ 102-39-6 ]
[ 137-19-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SO₂Cl₂; acetic acid 2: pyridine hydrochloride / 190 - 195 °C

Reference： [1]Moszew; Wojciechowski [Roczniki Chemii, 1954, vol. 28, p. 445,450][Chem.Abstr., 1955, p. 13147]

31
[ 102-39-6 ]
[ 2639-79-4 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: SO₂Cl₂; acetic acid 2: pyridine hydrochloride / 190 - 195 °C 3: aqueous NaOH

Reference： [1]Moszew; Wojciechowski [Roczniki Chemii, 1954, vol. 28, p. 445,450][Chem.Abstr., 1955, p. 13147]

32
[ 102-39-6 ]
(2,4-dichloro-5-hydroxy-phenoxy)-acetic acid ethyl ester [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 4 steps 1: SO₂Cl₂; acetic acid 2: pyridine hydrochloride / 190 - 195 °C 3: aqueous NaOH 4: ethanolic H₂SO₄

Reference： [1]Moszew; Wojciechowski [Roczniki Chemii, 1954, vol. 28, p. 445,450][Chem.Abstr., 1955, p. 13147]

33
[ 102-39-6 ]
[ 262861-52-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: SO₂Cl₂; acetic acid 2: methanol. H₂SO₄

Reference： [1]Moszew; Wojciechowski [Roczniki Chemii, 1954, vol. 28, p. 445,450][Chem.Abstr., 1955, p. 13147]

34
disodium resorcinolate [ No CAS ]
[ 102-39-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: alcohol 2: bei der Verseifung

Reference： [1]Carter; Lawrence [Journal of the Chemical Society, 1900, vol. 77, p. 1224]

35
[ 719261-06-0 ]
[ 102-39-6 ]
Ni⁽²⁺⁾*(C₆H₄(OCH₂COO)2)^(2-)*16H₂O = Ni(C₆H₄(OCH₂COO)2)*16H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With water In water NiCO3 was dissolved in hot aq. benzene-1,3-dioxyacetic acid; filtered, crystd. at room temp., dried in air at 303 K; elem. anal.;

Reference： [1]Brzyska, W.; Krol, A. [Thermochimica Acta, 1994, vol. 237, p. 111 - 118]

36
[ 102-39-6 ]
[ 759403-02-6 ]
Co⁽²⁺⁾*(C₆H₄(OCH₂COO)2)^(2-)*15H₂O = Co(C₆H₄(OCH₂COO)2)*15H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With water In water CoCO3 was dissolved in hot aq. benzene-1,3-dioxyacetic acid; filtered, crystd. at room temp., dried in air at 303 K; elem. anal.;

Reference： [1]Brzyska, W.; Krol, A. [Thermochimica Acta, 1994, vol. 237, p. 111 - 118]

37
[ 879089-16-4 ]
[ 102-39-6 ]
2Cu⁽²⁺⁾*C₆H₄(OCH₂COO)2^(2-)*2CH₃COO^(1-)=Cu₂(C₆H₄(OCH₂COO)2)(CH₃COO)2 [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In water diacid abd Cu2(OAc)4*2H2O were stirred in water at 60°C overnight; ppt. was filtered, washed with water and MeOH, and dried in vacuo at 100°C; elem. anal.;

Reference： [1]Bickley; Bonar-Law; Borrero Martinez; Steiner [Inorganica Chimica Acta, 2004, vol. 357, # 3, p. 891 - 894]

38
dirhodium tetraacetate [ No CAS ]
[ 102-39-6 ]
[ 694520-76-8 ]

Yield	Reaction Conditions	Operation in experiment
14%	In further solvent(s) under N2; soln. of acid and Rh complex in N,N-dimethylaniline stirred at140°C for 1-4 h; chromy.; elem. anal.;

Reference： [1]Bickley, Jamie; Bonar-Law, Richard; McGrath, Thomas; Singh, Nirmal; Steiner, Alexander [New Journal of Chemistry, 2004, vol. 28, # 3, p. 425 - 433]

39
[ 553-26-4 ]
[ 102-39-6 ]
[ 6156-78-1 ]
[Mn(3-carboxymethoxyphenylacrylic acid^(2-))(4,4'-bipyridine)0.5(H₂O)2]n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
43%	With NaOH In methanol; water High Pressure; mixt. of Mn(CH3CO2)2*4H2O, 3-carboxymethoxyphenylacrylic acid, NaOH and MeOH-H2O 1:4 placed in autoclave, heated at 433 K for 72 h, cooled to room temp. at 2°C/h; elem. anal.;

Reference： [1]Zheng, Xiao-Yong; Ye, Li-Qing; Wen, Yi-Hang [Journal of Molecular Structure, 2011, vol. 987, # 1-3, p. 132 - 137]

40
[ 553-26-4 ]
zinc(II) sulfate heptahydrate [ No CAS ]
[ 102-39-6 ]
[Zn(3-carboxymethoxyphenylacrylic acid^(2-))(4,4'-bipyridine)0.5]n [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
46%	With NaOH In methanol; water High Pressure; mixt. of ZnSO4*7H2O, 3-carboxymethoxyphenylacrylic acid, NaOH and MeOH-H2O 1:4 placed in autoclave, heated at 433 K for 72 h, cooled to room temp. at 2°C/h; elem. anal.;

Reference： [1]Zheng, Xiao-Yong; Ye, Li-Qing; Wen, Yi-Hang [Journal of Molecular Structure, 2011, vol. 987, # 1-3, p. 132 - 137]

41
[ 116346-35-1 ]
[ 102-39-6 ]
[ 1294004-73-1 ]

Yield	Reaction Conditions	Operation in experiment
86%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.133333h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

42
[ 1015792-86-5 ]
[ 102-39-6 ]
[ 1294004-76-4 ]

Yield	Reaction Conditions	Operation in experiment
81%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.166667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

43
[ 1028075-73-1 ]
[ 102-39-6 ]
[ 1294004-77-5 ]

Yield	Reaction Conditions	Operation in experiment
82%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.116667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

44
[ 102-39-6 ]
[ 223600-52-0 ]
[ 1294004-78-6 ]

Yield	Reaction Conditions	Operation in experiment
83%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.166667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

45
[ 102-39-6 ]
[ 223600-53-1 ]
[ 1294004-72-0 ]

Yield	Reaction Conditions	Operation in experiment
84%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.116667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

46
[ 102-39-6 ]
[ 618856-85-2 ]
[ 1294004-74-2 ]

Yield	Reaction Conditions	Operation in experiment
81%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.166667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

47
[ 102-39-6 ]
[ 618857-01-5 ]
[ 1294004-75-3 ]

Yield	Reaction Conditions	Operation in experiment
82%	With dmap; potassium carbonate; dicyclohexyl-carbodiimide for 0.166667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Zhao, Zhigang; Xia, Zhenyang; Li, Xiaorui; Shi, Peiyu [Journal of Chemical Research, 2011, vol. 35, # 1, p. 47 - 50]

48
[ 64-17-5 ]
[ 102-39-6 ]
[ 66644-04-0 ]

Yield	Reaction Conditions	Operation in experiment
	With thionyl chloride for 0.0666667h; Microwave irradiation;

Reference： [1]Location in patent: experimental part Mei, Qinggang; Yang, Jie; Peng, Yongle; Zhao, Zhigang [Journal of Chemical Research, 2011, vol. 35, # 7, p. 386 - 389]

49
[ 102-39-6 ]
[ 1343495-27-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 5 steps 1: thionyl chloride / 0.07 h / Microwave irradiation 2: hydrazine hydrate / 0.05 h / Microwave irradiation 3: potassium hydroxide / ethanol / 14 h / 0 - 20 °C 4: hydrazine hydrate / 0.08 h / Microwave irradiation 5: trichlorophosphate / 0.17 h / Microwave irradiation