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Chemical Structure| 1023272-73-2 Chemical Structure| 1023272-73-2

Structure of 1023272-73-2

Chemical Structure| 1023272-73-2

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Product Details of [ 1023272-73-2 ]

CAS No. :1023272-73-2
Formula : C9H14N2O3
M.W : 198.22
SMILES Code : O=C(C1=C(OCC(C)C)N(C)N=C1)O

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Application In Synthesis of [ 1023272-73-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1023272-73-2 ]

[ 1023272-73-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1023272-73-2 ]
  • [ 62058-03-1 ]
  • C19H29N3O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20℃; for 14h; Example 8; [Show Image] To a dimethylformamide solution (DMF) (5 ml) of a compound V-1 (150 mg) were added monohydroxy-2-adamantamine (140 mg), 1-hydroxybenzotriazole (HOBT) (31 mg), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (WSC) (174 mg), and triethylamine (TEA) (180 mul) under the nitrogen atmosphere, and the mixture was stirred at room temperature for 14 hours. After completion of the reaction, 2N hydrochloric acid (30 ml) was added thereto followed by extraction with ethyl acetate. The organic layer was washed successively with aqueous saturated sodium hydrogen carbonate solution and saturated brine, and dried with magnesium sulfate. A solvent was evaporated, and the residue was purified by silica gel chromatography to obtain a compound VI-1 (226 mg). 1H NMR: (CDCl3); d 1.06 (d, J = 6.6 Hz, 6H), 1.53 - 2.20 (m, 14H), 3.72 (s, 3H), 3.98 (d, J = 6.6 Hz, 2H), 6.25 - 6.30 (m, 1H), 7.71 (s, 1H).(Reference Example 1) The mother washed liquid at filtration obtained in Example 2 was concentrated under reduced pressure, the solvent was evaporated, thereafter, silica gel chromatography (chloroform : methanol = 100 : 0 to 94 : 6) was performed, and fraction solutions corresponding to the formula (III-1'):
 

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