Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | ||||||
{[ item.p_purity ]} | {[ item.pr_size ]} | Inquiry |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price) ]} |
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price) ]} | {[ item.pr_usastock ]} | in stock Inquiry - | {[ item.pr_chinastock ]} | {[ item.pr_remark ]} in stock Inquiry - | Login | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
CAS No. : | 10250-64-3 | MDL No. : | MFCD08271939 |
Formula : | C11H10N2O2 | Boiling Point : | No data available |
Linear Structure Formula : | - | InChI Key : | RTBQZMPYPFQBHA-UHFFFAOYSA-N |
M.W : | 202.21 | Pubchem ID : | 7537625 |
Synonyms : |
|
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
93.1% | With sodium hydroxide In methanol at 20℃; for 2 h; | To a solution of 1-2 (247.5 mg, 1.1 mmol) in MeOH (5 mL) was added sodium hydroxide solution (10 mL, 4 M). The reaction mixture was stirred at room temperature for 2 hours and concentrated under reduced pressure to remove MeOH. The aqueous phase was acidified with aqueous HCl (1 M) till pH=3 and the mixture was extracted with EtOAc, dried with anhydrous Na2SO4, filtered and concentrated to give the crude product. The crude product was purified by silica gel chromatography eluted to give product 1-3 (207.0 mg, 93.1percent). MS m/z [ESI]: 203.1 [M+1]. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | Stage #1: With lithium hydroxide; water In ethanol at 50℃; Stage #2: With hydrogenchloride In water |
Methyl l-methyl-3-phenyl-lH-pyrazole-5-carboxylate (1.0Og, 6.23 iranol) was dissolved in EtOH (10 inL) and water (10 mL) then lithium hydroxide monohydrate (0.582 g, 13.87 mmol) was added. The mixture was stirred at 500C until complete by HPLC. The mixture was concentrated to a residue, water was added and the mixture was extracted with DCM. The aqueous layer was acidified using IN HCl and the resulting solid was filtered and dried under high vacuum to give l-methyl-3-phenyl-lH-pyrazole- 5-carboxylic acid (0.887 g, 95percent) as a white solid; m/z (APCI pos) 203 (100percent) (M+H) . |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
53% | With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In 1,4-dioxane; water at 100℃; for 1 h; Inert atmosphere | Step 3: Synthesis of l-methyl-3-phenyl-lH-pyrazole-5-carboxylic acid 18.3 [00343] Lithio 3 -iodo-1 -methyl- lH-pyrazole-5-carboxyl ate (18.2, 67mg, 0.26 mmol), phenylboronic acid (32mg, 0.26 mmol), K2C03 (76mg, 0.55 mmol) and Pd(PPh3)4 (30mg, 0.026 mmol) were combined in dioxane (HPLC grade, 3 ml) and water (distilled, 3ml) at rt. The mixture was purged with nitrogen for 5 minutes and then heated to 100°C (pre-heated block) with stirring. After lh the reaction was cooled down and filtered over paper washing with dioxane. The crude was loaded on silica for purification by flash column chromatography (heptane/EtOAc 100/0 to 0/100 then EtOAc/MeOH 100/0 to 30/70) to afford 29mg (53percent) of 1- methyl-3 -phenyl- lH-pyrazole-5-carboxylic acid 18.3 as a yellow glassy solid. |
[ 10250-63-2 ]
Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate
Similarity: 0.90
[ 5071-61-4 ]
5-Phenyl-1H-pyrazole-3-carboxylic acid
Similarity: 0.88
[ 1015868-48-0 ]
3-(4-Chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylic acid
Similarity: 0.87
[ 864068-96-2 ]
1-Methyl-3-phenyl-1H-pyrazole-5-carbaldehyde
Similarity: 0.86
[ 192701-73-8 ]
Methyl 3-(p-tolyl)-1H-pyrazole-5-carboxylate
Similarity: 0.81
[ 34252-44-3 ]
2-Methyl-2H-indazole-3-carboxylic acid
Similarity: 0.95
[ 26308-42-9 ]
3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid
Similarity: 0.92
[ 139755-99-0 ]
1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid
Similarity: 0.91
[ 175277-11-9 ]
3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid
Similarity: 0.89
[ 32275-62-0 ]
2-Ethyl-4,5,6,7-tetrahydro-2H-indazole-3-carboxylic acid
Similarity: 0.88
[ 26308-42-9 ]
3-Ethyl-1-methyl-1H-pyrazole-5-carboxylic acid
Similarity: 0.92
[ 139755-99-0 ]
1-Methyl-3-propyl-1H-pyrazole-5-carboxylic acid
Similarity: 0.91
[ 10250-63-2 ]
Ethyl 1-methyl-3-phenyl-1H-pyrazole-5-carboxylate
Similarity: 0.90
[ 175277-11-9 ]
3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid
Similarity: 0.89
[ 5071-61-4 ]
5-Phenyl-1H-pyrazole-3-carboxylic acid
Similarity: 0.88