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[ CAS No. 1025718-91-5 ]

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Chemical Structure| 1025718-91-5
Chemical Structure| 1025718-91-5
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Product Details of [ 1025718-91-5 ]

CAS No. :1025718-91-5 MDL No. :MFCD09027079
Formula : C13H18BNO4 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :263.10 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1025718-91-5 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H332-H335 Packing Group:N/A
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Application In Synthesis of [ 1025718-91-5 ]

  • Downstream synthetic route of [ 1025718-91-5 ]

[ 1025718-91-5 ] Synthesis Path-Downstream   1~16

  • 1
  • [ 29681-44-5 ]
  • [ 73183-34-3 ]
  • [ 1025718-91-5 ]
YieldReaction ConditionsOperation in experiment
100% With potassium acetate In N,N-dimethyl-formamide at 0 - 80℃; for 10h; 24.2 To the solution of 4,4,5,5-tetramethyl- 2-(4,4,5,5-tetramethyl (1,3.2 - dioxaborolan-2-yl)) -1,3,2-dioxaborolane (660mg, 2.60mmol) in DMF (1OmL) at O0C was added KOAc (638g, 6.50mmol) and Pd(dppf)Cl2.CH2Cl2 (53mg, 0.065mmol). The reaction mixture was heated to 8O0C at which point a solution of 24b (468mg, 2.17mmol) in DMF (1 OmL) was added drop- wise. The resulting mixture was stirred at 8O0C for 1 Oh more and evaporated. The residue was chromatographed on silica gel (EA:PE=l :10) to provide 24c (572mg, ca. 100%).
79.4% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In 1,4-dioxane at 89.84℃; for 24h; Inert atmosphere;
66% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere; 1.2 Synthesis of methyl 5-(4, 4,5, 5-tetramethyl-1, 3, 2-dioxaborolan-2-yl)nicotinate To a solution of methyl 5-bromonicotinate (1 g, 4.6 mmol), KOAc (920 mg, 9.2 mmol) and (Bpin)2 (1.7 g, 6.9 mmol) in DMF (10 mE) was added Pd(dppf)C12 under N2, and the resulting reaction mixture was stirred for 4 h at 80°C. After the reaction mixture was concentrated,the residue was dissolved in DCM, then filtered, evaporated and the residue was purified by flash chromatography (PE / EtOAc = 4 / 1) to give the product of methyl 5-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)nicotinate (800 mg, yield: 66%). ‘H-NMR (CDC13, 400 MHz) 9.21 (d, J= 2.4 Hz, 1H), 9.03 (d, J= 2.0 Hz, 1H), 8.61 (t, J= 2.0 Hz, 1H), 3.90 (s, 3H), 1.31 (s, 12H). MS (M+H):264.
66% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere; 1.2 Step 2 - Synthesis of methyl 5-(4, 4,5, 5-tetramet hyl-1 , 3, 2-dioxaborolan-2-yl)nicotinate To a solution of methyl 5-bromonicotinate (1 g, 4.6 mmol), KOAc (920 mg, 9.2 mmol) and (Bpin)2 (1.7 g, 6.9 mmol) in DMF (10 mL) was added Pd(dppf)C12 under N2, and the resulting reaction mixture was stirred for 4 h at 80°C. After the reaction mixture was concentrated, the residue was dissolved in DCM, then filtered, evaporated and the residue was purified by flash chromatography (PE / EtOAc = 4 / 1) to give the product of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinate (800 mg, yield: 66%). ‘H-NMR (CDC13, 400 MHz) 9.21 (d, J= 2.4 Hz, 1H), 9.03 (d, J= 2.0 Hz, 1H), 8.61 (t, J= 2.0 Hz, 1H), 3.90 (s, 3H),1.31 (s, 12H). MS (M+H): 264.
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In dimethyl sulfoxide at 80℃; for 4h; Schlenk technique; Inert atmosphere;
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate

  • 2
  • [ 1025718-91-5 ]
  • [ 1040376-44-0 ]
  • [ 1040377-10-3 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate In water; N,N-dimethyl-formamide at 80℃; 24.3 To the solution of 24c (174mg, 0.66mmol) and D (lOOmg, 0.27mmol) in DMF (1 OmL) was added Pd(Ph3 )2C12 (18mg, 0.026mmol) under the protection of nitrogen, followed by IN Na2CO3 aq. (1.ImL) drop-wise. The reaction mixture was degassed with nitrogen, heated at 8O0C overnight and filtered. The filtrate was evaporated. The residue was dissolved in CH2Cl2/methanol (2:1), dried over Na2SO4, filtered and evaporated to afford crude product 24e which was used directly for the next reaction without further purification.
  • 3
  • [ 1025718-91-5 ]
  • [ 1186111-63-6 ]
  • [ 1186111-70-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 97 Intermediate 97Methyl 6'-(3-ethylureido)-4'-(5-((2-methoxyethylamino)methyl)-4-(trifluoromethyl)thiazol-2- yl)-3,3'-brpyridine-5-carboxylate l-(5-bromo-4-(5-((2-methoxyethylamino)methyl)-4-(trifluoromethyl)thiazol-2-yl)pyridin-2- yl)-3 -ethylurea (Intermediate 90, -500 mg, 1 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2- dioxaborolan-2-yl)nicotinate (0.40 g, 1.5 mmol), and trans dichlorobis(triphenylphosphine)palladium (II) (70 mg, 0.1 mmol) were dissolved in 1,4- dioxane (10 mL). Sodium bicarbonate (252 mg, 3 mmol) was dissolved in water (3 mL) and added to the above mixture. The reaction was heated at 110°C in a microwave for 30 minutes. Ethyl acetate (10 mL) was then added to the reaction and the layers were separated. The solvent was removed in vacuo and the residue was chromatographed on a 12g Analogix column using 0-10% methanol in dichloromethane. The product containing fractions were combined to give the product ester (65% yield). MS (ESP): 539.1 (M+H+) for C23H25F3N6O4S 1H NMR (300 MHz, DMSO-d6): δ 1.11 (t, 3H), 3.21 (m, 2H), 3.23 (s, 3H), 3.37 (m, 4H), 3.89 (s, 3H), 7.49 (t, IH), 8.24 (IH), 8.28 (t, IH), 8.37 (s, IH), 8.74 (d, IH), 9.02 (t, IH), 9.11 (d, IH), 9.52 (bs, IH).
  • 4
  • [ 1025718-91-5 ]
  • [ 1186111-56-7 ]
  • [ 1186111-77-2 ]
  • [ 1186111-78-3 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 104; 105 Intermediate 104 and Intermediate 105 methyl 6'-(3-ethylureido)-4'-(5-(2-methoxyethylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)- 3,3'-bipyridine-5-carboxylate and 6'-(3-ethylureido)-4'-(5-(2-methoxyethylcarbamoyl)-4- (trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylic acid To a 35 mL microwave vial was added sequentially 2-(5-bromo-2-(3-ethylureido)pyridin-4- yl)-N-(2-methoxyethyl)-4-(trifluoromethyl)thiazole-5-carboxamide (Intermediate 83, 0.5 g, 1.0 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)nicotinate (0.40 g, 1.5 mmol), saturated sodium bicarbonate aqueous solution (3 mL), 1,4-dioxane (10 mL), and dichloro-bis(triphenylphosphino) palladium (II) (70 mg, 0.10 mmol). The mixture was then heated at 110 0C in a microwave for 30min. Ethyl acetate (40 mL) and water (40 mL) were added. The aqueous layer was then further extracted with ethyl acetate (2x, 5OmL). The combined organics were dried over sodium sulfate, filtered and concentrated. The residue was loaded on 24g Analogix silica gel column [Heptanes: (9/1) ethyl acetate/methanol] to give ester (Intemediate 105) as off-white powder. The aqueous layer was adjusted to pH ~4 with dilute HCl and extracted with ethyl acetate /tetrahydrofuran (1/1) (3x, 10OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give crude acid Intermediate 106 as yellow solid which was used without further purification.Interemdiate 104: Methyl 6'-(3-ethylureido)-4'-(5-(2-methoxyethylcarbamoyl)-4- (trifluoromethyl) thiazol-2-yl)-3,3'-bipyridine-5-carboxylate MS (ESP): 553.2 (M+H+) for C23H23F3N6O5S1H NMR (300 MHz, DMSO-d6): δ 1.11 (t, 3H), 3.21 (m, 2H), 3.23 (s, 3H), 3.37 (m, 4H), 3.89 (s, 3H), 7.49 (t, IH), 8.24 (IH), 8.28 (t, IH), 8.37 (s, IH), 8.74 (d, IH), 9.02 (t, IH), 9.11 (d, IH), 9.52 (bs, IH).Intermediate 105: 6'-(3-ethylureido)-4'-(5-(2-methoxyethylcarbamoyl)-4- (trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylic acid MS (ESP): 539.1 (M+H+) for C22H21F3N6O5S
  • 5
  • [ 1025718-91-5 ]
  • [ 1186111-57-8 ]
  • [ 1186111-79-4 ]
  • [ 1186111-80-7 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 106; 107 Intermediate 106 and Intermediate 107 methyl 6'-(3 -ethylureido)-4'-(5 -(2-morpholinoethylcarbamoyl)-4-(trifluoromethyl)thiazol-2- yl)-3,3'-bipyridine-5-carboxylate and 6'-(3-ethylureido)-4'-(5-(2-morpholinoethylcarbamoyl)- 4-(trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylic acid To a 35 mL microwave vial was added sequentially 2-(5-bromo-2-(3-ethylureido)pyridin-4- yl)-N-(2-morpholinoethyl)-4-(trifluoromethyl)thiazole-5-carboxamide (Intermediate 84, 0.5 g, 0.9 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)nicotinate (0.36 g, 1.4 mmol), saturated sodium bicarbonate aqueous solution (3 mL), 1,4-dioxane (10 mL), and dichloro-bis(triphenylphosphino) palladium (II) (65 mg, 0.09 mmol). The mixture was then heated to 110 0C in a microwave for 30min. Ethyl acetate (40 mL) and water (40 mL) were added. The aqueous layer was then further extracted with ethyl acetate (2x, 5OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give the crude ester (Intermediate 106) which was used without further purification. The aqueous layer was adjusted to pH ~4 with dilute HCl and extracted with ethyl acetate /tetrahydrofuran (1/1) (3 x, 10OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give crude acid Intermediate 107 as yellow solid which was also used without further purification.Intermediate 106: Methyl 6'-(3-ethylureido)-4'-(5-(2-morpholinoethylcarbamoyl)-4- (trifluoromethyl) thiazol-2-yl)-3,3'-bipyridine-5-carboxylate MS (ESP): 608.1 (M+H+) for C26H28F3N7O5SIntermediate 107: 6'-(3-ethylureido)-4'-(5-(2-morpholinoethylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylic acidMS (ESP): 594.0 (M+H+) for C25H26F3N7O5S
  • 6
  • [ 1025718-91-5 ]
  • [ 1186111-58-9 ]
  • [ 1186111-81-8 ]
  • [ 1186111-82-9 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 108; 109 Intermediate 108 and Intermediate 109 methyl 6'-(3-ethylureido)-4'-(5-(2-(4-methylpiperazin-l-yl)ethylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylate and 6'-(3-ethylureido)-4'-(5-(2-(4- methylpiperazin-l-yl)ethylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5- carboxylic acid To a 35 niL microwave vial was added sequentially 2-(5-bromo-2-(3-ethylureido)pyridin-4- yl)-N-(2-(4-methylpiperazin-l-yl)ethyl)-4-(trifluoromethyl)thiazole-5-carboxamide (Intermediate 85, 0.5 g, 0.9 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)nicotinate (0.36 g, 1.4 mmol), saturated sodium bicarbonate aqueous solution (3 mL), 1,4- dioxane (10 mL), and dichloro-bis(triphenylphosphino) palladium (II) (65 mg, 0.09 mmol). The mixture was then heated to 110 0C in a microwave for 30min. Ethyl acetate (40 mL) and water (40 mL) were added. The aqueous layer was then further extracted with ethyl acetate (2x, 5OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give the crude ester (Intermediate 108) which was used for the next step without further purification. The aqueous layer was then adjusted to pH ~6, 4, and 2 with dilute HCl, and extracted with ethyl acetate /tetrahydrofuran (1/1) however the product remained in the aqueous layer. The aqueous layer was then passed through a 30g Analogix Cl 8 column (acetonitrile/water) to remove most of the salts and give acid Intermediate 109 as yellow solid which was used without further purification.Intermediate 108: Methyl 6'-(3-ethylureido)-4'-(5-(2-(4-methylpiperazin-l- yl)ethylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylate MS (ESP): 621.3 (M+H+) for C27H31F3N8O4SIntermediate 109: 6'-(3-ethylureido)-4'-(5-(2-(4-methylpiperazin-l-yl)ethylcarbamoyl)-4- (trifluoromethyl)thiazol-2-yl)-3,3'-bipyridine-5-carboxylic acid MS (ESP): 607.2 (M+H+) for C26H29F3N8O4S
  • 7
  • [ 1025718-91-5 ]
  • [ 1186111-62-5 ]
  • [ 1186111-83-0 ]
  • [ 1186111-84-1 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 110; 111 Intermediate 110 and Intermediate 111 methyl 4'-(5-(cyclopropylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3-ethylureido)-3,3'- brpyridine-5-carboxylate and 4'-(5-(cvclopropylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3-ethvlureido)-3, S'-bipyridine-S-carboxylic acid To a 35 niL microwave vial was added sequentially 2-(5-bromo-2-(3-ethylureido)pyridin-4- yl)-N-cyclopropyl-4-(trifluoromethyl)thiazole-5-carboxamide (Intermediate 89, 0.5 g, 1.0 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)nicotinate (0.4 g, 1.5 mmol), saturated sodium bicarbonate aqueous solution (3 mL), 1,4-dioxane (10 mL), and dichloro- bis(triphenylphosphino) palladium (II) (70 mg, 0.1 mmol). The mixture was then heated to 110 0C in a microwave for 30min. Ethyl acetate (40 mL) and water (40 mL) were added. The aqueous layer was then further extracted with ethyl acetate (2x, 5OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give the crude ester (Intermediate 110) which was used without further purification. The aqueous layer was adjusted to pH ~4 with dilute HCl and extracted with ethyl acetate /tetrahydrofuran (1/1) (3 x, 10OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give acid Intermediate 111 as yellow solid which was also used without further purification.Intermediate 110: Methyl 4'-(5-(cyclopropylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'- (3-ethylureido)-3,3'-bipyridine-5-carboxylate MS (ESP): 535.2(M+H+) for C23H21F3N6O4SIntermediate 111: 4'-(5-(cyclopropylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3- ethylureido)-3,3'-bipyridine-5-carboxylic acid MS (ESP): 521.1 (M+H+) for C22H19F3N6O4S
  • 8
  • [ 1025718-91-5 ]
  • [ 1186111-61-4 ]
  • [ 1186111-85-2 ]
  • [ 1186111-86-3 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 112; 113 Intermediate 112 and Intermediate 113 methyl 4'-(5-(cyclopentylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3-ethylureido)-3,3'- bipyridine-5-carboxylate and 4'-(5-(cyclopentylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)- 6'-(3-ethylureido)-3,3'-brpyridine-5-carboxylic acid To a 35 niL microwave vial was added sequentially 2-(5-bromo-2-(3-ethylureido)pyridin-4- yl)-N-cyclopentyl-4-(trifluoromethyl)thiazole-5-carboxamide (Intermediate 88, 0.5 g, 1.0 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)nicotinate (0.4 g, 1.5 mmol), saturated sodium bicarbonate aqueous solution (3 mL), 1,4-dioxane (10 mL), and dichloro- bis(triphenylphosphino) palladium (II) (70 mg, 0.1 mmol). The mixture was then heated to 110 0C in a microwave for 30min. Ethyl acetate (40 mL) and water (40 mL) were added. The aqueous layer was then further extracted with ethyl acetate (2x, 5OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give the crude ester (Intermediate 112) which was used without further purification. The aqueous layer was adjusted to pH ~4 with dilute HCl and extracted with ethyl acetate /tetrahydrofuran (1/1) (3 x, 10OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give crude acid Intermediate 113 as yellow solid which was also used without further purification.Intermediate 112: Methyl 4'-(5-(cyclopentylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'- (3-ethylureido)-3,3'-bipyridine-5-carboxylate MS (ESP): 563.1(M+H+) for C25H25F3N6O4SIntermediate 113: 4'-(5-(cyclopentylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3- ethylureido)-3,3'-bipyridine-5-carboxylic acid MS (ESP): 549.0 (M+H+) for C24H23F3N6O4S
  • 9
  • [ 1025718-91-5 ]
  • [ 1186111-60-3 ]
  • [ 1186111-87-4 ]
  • [ 1186111-88-5 ]
YieldReaction ConditionsOperation in experiment
With sodium hydrogencarbonate In 1,4-dioxane; water at 110℃; for 0.5h; Microwave irradiation; 114; 115 Intermediate 114 and Intermediate 115 methyl 4'-(5-(cyclohexylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3-ethylureido)-3,3'- bipyridine-5-carboxylate and 4'-(5-(cyclohexylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'- (3-ethylureido)-3,3'-brpyridine-5-carboxylic acid To a 35 niL microwave vial was added sequentially 2-(5-bromo-2-(3-ethylureido)pyridin-4- yl)-N-cyclohexyl-4-(trifluoromethyl)thiazole-5-carboxamide (Intermediate 87, 0.5 g, 1.0 mmol), methyl 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)nicotinate (0.4 g, 1.5 mmol), saturated sodium bicarbonate aqueous solution (3 mL) 1,4-dioxane (10 mL), and dichloro- bis(triphenylphosphino) palladium (II) (70 mg, 0.1 mmol). The mixture was then heated to 110 0C in a microwave for 30min. Ethyl acetate (40 mL) and water (40 mL) were added. The aqueous layer was then further extracted with ethyl acetate (2x, 5OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give the crude ester (Intermediate 114) which was used without any further purification. The aqueous layer was adjusted to pH ~4 with dilute HCl and extracted with ethyl acetate /tetrahydrofuran (1/1) (3 x, 10OmL). The combined organics were dried over sodium sulfate, filtered, and concentrated to give crude acid Intermediate 115 as yellow solid which was also used without further purification.Intermediate 114: Methyl 4'-(5-(cyclohexylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'- (3-ethylureido)-3,3'-bipyridine-5-carboxylate MS (ESP): 577.1(M+H+) for C26H27F3N6O4SIntermediate 115: 4'-(5-(cyclohexylcarbamoyl)-4-(trifluoromethyl)thiazol-2-yl)-6'-(3- ethylureido)-3,3'-bipyridine-5-carboxylic acid MS (ESP): 563.1 (M+H+) for C25H25F3N6O4S
  • 11
  • [ 1025718-91-5 ]
  • [ 4595-60-2 ]
  • [ 1237518-65-8 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate In 1,2-dimethoxyethane; water for 1.5h; Reflux; Inert atmosphere; 22b Reference Example 22b; 2-Bromopyrimidine (73 mg), sodium carbonate (81 mg), water (0.3 mL), and bis(triphenylphosphine)palladium(II) dichloride (5.3 mg) were added to an ethylene glycol dimethyl ether (1 mL) solution of methyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxylate (0.10 g), followed by heating to reflux under a nitrogen atmosphere for 1 hour and 30 minutes. After cooling the reaction mixture to room temperature, ethyl acetate and water were added thereto, and the insoluble substance was removed by filtration. The organic layer was separated, washed with a saturated aqueous solution of sodium chloride, and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography [Fuji Silysia Chemical Ltd., PSQ100B (spherical), eluent: 90-50% hexane/ethyl acetate] to obtain 30 mg of methyl 5-(pyrimidin-2-yl)pyridine-3-carboxylate as a yellow solid.
  • 12
  • [ 1025718-91-5 ]
  • [ 1237518-66-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 1.5 h / Reflux; Inert atmosphere 2.1: sodium hydroxide; water / 1,4-dioxane; methanol / 1.5 h / 20 °C 2.2: pH 3.8
  • 13
  • [ 887144-97-0 ]
  • [ 1025718-91-5 ]
  • [ 124236-38-0 ]
YieldReaction ConditionsOperation in experiment
With 1,10-Phenanthroline; lithium hydroxide monohydrate; copper(II) thiophene-2-carboxylate In dichloromethane at 45℃; Inert atmosphere; regioselective reaction;
  • 14
  • [ 93-60-7 ]
  • [ 73183-34-3 ]
  • [ 1025718-91-5 ]
YieldReaction ConditionsOperation in experiment
94% Stage #1: bis(pinacol)diborane With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C51H32N8Zn In para-xylene at 20℃; for 0.5h; Schlenk technique; Stage #2: methyl 3-pyridinecarboxylate In para-xylene at 80℃; for 18h; Schlenk technique; regioselective reaction;
With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 4,4'-di-tert-butyl-2,2'-bipyridine In tetrahydrofuran at 80℃; for 24h; Inert atmosphere;
With 2,6-di-tert-butyl-pyridine; (1,5-cyclooctadiene)(methoxy)iridium(I) dimer In tetrahydrofuran at 80℃; for 24h; Glovebox; Inert atmosphere; Sealed tube;
  • 15
  • [ 1025718-91-5 ]
  • [ 1427587-99-2 ]
  • [ 1427588-01-9 ]
YieldReaction ConditionsOperation in experiment
100% With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,4-dioxane at 120℃; for 3h; 32.C [C] 6-(2-Methoxycarbonyl-vinyl)-5-nitro-[2,3]bipyridinyl-5′-carboxylic acid methyl ester 3-(6-Bromo-3-nitro-pyridin-2-yl)-3-(toluene-4-sulfonyl)-propionic acid methyl ester (1.2 g, 2.7 mmol), Pd(PPh3)2Cl2 (190 mg, 0.27 mmol), Na2CO3 (572 mg, 5.4 mmol) and 3-(methoxycarbonyl)pyridine-5-boronic acid pinacol ester (926 mg, 3.5 mmol) were dissolved in 1,4-dioxane (4.0 mL) and the resulting reaction mixture was heated at 120° C. for 3 hours before it was poured into H2O (50 mL). After extraction with EtOAc, the organic layer was washed with brine, dried over anhy. Na2SO4, filtered and concentrated in vacuo to give 6-(2-methoxycarbonyl-vinyl)-5-nitro-[2,3′]bipyridinyl-5′-carboxylic acid methyl ester (926 mg, quant.) as a light yellow solid. MS: 344.1 (M+H+)
100% With sodium carbonate In 1,4-dioxane at 120℃; for 3h; 32.C [C] 6-(2-Methoxycarbonyl-vinyl)-5-nitro-[2,3,]bipyridinyl-5'-carboxylic acid methyl ester [C] 6-(2-Methoxycarbonyl-vinyl)-5-nitro-[2,3,]bipyridinyl-5'-carboxylic acid methyl ester 3-(6-Bromo-3-nitro-pyridin-2-yl)-3-(toluene-4-sulfonyl)-propionic acid methyl ester (1.2 g, 2.7 mmol), Pd(PPh3)2Cl2 (190 mg, 0.27 mmol), Na2C03 (572 mg, 5.4 mmol) and 3- (methoxycarbonyl)pyridine-5-boronic acid pinacol ester (926 mg, 3.5 mmol) were dissolved in 1,4-dioxane (4.0 mL) and the resulting reaction mixture was heated at 120 °C for 3 hours before it was poured into H20 (50 mL). After extraction with EtOAc, the organic layer was washed with brine, dried over anhy. Na2S04, filtered and concentrated in vacuo to give 6-(2-methoxycarbonyl-vinyl)-5-nitro-[2,3']bipyridinyl-5'-carboxylic acid methyl ester (926 mg, quant.) as a light yellow solid. MS: 344.1 (M+H+).
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  • [ 1025718-91-5 ]
  • [ 1427588-03-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium carbonate / 1,4-dioxane / 3 h / 120 °C 2: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 13 h / 50 °C / 2585.81 Torr
Multi-step reaction with 2 steps 1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,4-dioxane / 3 h / 120 °C 2: palladium 10% on activated carbon; hydrogen; acetic acid / methanol / 13 h / 50 °C / 2585.81 Torr
Historical Records

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