1027818-88-7|4-Chloro-5-iodo-2-(trifluoromethyl)pyridine| Ambeed

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Quality Control of [ 1027818-88-7 ] Purity: 95% SDS Specification

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Product Details of [ 1027818-88-7 ]

CAS No. :	1027818-88-7
Formula :	C₆H₂ClF₃IN
M.W :	307.44
SMILES Code :	FC(C1=NC=C(I)C(Cl)=C1)(F)F
MDL No. :	MFCD24369746
InChI Key :	OTNLJEHWSRSJGX-UHFFFAOYSA-N
Pubchem ID :	68756059

Safety of [ 1027818-88-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1027818-88-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1027818-88-7 ]

[ 1027818-88-7 ] Synthesis Path-Downstream 1~1

1
[ 1027818-88-7 ]
[ 1239462-10-2 ]

Yield	Reaction Conditions	Operation in experiment
	With ammonium hydroxide; In dimethyl sulfoxide; at 110.0℃; for 48.0h;	Concentrated aqueous ammonium hydroxide (10 mL) was added to a solution of 4-chloro-5-iodo-2-(trifluoromethyl)pyridine (4.11 g, 13.3 mmol) in DMSO in a glass pressure tube. The tube was sealed and placed in an oil bath pre-heated to 110 0C for 48 h. The resulting solution was diluted with brine, extracted with ethyl acetate, dried (Na2SO4), filtered and concentrated under vacuum to give 5-iodo-2-(trifluoromethyl)pyridin-4-amine. Retention time (min) = 1.584, method [1], MS(ESI) 289.0 (M+H).

References: [1]Patent: WO2010/91310,2010,A1 .Location in patent: Page/Page column 140.

Historical Records

Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Preparation of Amines • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Related Functional Groups of
[ 1027818-88-7 ]

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Related Parent Nucleus of
[ 1027818-88-7 ]

Pyridines

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CAS No.: 1027818-88-7

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