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Chemical Structure| 1028648-22-7 Chemical Structure| 1028648-22-7

Structure of 1028648-22-7

Chemical Structure| 1028648-22-7

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Product Details of [ 1028648-22-7 ]

CAS No. :1028648-22-7
Formula : C24H18BNO2
M.W : 363.22
SMILES Code : OB(C1=CC2=C(C=C1)N(C3=CC=C(C4=CC=CC=C4)C=C3)C5=C2C=CC=C5)O
MDL No. :MFCD22581304
InChI Key :HUSSQXMWKXPRRF-UHFFFAOYSA-N
Pubchem ID :57746267

Safety of [ 1028648-22-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1028648-22-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1028648-22-7 ]

[ 1028648-22-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 160199-05-3 ]
  • [ 1028648-22-7 ]
  • C34H20ClN3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With tetrakis(triphenylphosphine) palladium(0); In 1,4-dioxane; water; at 80℃;Alkaline conditions; In a round bottom flask was added 2,4-dichlorobenzo[4,5]thiophene [3,2-d]pyrimidine (10 g, 39.2 mmol), (9-phenyl-9H-indazol-2-yl)boronic acid (14.2 g, 39.2 mmol), tetrakistriphenylphosphine palladium (1.4 g, 1.2 mmol), sodium hydroxide (3.9 g,98 mmol) and a mixed solvent of tetrahydrofuran (200 mL) and deionized water (100 mL). Heat the reaction system to reflux at 80 Cshould. After the reaction was completed, it was cooled to room temperature, and the reaction liquid was diluted with distilled water. Then extract the reaction solution with dichloromethane and water, with noThe organic phase was dried over magnesium sulfate and concentrated. Purification by silica gel column chromatography, recrystallization to give intermediate I-7 (14.7 g, yield)
  • 2
  • [ 160199-05-3 ]
  • [ 1028648-22-7 ]
  • C34H20ClN3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% With tetrakis(triphenylphosphine) palladium(0); sodium hydroxide; In tetrahydrofuran; water; at 80℃; Intermediate I-3 (10 g, 39.2 mmol), (9-phenyl-9H-indazol-3-yl)boronic acid (14.2 g,39.2 mmol), tetrakistriphenylphosphine palladium (1.4 g, 1.2 mmol), sodium hydroxide (3.9 g, 98 mmol) and tetrahydrofuran (200 mL)Mixed solvent with deionized water (100 mL). The reaction system was heated to reflux at 80 C. After the reaction is completed, it is cooled to room temperature.The reaction solution was diluted with distilled water. The reaction mixture was then extracted with dichloromethane and water.Purification by silica gel chromatography, recrystallization afforded Intermediate I-5 (15.8 g, yield 75%).
 

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