[ CAS No. 10312-55-7 ]

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CAS No. 10312-55-7, is an aryls compound, with a molecular weight of 181.15, molecular formula C8H7NO4, Ambeed provides reports for batches of (such as NMR, HPLC/GC).

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Purity: {[proInfo.showProBatch.pb_purity]}

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Product Details

CAS No. :10312-55-7MDL No. :MFCD00134536
Formula :C8H7NO4InChI Key :GPNNOCMCNFXRAO-UHFFFAOYSA-N
M.W :181.15Pubchem ID :2724822
Boiling Point :-
Synonyms :

Computed Properties

TPSA : 101 H-Bond Acceptor Count : 5
XLogP3 : - H-Bond Donor Count : 3
SP3 : 0.00 Rotatable Bond Count : 2

Safety

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305+P351+P338UN#:N/A
Hazard Statements:H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis

[ 10312-55-7 ] Synthesis Path-Upstream   1~15

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YieldReaction ConditionsOperation in experiment
99% With palladium 10% on activated carbon; ammonium formate; silica gel In methanol for 1.50 h; Milling General procedure: In a typical experiment, a mixture of nitroarene compound (1.0 mmol),ammonium formate (3.3 mmol, 208 mg, 1.1 equivalent), palladium catalyst (10 percent Pdon activated carbon, 2 molpercent, 21 mg) and silica (175 mg) was ball milled in thepresence of dry methanol (η = 0.25 μL mg−1) for 90 minutes. After milling, a smallsample (≈ 1 mg) of the crude reaction mixture was suspended in methanol andimmediately analyzed by TLC (typically using dichloromethane : methanol = 20 : 1mixture as an eluent). The crude mixture was left in a well ventilated hood overnight,suspended in methanol and filtered over a Büchner funnel. Evaporation of the filtrateafforded the desired amino-derivative. If necessary, the final product was purified bycolumn chromatography.
63.3% With hydrogenchloride; tin(ll) chloride In water at 70℃; for 3.00 h; 1 part by weight of the nitro compound of PTA and 3 parts by weight of stannous chloride, 60 parts by weight of concentrated hydrochloric acid having a concentration of 35percent were uniformly mixed and reacted at 70 ° C for 3 hours. After the completion of the reaction, the reaction mixture was cooled to 30 ° C, trueVacuum filtration; filter cake to join the deionized water mixed evenly, and then vacuum filtration, repeat filter cake by adding deionized water mixed vacuum pumpingThe filter cake was dried three times at 70 ° C in vacuo for 3 hours to give the amino compound of PTA.The purity of the amino compound of PTA was 92percent and the yield was 63.3percent.
Reference: [1] Journal of Organic Chemistry, 1988, vol. 53, # 18, p. 4209 - 4218
[2] Molecules, 2018, vol. 23, # 12,
[3] Farmaco, Edizione Scientifica, 1984, vol. 39, # 11, p. 968 - 978
[4] Patent: CN103664684, 2016, B. Location in patent: Paragraph 0039
[5] Chemische Berichte, 1877, vol. 10, p. 145
[6] Journal of medicinal chemistry, 1966, vol. 9, # 1, p. 165 - 168
[7] RSC Advances, 2014, vol. 4, # 87, p. 46476 - 46480
  • 2
  • [ 5372-81-6 ]
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Reference: [1] Journal of Medicinal Chemistry, 1981, vol. 24, # 6, p. 735 - 742
[2] Inorganic Chemistry, 2018, vol. 57, # 3, p. 1040 - 1047
  • 3
  • [ 100-21-0 ]
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Reference: [1] Chemische Berichte, 1877, vol. 10, p. 145
[2] RSC Advances, 2014, vol. 4, # 87, p. 46476 - 46480
[3] Patent: CN103664684, 2016, B
  • 4
  • [ 99185-32-7 ]
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Reference: [1] Journal of the American Chemical Society, 1907, vol. 29, p. 86
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  • [ 2050-44-4 ]
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Reference: [1] Journal of the American Chemical Society, 1907, vol. 29, p. 86
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  • [ 959-26-2 ]
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Reference: [1] RSC Advances, 2014, vol. 4, # 87, p. 46476 - 46480
[2] Patent: CN103664684, 2016, B
  • 7
  • [ 860754-74-1 ]
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Reference: [1] Monatshefte fuer Chemie, 1910, vol. 31, p. 1297
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  • [ 95-63-6 ]
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Reference: [1] Monatshefte fuer Chemie, 1910, vol. 31, p. 1297
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  • [ 54699-35-3 ]
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Reference: [1] Monatshefte fuer Chemie, 1910, vol. 31, p. 1297
  • 10
  • [ 528-44-9 ]
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Reference: [1] Monatshefte fuer Chemie, 1910, vol. 31, p. 1297
  • 11
  • [ 2459-10-1 ]
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Reference: [1] Monatshefte fuer Chemie, 1910, vol. 31, p. 1297
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  • [ 13940-95-9 ]
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Reference: [1] Monatshefte fuer Chemie, 1910, vol. 31, p. 1297
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  • [ 64-17-5 ]
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  • [ 99185-32-7 ]
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Reference: [1] Journal of the American Chemical Society, 1907, vol. 29, p. 86
  • 14
  • [ 52-90-4 ]
  • [ 1391926-97-8 ]
  • [ 31499-93-1 ]
  • [ 1391926-99-0 ]
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Reference: [1] Angewandte Chemie - International Edition, 2012, vol. 51, # 26, p. 6502 - 6505
  • 15
  • [ 89-78-1 ]
  • [ 610-29-7 ]
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Reference: [1] Monatshefte fuer Chemie, 1900, vol. 21, p. 627[2] Monatshefte fuer Chemie, 1902, vol. 23, p. 410
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