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Chemical Structure| 103237-52-1 Chemical Structure| 103237-52-1

Structure of 103237-52-1

Chemical Structure| 103237-52-1

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Product Details of [ 103237-52-1 ]

CAS No. :103237-52-1
Formula : C17H16FN3O4
M.W : 345.33
SMILES Code : O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CC(NCC4)=O)=C3)C1=O)O

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Application In Synthesis of [ 103237-52-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 103237-52-1 ]

[ 103237-52-1 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 5625-67-2 ]
  • [ 93107-30-3 ]
  • [ 103237-52-1 ]
  • 2
  • [ 280-57-9 ]
  • [ 5625-67-2 ]
  • [ 93107-30-3 ]
  • [ 103237-52-1 ]
YieldReaction ConditionsOperation in experiment
In methanol; dimethyl sulfoxide; EXAMPLE 1 STR9 5.3 g (20 mmol) of 1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid are initially introduced into 50 ml of DMSO and heated with 2.4 g (24 mmol) of 2-piperazinone and 4.4 g (40 mmol) of 1,4-diazabicyclo[2.2.2]octane at 130° C. for 1 hour. After cooling, the suspension is adjusted to pH 5 with 2 N hydrochloric acid, 50 ml of water are added, and the precipitate is filtered off with suction, washed with water and methanol, and then boiled in 50 ml of methanol. 5 g (72percent of theory) of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-quinolinecarboxylic acid of melting point 342°-348° C. (decomposition) and purity 97percent (HPLC) are isolated. Mass spectrum: m/e 345 (M+), 301 (94percent, M+--CO2), 231 (M+--C 3 H4 NO), 202, 44 (100percent, CO2). NMR (CF3 COOH)=delta1.45 and 1.7 broad (4H in the cyclopropyl radical), 3.9 and 4.0 broad (5H, N--CH in the cyclopropyl radical, N--CH2 CH2 --N), 4.6 broad (2H, CO--CH2 --N), 7.85 d (1H, on C-8), 8.28 d (1H, on C-5), 9.3 s (1H, on C-2).
 

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