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Chemical Structure| 1035690-30-2 Chemical Structure| 1035690-30-2

Structure of 1035690-30-2

Chemical Structure| 1035690-30-2

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Product Details of [ 1035690-30-2 ]

CAS No. :1035690-30-2
Formula : C10H10ClNO2
M.W : 211.65
SMILES Code : O=C(OC)C1=C(Cl)N=CC(C2CC2)=C1
MDL No. :MFCD22559978

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Application In Synthesis of [ 1035690-30-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1035690-30-2 ]

[ 1035690-30-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1035690-30-2 ]
  • [ 26807-73-8 ]
  • methyl 2-((1-benzyl-1H-indol-5-yl)amino)-5-cyclopropylnicotinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
126 mg With tris-(dibenzylideneacetone)dipalladium(0); tert-butyl 5-amino-1-benzyl-1H-indole-2-carboxylate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In toluene; at 120 - 130℃; for 3.0h;Inert atmosphere; Sealed tube; [Example 36] (0909) (0910) The mixture of 105 mg of <strong>[26807-73-8]1-benzyl-1H-indol-5-amine</strong>, 100 mg of methyl 2-chloro-5-cyclopropylnicotinate, 21.7 mg of tris(dibenzylideneacetone)dipalladium(0), 27.3 mg of 4,5'-bis(diphenylphosphino)-9,9'-dimethylxanthene, 308 mg of cesium carbonate, and 2 mL of toluene, was stirred in a sealed tube at an external temperature of 120 to 130C for three hours under a nitrogen atmosphere. The reaction mixture was cooled to room temperature, and ethyl acetate and water were then added thereto. The organic layer was separated, sequentially washed with water and a saturated aqueous sodium chloride solution and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel column chromatography (gradient elution with hexane: ethyl acetate = 90:10-70:30) to give 126 mg of methyl 2-((1-benzyl-1H-indol-5-yl)amino)-5-cyclopropylnicotinate as a yellow solid. 1H-NMR (CDCl3) delta: 0.58-0.66 (2H, m), 0.87-0.95 (2H, m), 1.75-1.87 (1H, m), 3.92 (3H, s), 5.31 (2H, s), 6.51 (1H, d, J = 3.3 Hz), 7.07-7.14 (3H, m), 7.19-7.33 (5H, m), 7.89 (1H, d, J = 2.0 Hz), 7.91 (1H, d, J = 2.6 Hz), 8.19 (1H, d, J = 2.6 Hz), 9.83 (1H, s).
 

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