Alternatived Products of [ 1036724-55-6 ]
Product Details of [ 1036724-55-6 ]
| CAS No. : | 1036724-55-6 |
MDL No. : | MFCD11520674 |
| Formula : |
C13H10BrFO
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
281.12
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 1036724-55-6 ]
| Signal Word: | |
Class: | |
| Precautionary Statements: | |
UN#: | |
| Hazard Statements: | |
Packing Group: | |
Application In Synthesis of [ 1036724-55-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 1036724-55-6 ]
- 1
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[ 38573-88-5 ]
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[ 100-51-6 ]
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[ 295376-29-3 ]
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[ 1036724-55-6 ]
- 2
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[ 2040-89-3 ]
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[ 100-39-0 ]
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[ 1036724-55-6 ]
| Yield | Reaction Conditions | Operation in experiment |
| 100% |
With potassium carbonate; In acetonitrile; at 150℃; for 0.25h;Microwave irradiation; |
Intermediate 342-Benzyloxy- 1 -bromo-3 -fluoro-benzene (1-34)BrTo a solution of 2-Bromo-6-fluorophenol [C.A.S. 2040-89-3] (1 g, 5.23 mmol) and benzylbromide [C.A.S. 100-39-0] (0.57 mL, 4.76 mmol) in CH3CN (10 mL), K2C03 (0.79 g, 5.71 mmol) was added. The r.m. was heated under microwave irradiation at 150C for 15 min. Then the r.m. was diluted with water and Et20, the organic layer separated, dried (Na2S04), filtered and the solvent evaporated in vacuo. The residue was purified by column chromatography (silica gel, DCM in heptane 0/100 to 20/80) the desired fractions were collected and concentrated in vacuo to yield intermediate 1-34 (1.34 g, quant, yield). |
| 1.34 g |
With potassium carbonate; In acetonitrile; at 150℃; for 0.25h;Microwave irradiation; |
2-Benzyloxy-1-bromo-3-fluoro-benzene (I-34) To a solution of 2-Bromo-6-fluorophenol [C.A.S. 2040-89-3] (1 g, 5.23 mmol) and benzylbromide [C.A.S. 100-39-0] (0.57 mL, 4.76 mmol) in CH3CN (10 mL), K2CO3 (0.79 g, 5.71 mmol) was added. The r.m. was heated under microwave irradiation at 150 C. for 15 min. Then the r.m. was diluted with water and Et2O, the organic layer separated, dried (Na2SO4), filtered and the solvent evaporated in vacuo. The residue was purified by column chromatography (silica gel, DCM in heptane 0/100 to 20/80) the desired fractions were collected and concentrated in vacuo to yield intermediate I-34 (1.34 g, quant. yield). |
- 3
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[ 2040-89-3 ]
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[ 100-44-7 ]
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[ 1036724-55-6 ]
| Yield | Reaction Conditions | Operation in experiment |
| 138 g |
With potassium carbonate; In N,N-dimethyl-formamide; at 60 - 70℃; for 12h; |
95.5 g of <strong>[2040-89-3]2-fluoro-6-bromophenol</strong>, 103 g of potassium carbonate, 300 ml of DMF (N,N-dimethylformamide) were placed in a 1 L back bottle, and the temperature was raised to 60 C.65 g of benzyl chloride was added dropwise, followed by incubation at 60-70 C for 12 hours. Add 600 ml of water to room temperature and extract with 500 ml of toluene.After subsequent washing and dry distillation, 138 g of 3-fluoro-2-benzyloxybromobenzene was obtained. |
- 4
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[ 1036724-55-6 ]
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[ 156487-12-6 ]
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[ 2409057-44-7 ]
| Yield | Reaction Conditions | Operation in experiment |
| 174 g |
With di-tert-butyl[dichloro({di-tert-butyl[4-(dimethylamino)phenyl]phosphaniumyl})palladio][4-(dimethylamino)phenyl]phosphanium; potassium carbonate In ethanol; water for 8h; Inert atmosphere; Reflux; |
1.1
Into a 2 L reaction flask, 138 g of 3-fluoro-2-benzyloxybromobenzene, 126 g of 4-butoxy-2,3-difluorobenzeneboronic acid, 69 g of potassium carbonate, 150 ml of ethanol, and 300 ml of water were charged.Under a nitrogen atmosphere, 0.2 g of the catalyst pd-132 was added, followed by heating under reflux for 8 hours.At room temperature, toluene extraction, after workup to give a yellow liquid (intermediate A-1) 174g; |
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