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Chemical Structure| 1037770-29-8 Chemical Structure| 1037770-29-8

Structure of 1037770-29-8

Chemical Structure| 1037770-29-8

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Product Details of [ 1037770-29-8 ]

CAS No. :1037770-29-8
Formula : C8H8BrN3
M.W : 226.07
SMILES Code : CC1=CNC2=NC(C)=C(Br)N=C21

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Application In Synthesis of [ 1037770-29-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1037770-29-8 ]

[ 1037770-29-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 848841-68-9 ]
  • [ 1037770-29-8 ]
  • [ 1037770-33-4 ]
YieldReaction ConditionsOperation in experiment
With caesium carbonate;palladium diacetate; copper(l) iodide; triphenylphosphine; In N,N-dimethyl-formamide; at 120.0℃; Example 30: Preparation of: 2-(4-Chloro-2-morrhoholin-4-yl-1.2-thiazol-5-yl)-5-(l-cyclorhoropylethv?-3,7-dimethyl-5H-pyitauolo[2.3- j>1pyrazine; Part A: 2-(4-ChioiO-2-morpholiniota-4-yl-1 ,2-thiazol-5-ylV3.7-dimethyl-SH-pvitauolof2.3--?lpyrazine; A Teflon screw-cap vial is charged with crude 2-bromo-3.7-trimethyl-5-H-pyrrolo[3.2-&]pyrazine (800 mg, 2.43 mmol, 1.0 equiv) and DMF (8 mL). To the solution is added <strong>[848841-68-9]4-(4-chlorothiazol-2-yl)morpholine</strong> (498 mg, 2.43 mmol, 1.0 equiv), triphenylphosphine (127 mg, 0.49 mmol, 0.20 equiv), copper(I) iodide (1 16 mg, 0.61 mmol, 0.25 equiv), cesium carbonate (1.59 g, 4.87 mmol, 2.0 equiv), and palladium acetate (27 mg, 0.61 mmol, 0.05 equiv). The reaction vial is evacuated and purged with nitrogen three times before being tightly capped and heated overnight at 120 C. The reaction mixture is cooled to rt, diluted with water and extracted with EtOAc (3 X 10 mL). The combined organic extracts are washed with brine, dried over Na2SO4 and concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography using 30% EtOAc in hexanes to give the desired compound as a yellow solid.
 

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