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Chemical Structure| 1039416-36-8 Chemical Structure| 1039416-36-8

Structure of 1039416-36-8

Chemical Structure| 1039416-36-8

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Product Details of [ 1039416-36-8 ]

CAS No. :1039416-36-8
Formula : C8H7ClN2O
M.W : 182.61
SMILES Code : C2=CC1=NC(=C[N]1C=C2Cl)CO
MDL No. :MFCD11840955

Safety of [ 1039416-36-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 1039416-36-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1039416-36-8 ]

[ 1039416-36-8 ] Synthesis Path-Downstream   1~12

  • 1
  • 6-chloroimidazo[1,2-a]pyridine-2-carboxylic acid [ No CAS ]
  • [ 1039416-36-8 ]
YieldReaction ConditionsOperation in experiment
Step (a) 6-chloroimidazo[l,2-a]pyridine-2-carbaldehyde; 6-Chloro-imidazo[l,2-a]pyridine-2-carboxylic acid (0.4 g, 2 mmol) was dissolved in dry THF (10 ml) and 1.0M borane/THF solution (5 ml, 5 mmol) was added, and the mixture heated at reflux for 2h. Mixture was quenched with methanol (2 ml), acidified with 3 drops of concentrated hydrochloric acid and heated at reflux for 15 min. The mixture was then adsorbed on to SCX resin, washed well with methanol and the crude alcohol intermediate eluted with 10% aqueous ammonia in methanol. This intermediate (0.4 g, 2.2 mmol) was mixed with manganese dioxide (2 g, 23 mmol) in dichloromethane (50 ml) and was heated at reflux for 30 min. The inorganics were removed by filtration and the filtrate evaporated to dryness to afford the sub-title compound (0.32 g, 89%). <n="42"/>1H NMR (300 MHz, CDCl3): delta 10.22 (s, IH), 8.33 (s, IH), 8.09 (s, IH), 7.64 (d, IH), 7.27 (dd, IH)
  • 2
  • [ 1039416-36-8 ]
  • [ 881841-30-1 ]
YieldReaction ConditionsOperation in experiment
With manganese(IV) oxide; In dichloromethane; for 0.5h;Heating / reflux; Step (a) 6-chloroimidazo[l,2-a]pyridine-2-carbaldehyde; 6-Chloro-imidazo[l,2-a]pyridine-2-carboxylic acid (0.4 g, 2 mmol) was dissolved in dry THF (10 ml) and 1.0M borane/THF solution (5 ml, 5 mmol) was added, and the mixture heated at reflux for 2h. Mixture was quenched with methanol (2 ml), acidified with 3 drops of concentrated hydrochloric acid and heated at reflux for 15 min. The mixture was then adsorbed on to SCX resin, washed well with methanol and the crude alcohol intermediate eluted with 10% aqueous ammonia in methanol. This intermediate (0.4 g, 2.2 mmol) was mixed with manganese dioxide (2 g, 23 mmol) in dichloromethane (50 ml) and was heated at reflux for 30 min. The inorganics were removed by filtration and the filtrate evaporated to dryness to afford the sub-title compound (0.32 g, 89%). <n="42"/>1H NMR (300 MHz, CDCl3): delta 10.22 (s, IH), 8.33 (s, IH), 8.09 (s, IH), 7.64 (d, IH), 7.27 (dd, IH)
  • 3
  • [ 1039416-36-8 ]
  • [ 1082738-92-8 ]
  • 4
  • [ 1039416-36-8 ]
  • 6-chloroimidazo[1,2-a]pyridine-2-ylmethyl 2-(4-methylbenzoyl)benzoate [ No CAS ]
YieldReaction ConditionsOperation in experiment
65% The above compound is synthesized according to the procedure described in Scheme 1, using <strong>[1039416-36-8](6-chloroimidazo[1,2-a]pyridin-2-yl)methanol</strong> (RN1039416-36-8; Fluorochem) as an alcohol and 2-(4-methylbenzoyl)benzoic acid (RN85-55-2; Alfa Aesar) as an acid. (Yield: 65%)
  • 5
  • [ 1072-98-6 ]
  • [ 1039416-36-8 ]
  • 6
  • [ 67625-38-1 ]
  • [ 1039416-36-8 ]
  • 7
  • [ 1039416-36-8 ]
  • C17H13BrClN5O [ No CAS ]
  • 8
  • [ 1039416-36-8 ]
  • C27H32ClN5O2Si [ No CAS ]
  • 9
  • [ 1039416-36-8 ]
  • C21H18ClN5O2 [ No CAS ]
  • 10
  • [ 1039416-36-8 ]
  • C21H22ClN5O2 [ No CAS ]
  • 11
  • [ 1039416-36-8 ]
  • C8H6BrClN2O [ No CAS ]
  • 12
  • [ 1039416-36-8 ]
  • C8H5BrCl2N2 [ No CAS ]
 

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