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Chemical Structure| 104-97-2 Chemical Structure| 104-97-2

Structure of Cyclopentanepropionyl chloride
CAS No.: 104-97-2

Chemical Structure| 104-97-2

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Product Details of [ 104-97-2 ]

CAS No. :104-97-2
Formula : C8H13ClO
M.W : 160.64
SMILES Code : O=C(Cl)CCC1CCCC1
MDL No. :MFCD00001391
InChI Key :SZQVEGOXJYTLLB-UHFFFAOYSA-N
Pubchem ID :66039

Safety of [ 104-97-2 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 104-97-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 104-97-2 ]

[ 104-97-2 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 104-97-2 ]
  • [ 137215-27-1 ]
  • CH3OCCHCOC6H3SCOCH2CH2CHC4H8 [ No CAS ]
  • 2
  • [ 104-97-2 ]
  • [ 1152107-25-9 ]
  • 3
  • [ 83-73-8 ]
  • [ 104-97-2 ]
  • C17H17I2NO2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
> 99% With dmap; triethylamine; In dichloromethane; at 20℃; for 1h;Inert atmosphere; General procedure: To a stirring solution of 8-hydroxy-5,7-dihaloquinolines (0.10 mmol), triethylamine (4.0 equivalents, 0.40 mmol), and a catalytic amount of 4-dimethlyaminopyridine in dichloromethane (3 mL) was added an acid chloride reagent (1.2 equivalents) at room temperature. The reaction was allowed to stir for one hour before being quenched with an aqueous solution of saturated sodium bicarbonate. The resulting mixture was then transferred to a separatory funnel and ethyl acetate was added to extract the product. The organic layer was sequentially washed with sodium bicarbonate and brine before being collected.The organic layer was then dried with anhydrous sodium sulfate, filtered, and concentrated in vacuo.The respective haloquinoline ester derivative was purified via flash column chromatography using hexanes:ethyl acetate (99:1 to 80:20) to elute giving quinolines 7-11 and 16-21 (62 to >99% yield; average yield: 89%).
  • 4
  • [ 5319-77-7 ]
  • [ 104-97-2 ]
  • 3-cyclopentyl-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)propanamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
74.5% In dichloromethane; at 20℃; In a 50ml three-vial bottle,<strong>[5319-77-7]5-(methylthio)-1,3,4-thiadiazol-2-amine</strong> (0.02 mol), dichloromethane 10 ml, and 3-cyclohexylpropionyl chloride (0.02 mol) were successively added,Stir at room temperature, TLC point plate tracking reaction (petroleum ether:Ethyl acetate = 1:1). After the raw material spots disappear completely,Stop the reaction, extract with dichloromethane, and wash twice with 150 ml of water.Spin-spin desolvation to give a crude product of 3-cyclopentyl-N-(5-(methylthio)-1,3,4-thiadiazol-2-yl)propanamide,Anhydrous ethanol is recrystallized.
  • 5
  • [ 104-97-2 ]
  • [ 57497-39-9 ]
  • C12H23NO2 [ No CAS ]
 

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