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Chemical Structure| 1041598-53-1 Chemical Structure| 1041598-53-1

Structure of 1041598-53-1

Chemical Structure| 1041598-53-1

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Product Details of [ 1041598-53-1 ]

CAS No. :1041598-53-1
Formula : C7H7FN2O4S
M.W : 234.21
SMILES Code : O=S(C1=CC=C(F)C([N+]([O-])=O)=C1)(NC)=O
MDL No. :MFCD11119647

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Application In Synthesis of [ 1041598-53-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1041598-53-1 ]

[ 1041598-53-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1041598-53-1 ]
  • [ 4045-25-4 ]
  • [ 1351094-54-6 ]
YieldReaction ConditionsOperation in experiment
78% With triethylamine; at 110℃; for 20h;Sealed vessel; b) A/-methyl-4-[4-(methyloxy)-1 -piperidinyl]-3-nitrobenzenesulfonamideTo a solution of 4-fluoro-/V-methyl-3-nitrobenzenesulfonamide (300 mg, 1 .281 mmol) and Et3N (3.84 mmol) was added <strong>[4045-25-4]4-(methyloxy)piperidine hydrochloride</strong> (194 mg, 1.281 mmol). The reaction vessel was sealed and heated at 1 10 C for 20 h. The mixture was concentrated and purified by flash column chromatography (5-80% EtOAc/hexanes) to afford the title compound (227.4, 54%) as a yellow oil. LCMS (ES) m/z 330 (M+H)+; 1H NMR (400 MHz, DMSO-d6) delta ppm 1.51 - 1.61 (m, 2 H) 1.89 - 1.97 (m, 2 H) 2.41 (d, J=4.80 Hz, 3 H) 2.98 - 3.08 (m, 2 H) 3.26 - 3.32 (m, 5 H) 3.40 - 3.48 (m, 1 H) 7.44 (d, J=8.84 Hz, 1 H) 7.49 (d, J=5.05 Hz, 1 H) 7.80 (dd, J=8.84, 2.27 Hz, 1 H) 8.12 (d, J=2.27 Hz, 1 H).
 

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