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CAS No. : | 104777-74-4 | MDL No. : | MFCD13191638 |
Formula : | C7H13NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 127.18 | Pubchem ID : | - |
Synonyms : |
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Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | Stage #1: With triethylamine In methanol; dichloromethane at 23℃; for 16 h; Stage #2: With sodium hydroxide In water |
Compound 26 (2.90 g, 10.2 mmol) was suspended in 6 N HCl (85 ml) and refluxed for 16 h. The product was concentrated and azeotroped three times with isopropanol to give a yellow solid. The solid was dissolved in 1:1 CH2Cl2:MeOH (50 ml) and Et3N (3.08 g, 4.3 ml, 30.5 mmol) and di-t-butyl dicarbonate (3.32 g, 15.2 mmol) were added. The mixture was stirred at 23° C. for 16 h, then concentrated. 0.5 N NaOH (50 ml) was added and the mixture extracted with CH2Cl2. The combined organic extracts were dried (MgSO4), filtered, and concentrated. Purification by silica gel chromatography (eluant: 10percent EtOAc-hexane) gave 1.92 g (8.46 mmol, 83percent) of the product 27A as a colorless oil. MS (ES for M+1): m/e 228 |