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Chemical Structure| 10489-74-4 Chemical Structure| 10489-74-4

Structure of 10489-74-4

Chemical Structure| 10489-74-4

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Product Details of [ 10489-74-4 ]

CAS No. :10489-74-4
Formula : C4H8N2O3
M.W : 132.12
SMILES Code : CCOC(=O)C(N)=NO
MDL No. :MFCD03013442

Safety of [ 10489-74-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H319-H228
Precautionary Statements:P240-P210-P241-P264-P280-P302+P352-P370+P378-P337+P313-P305+P351+P338-P362+P364-P332+P313
Class:4.1
UN#:1325
Packing Group:

Application In Synthesis of [ 10489-74-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 10489-74-4 ]

[ 10489-74-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 10489-74-4 ]
  • [ 75-98-9 ]
  • [ 158154-63-3 ]
YieldReaction ConditionsOperation in experiment
1.8 g With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 100℃; 3.10.2 Preparation of ethyl 5-(tert-butyl)-1,2,4-oxadiazole-3-carboxylate (949-4) To a stirred solution of ethyl 2-(hydroxyamino)-2-iminoacetate (5.0 g, 37.8 mmol) in DMF (60 mL) were added pivalic acid (3.86 g, 37.8 mmol), 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDCI) (7.97 g, 41.58 mmol), HOBt (6.12 g, 45.3 mmol) and DIPEA (19.7 mL, 113.4 mmol). After being stirred at room temperature overnight, the reaction mixture was heated up to 100 C. for hr before cooled down to room temperature and partitioned between EA and H2O. The layers were separated and the aqueous layer was extracted with EA (3*). The combined organic layers were washed with brine and dried over Na2SO4. The solvents were removed and the residue was purified by flash chromatography (silica gel, 10?90% ethyl acetate in petroleum ether) to provide ethyl 5-(tert-butyl)-1,2,4-oxadiazole-3-carboxylate (949-4) (1.8 g, 24%) as a yellow solid. LC-MS: ESI m/z (M+1)=199.36.
 

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