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Chemical Structure| 1050602-61-3 Chemical Structure| 1050602-61-3

Structure of 1050602-61-3

Chemical Structure| 1050602-61-3

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Product Details of [ 1050602-61-3 ]

CAS No. :1050602-61-3
Formula : C8H7ClF3N3
M.W : 237.61
SMILES Code : FC(C1=CN=C(Cl)N=C1NC2CC2)(F)F
MDL No. :MFCD27939702

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Application In Synthesis of [ 1050602-61-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1050602-61-3 ]

[ 1050602-61-3 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 3325-11-9 ]
  • [ 1050602-61-3 ]
  • N2-(1H-benzo[d][1,2,3]triazol-6-yl)-N4-cyclopropyl-5-(trifluoromethyl)pyrimidine-2,4-diamine [ No CAS ]
YieldReaction ConditionsOperation in experiment
97 mg With acetic acid; at 110℃; for 0.166667h;Microwave irradiation; Example 188: Preparation of N2-(lH-benzo[d][l,2,3]triazoI-6-yI)-N4-cycIopropyI-5- (trifluoromethyl)pyrimidine-2,4-diamine2-chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine (0.090 g, 0.379 mmol) and l H-benzo[d] [l ,2,3]triazol-5-amine (0.051 g, 0.379 mmol) were mixed in Acetic Acid (2 ml). The mixture was microwaved at 110 °C for 10 minutes and then concentrated. Added acetone and filtered the white solid to give 97 mg of N2-(lH-benzo[d][l ,2,3]triazol-6-yl)-N4-cyclopropyl-5- (trifluoromethyl)pyrimidine-2,4-diamine. MS calcd for [Ci4Hi2F3N7+H]+: 336.12, found 336.20.
  • 2
  • [ 20876-36-2 ]
  • [ 1050602-61-3 ]
  • 5-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)indolin-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
18 mg With acetic acid; at 110℃; for 0.166667h;Microwave irradiation; xample 240: Preparation of 5-((4-(cyclopropylamino)-5-(trifluoromethyI)pyrimidin-2- yl)amino)indolin-2-one 2-Chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine (0.060 g, 0.253 mmol) and <strong>[20876-36-2]5-aminoindolin-2-one</strong> (0.037 g, 0.253 mmol) were mixed in acetic acid (1 ml). The mixture was microwaved at 1 10 °C for 1 0 min. Filtered the solid and washed with acetonitrile to give 18 mg of product. MS calcd for [Ci6H]4F3N50+H]+: 350.13, found 350.10.
  • 3
  • [ 3682-14-2 ]
  • [ 1050602-61-3 ]
  • 6-((4-(cyclopropylamino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-2,3-dihydrophthalazine-1,4-dione [ No CAS ]
YieldReaction ConditionsOperation in experiment
35 mg With acetic acid; at 110℃; for 0.333333h;Microwave irradiation; Example 334: Preparation of 6-((4-(cyclopropyIamino)-5-(trifluoromethyl)pyrimidin-2- yl)amino)-2,3-dihydrophthalazine-l,4-dione2-Chloro-N-cyclopropyl-5-(trifluoromethyl)pyrimidin-4-amine (0.055 g, 0.231 mmol) and 6-amino-2,3-dihydrophthalazine-1 ,4-dione (0.041 g, 0.231 mmol) were mixed in acetic acid (2 ml). The mixture was microwaved at 1 10 °C for 20 min and then concentrated. Added MeOH and 5percent DMF and filtered the solid to give 35 mg of product. MS calcd for [Ci6H13F3N602+H]+: 379.12, found 379.00.
 

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