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Chemical Structure| 1051316-29-0 Chemical Structure| 1051316-29-0

Structure of 1051316-29-0

Chemical Structure| 1051316-29-0

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Product Details of [ 1051316-29-0 ]

CAS No. :1051316-29-0
Formula : C11H10ClNO
M.W : 207.66
SMILES Code : COC1=CC2=CC(CCl)=CC=C2N=C1

Safety of [ 1051316-29-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 1051316-29-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1051316-29-0 ]

[ 1051316-29-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 13472-79-2 ]
  • [ 1051316-29-0 ]
  • [ 1051316-30-3 ]
YieldReaction ConditionsOperation in experiment
Example 128; l-((3-methoxyquinolin-6-yl)methyl)-5-(4-methylthiophen-2-yl)pyridin-2(lH)- one(1) 5-Iodo-l-((3-methoxyquinolin-6-yl)methyl)pyridin-2(lH)-one. To a solution of 6-(chloromethyl)-3-methoxyquinoline (0.042 g, 0.20 mmol) in DMF (8 mL) in a flame dried 25 mL round bottom flask at 0 C was added sodium hydroxide (0.011 g, 0.26 mmol). After stirred for 30 min, <strong>[13472-79-2]5-iodopyridin-2-ol</strong> (0.058 g, 0.26 mmol) was added. The ice bath was removed and the reaction mixture was stirred at rt under N2 for 20 h. The reaction was quenched with water and the resulting mixture was partitioned between EtOAc/sat. NaHCO3. The aqueous layer was extracted with EtOAc (2 x 10 mL). The combined organic <n="177"/>layers were washed with water, brine, dried over MgSO4 and concentrated. The crude product was purified using SiO2 chromatography (Teledyne Isco RediSep, P/N 68-2203-026, 12 g SiO2, isocratic 3% MeOH in DCM with 17% EtOAc, Flow = 30 mL/min). A peak at 15 min was collected. The solvent was removed in vacuo to afford the desired product as white solid (42.0 mg). MS (ESI pos. ion) m/z (M+l): 393.4. Calc'd exact mass for Ci6H13IN2O2: 392.19. 1H NMR (300 MHz, CHLOROFORM-d) delta ppm 3.95 (s, 3 H) 5.26 (s, 2 H) 6.48 (d, J=9.65 Hz, 1 H) 7.37 (d, J=2.78 Hz, 1 H) 7.41 - 7.51 (m, 2 H) 7.54 (d, J=2.19 Hz, 1 H) 7.65 (s, 1 H) 8.04 (d, J=8.48 Hz, 1 H) 8.68 (d, J=2.92 Hz, 1 H).
 

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