Home Cart Sign in  
Chemical Structure| 105252-95-7 Chemical Structure| 105252-95-7

Structure of 105252-95-7

Chemical Structure| 105252-95-7

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 105252-95-7 ]

CAS No. :105252-95-7
Formula : C5H3F3N2
M.W : 148.09
SMILES Code : NC1=C(F)C(F)=NC=C1F
MDL No. :MFCD01862081

Safety of [ 105252-95-7 ]

Application In Synthesis of [ 105252-95-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 105252-95-7 ]

[ 105252-95-7 ] Synthesis Path-Downstream   1~1

  • 1
  • cupric sulfate [ No CAS ]
  • [ 105252-95-7 ]
  • [ 159783-22-9 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; In ethanol; water; REFERENCE EXAMPLE 74 A solution of 4-amino-2,3,5-trifluoropyridine [23.1 g; that is prepared as described in J.Med.Chem.30, 340-347,(1987)] and hydrazine hydrate (113 ML) in ethanol (925 ML) is stirred and heated at 100C for 2 days. The solution is then evaporated to low volume and the resulting 4-amino-3,5-difluoro-2-hydrazinopyridine (22.5 g) is filtered off in the form of a cream solid. This damp solid is added portionwise to a stirred solution of cupric sulfate (132 g) in water (462 ML) below 25C, and the reaction mixture is stirred at room temperature for 48 hours. The reaction mixture is basified by treatment with aqueous potassium hydroxide solution (2 N) and extracted with dichloromethane (1500 ML). The organic layer is filtered through diatomaceous earth, dried over magnesium sulpate, and concentrated to give an off-white solid (13.72 g). This solid is subjected to mplc, using diethyl ether as eluent, to give 4-amino-3,5-difluoropyridine (3.4 g), m.p. 99-101C. [NMR (CDCl3): 4.32(bs,2H),8.1(s,2H)].
 

Historical Records

Technical Information

Categories