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Chemical Structure| 105316-99-2 Chemical Structure| 105316-99-2

Structure of 105316-99-2

Chemical Structure| 105316-99-2

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Product Details of [ 105316-99-2 ]

CAS No. :105316-99-2
Formula : C11H9N3OS
M.W : 231.27
SMILES Code : O=C1NC2=C(C=C(C3=CSC(N)=N3)C=C2)C1
MDL No. :MFCD06385034

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Application In Synthesis of [ 105316-99-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 105316-99-2 ]

[ 105316-99-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 53137-27-2 ]
  • [ 105316-99-2 ]
  • 2,4-dimethyl-N-(4-(2-oxoindolin-5-yl)thiazol-2-yl)thiazole-5-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
58% With pyridine; propylphosphonic anhydride; In ethyl acetate; acetonitrile; at 48.5℃; for 96h;Sealed tube; To a suspension of 5-(2-aminothiazol-4-yl)indolin-2-one (0.050 g, 0.203 mmol) and <strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> (0.035 g, 0.224 mmol), and pyridine (0.06 mL, 0.713 mmol) in acetonitrile (2 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.29 mL, 0.489 mmol). The sealed tube was heated to 48.5 C. for 4 days and the precipitation formed. After cooling, the solid was collected by filtration and washed with cold dichloromethane to give 2,4-dimethyl-N-(4-(2-oxoindolin-5-yl)thiazol-2-yl)thiazole-5-carboxamide (0.045 g, 58%) as a beige solid. 1H NMR (400 MHz, DMSO-d): delta 12.53 (bs 1H), 10.48 (s, 1H), 7.77 (m, 2H), 7.48 (s, 1H), 6.86 (d, 1H, J=8.8 Hz), 3.54 (s, 2H), 2.67 (s, 3H), 2.61 (s, 3H). MS (ESI): Calcd. for C17H14N4O2S2: 370, found 371 (M+1)+.
 

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