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Chemical Structure| 106745-67-9 Chemical Structure| 106745-67-9

Structure of 106745-67-9

Chemical Structure| 106745-67-9

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Product Details of [ 106745-67-9 ]

CAS No. :106745-67-9
Formula : C16H17NO2S
M.W : 287.38
SMILES Code : O=S(C1=CC=C(C)C=C1)(NC2=CC=CC=C2C(C)=C)=O

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Application In Synthesis of [ 106745-67-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106745-67-9 ]

[ 106745-67-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 52562-19-3 ]
  • [ 98-59-9 ]
  • [ 106745-67-9 ]
YieldReaction ConditionsOperation in experiment
With pyridine; In dichloromethane; at 20℃; for 24h; General procedure: The aniline (0.5 g, 3.75 mmol, 1 equiv) was dissolved in dry CH2Cl2 (7.5 mL, 0.5 M), and thesolution was treated with sulfonyl chloride (0.79 g, 4.13 mmol, 1.1 equiv) and pyridine (0.91mL, 11.3 mmol, 3 equiv). The mixture was stirred at room temperature for 24 h, diluted withH2O (25 mL) and extracted with CH2Cl2 (3 x 25 mL). The combined organic layers were washedwith 1M HCl, brine, dried over Na2SO4, and concentrated in vacuo. Flash chromatography of theresulting crude mixture on SiO2 (0-30% EtOAc in hexanes gradient) afforded the sulfonamidesin good yields. Substrate 1b was synthesized according to the above procedure using <strong>[52562-19-3]2-isopropenylaniline</strong> and 2-(trimethylsilyl)ethanesulfonyl chloride. Sulfonamide 1b was obtained
 

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