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Chemical Structure| 106782-78-9 Chemical Structure| 106782-78-9

Structure of 106782-78-9

Chemical Structure| 106782-78-9

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Product Details of [ 106782-78-9 ]

CAS No. :106782-78-9
Formula : C8H10N2O2
M.W : 166.18
SMILES Code : O=C(N)C1=CC=CC(OC)=C1N
MDL No. :MFCD09753573

Safety of [ 106782-78-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 106782-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 106782-78-9 ]

[ 106782-78-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 42926-52-3 ]
  • [ 106782-78-9 ]
  • [ 150479-56-4 ]
YieldReaction ConditionsOperation in experiment
54% In pyridine; dichloromethane; Preparation 3 2-(Ethoxybenzamido)-3-methoxybenzamide 2-Ethoxybenzoyl chloride (8.9 g, 0.048 mol) was added dropwise to a stirred solution of 2-amino-3-methoxybenzamide (4.0 g, 0.024 mol) in pyridine (35 ml) under a nitrogen atmosphere at 0 C. After 20 hours at room temperature, the solvent was removed by evaporation under vacuum, the residue dissolved in dichloromethane (100 ml) and the solution washed successively with 2N hydrochloric acid (2*100 ml) and saturated aqueous sodium hydrogen carbonate solution (2*100 ml). The organic phase was dried (MgSO4) and evaporated under vacuum, then the resulting oil chromatographed on silica gel (40 g), eluding with a mixture of methanol in-dichloromethane (2%), to give the title compound as a colourless solid (4.1 g, 54%), m.p. 177-179 C.
  • 2
  • [ 1039948-89-4 ]
  • [ 106782-78-9 ]
  • [ 1246250-64-5 ]
YieldReaction ConditionsOperation in experiment
With toluene-4-sulfonic acid; sodium hydrogensulfite; In N,N-dimethyl acetamide; at 115℃; for 16.0h; Preparation of 2-(3,5-Dimethyl-4-(2-(pyrrolidin-yl)ethoxy)phenyl)-8-methoxyquinazolin-4(3H)-oneTo a solution of 2-amino-3-methoxy-benzamide (700 mg,4.22 mmol) and 4-(2-hydroxyethoxy)-3,5-dimethyl benzaldehyde (823 mg, 4.22 mmol) in N,N-dimethyl acetamide (10 mE) were added NaHSO3 (58.5 wt %, 841 mg, 4.64 mmol) and p-TSA (160 mg, 0.84 mmol). The reaction mixture was heated at 115 C. for 16 hours, then cooled to room temperature. Solvent was removed under reduced pressure. Water (100 mE) was added and stirred for 1 hour at room temperature. The solid separated was filtered and dried. The solid wasfurther washed with diethyl ether to give crude product 2-[4- (2-hydroxy-ethoxy)-3,5-dimethyl-phenyl] -8-methoxy-3H- quinazolin-4-one as an off-white solid. Yield: 1.2 g (84%).
 

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