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Chemical Structure| 107165-83-3 Chemical Structure| 107165-83-3

Structure of 107165-83-3

Chemical Structure| 107165-83-3

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Product Details of [ 107165-83-3 ]

CAS No. :107165-83-3
Formula : C12H13ClN2O
M.W : 236.70
SMILES Code : ClC1=CC=C(C(C=C2NCCCN2)=O)C=C1
MDL No. :MFCD09266995

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Application In Synthesis of [ 107165-83-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 107165-83-3 ]

[ 107165-83-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4139-61-1 ]
  • [ 107165-83-3 ]
  • [ 122-51-0 ]
  • [ 1634693-27-8 ]
YieldReaction ConditionsOperation in experiment
89% In neat (no solvent); at 50℃; for 0.166667h;Green chemistry; General procedure: HKA 1-3 (0.5 mmol), triethoxymethane 4 (1.0 mmol) and 4-hydroxycoumarin derivatives 5 (0.6 mmol) were charged into a 25 mL round-bottom flask and the mixture was heated to 50 C for about 10 minutes and monitored by TLC. Until the substrate HKA had been used up. Then reaction mixture was cooled to room temperature, filtered and washed with 95% EtOH to give the pure product in 83-95% yield. The products were further identified by FTIR, NMR and HRMS, and were in good agreemen twith the assigned structures.
  • 2
  • [ 107165-83-3 ]
  • [ 146137-78-2 ]
  • 5-(4-chlorobenzoyl)-8-(trifluoromethyl)-1H,2H,3H-pyrimido[1,2-a]quinoline [ No CAS ]
YieldReaction ConditionsOperation in experiment
96% With piperidine; calcium chloride; In 1,4-dioxane; at 75℃; for 6h; A solution of 1- (4-chlorophenyl) -2- (tetrahydropyrimidin-2 (1H) -ylidene) ethan-1-one (1 mmol) and 2-fluoro-5- (Trifluoromethyl) benzaldehyde (2 mmol)A solution of 1,4-dioxane (15 ml) was added as a solvent,The catalyst piperidine (0.5 mmol) was added,And anhydrous calcium chloride (0.5 mmol) were heated to 75 C under magnetic stirring,The reaction was carried out for 6 hours.After filtration, the precipitate was washed with a mixed solvent of a small amount of petroleum ether / chloroform = 10: 2,After which the precipitate was dissolved in methylene chloride,The organic layer was washed successively with a saturated aqueous solution of sodium bicarbonate and a saturated aqueous solution of sodium chloride.After which the chloroform was collected and dried over anhydrous sodium sulfate,Part of the solvent evaporated after adding the appropriate amount of cyclohexane to a precipitate generated,(3-chlorobenzoyl) -8- (trifluoromethyl) -2,3-dihydro-1H-pyrimido [1,2-a] quinoline (Compound 3),Yield 96%.
 

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