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Chemical Structure| 1083326-73-1 Chemical Structure| 1083326-73-1

Structure of 1083326-73-1

Chemical Structure| 1083326-73-1

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Product Details of [ 1083326-73-1 ]

CAS No. :1083326-73-1
Formula : C18H21BF2N2O5S
M.W : 426.24
SMILES Code : O=S(C1=CC=C(F)C=C1F)(NC2=CC(B3OC(C)(C)C(C)(C)O3)=CN=C2OC)=O
MDL No. :MFCD12923393
InChI Key :CTHJPTSKLMLUCQ-UHFFFAOYSA-N
Pubchem ID :59564705

Safety of [ 1083326-73-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 1083326-73-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1083326-73-1 ]

[ 1083326-73-1 ] Synthesis Path-Downstream   1~3

  • 2
  • [ 1060812-84-1 ]
  • [ 1083326-73-1 ]
  • [ 1621718-79-3 ]
YieldReaction ConditionsOperation in experiment
73% With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; water; at 90℃;Inert atmosphere; mixture of <strong>[1060812-84-1]5-bromopyrazolo[1,5-a]pyridine</strong> (197 mg, 1 mmol), 2,4-difluoro-N-(2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzene sulfonamide (639 mg, 1.5 mmol), Na2CO3 (318 mg, 3.0 mmol) and Pd(PPh3)2Cl2 (35 mg, 0.05 mmol) in 1,4-dioxane/H2O (5 mL/1 mL) was stirred at 90° C. under nitrogen atmosphere, and the reaction was monitored by TLC. After completion, the reaction mixture was cooled to room temperature and extracted with diethyl ether (10 mL). The organic phase was washed with brine (10 mL×2), dried with anhydrous sodium sulfate, and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v)=30/1) to give the title compound as a white solid (303 mg, 73percent). MS (ESI, pos. ion) m/z: 416.9 [M+H]+.
  • 3
  • [ 874792-20-8 ]
  • [ 1083326-73-1 ]
  • 2,4-difluoro-N-(2-methoxy-5-(4-methoxyquinolin-6-yl)pyridin-3-yl)benzenesulfonamide [ No CAS ]
 

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Related Functional Groups of
[ 1083326-73-1 ]

Organoborons

Chemical Structure| 1083326-75-3

A106539 [1083326-75-3]

N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide

Similarity: 0.82

Ethers

Chemical Structure| 1083326-75-3

A106539 [1083326-75-3]

N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide

Similarity: 0.82

Amines

Chemical Structure| 1083326-75-3

A106539 [1083326-75-3]

N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide

Similarity: 0.82

Sulfamides

Chemical Structure| 1083326-75-3

A106539 [1083326-75-3]

N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide

Similarity: 0.82

Related Parent Nucleus of
[ 1083326-73-1 ]

Pyridines

Chemical Structure| 1083326-75-3

A106539 [1083326-75-3]

N-(2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)methanesulfonamide

Similarity: 0.82