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Chemical Structure| 1087798-38-6 Chemical Structure| 1087798-38-6

Structure of 1087798-38-6

Chemical Structure| 1087798-38-6

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Product Details of [ 1087798-38-6 ]

CAS No. :1087798-38-6
Formula : C13H21NO4
M.W : 255.31
SMILES Code : CC(C)(C)OC(=O)NC1CC2(C1)CC(C2)C(O)=O
MDL No. :MFCD11099888
InChI Key :QFGQEEVKWSGRQJ-UHFFFAOYSA-N
Pubchem ID :39871602

Safety of [ 1087798-38-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 1087798-38-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1087798-38-6 ]

[ 1087798-38-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3325-11-9 ]
  • [ 1087798-38-6 ]
  • C19H25N5O3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 16h;Inert atmosphere; A solution of the carboxylic acid (starting material 1, 1 mmol), the amine (starting material 2, 1 mmol), 1 -hydro xybenzotriazole hydrate (1.3 mmol) and l-(3-dimethylaminopropyl)-3- ethylcarbodiimide hydrochloride (1.1 mmol) in N,N-dimethylformamide (6 mL) was stirred at room temperature for 16 hours and was then partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered and evaporated in vacuo. The residue was taken up in toluene, concentrated in vacuo, and chromato graphed on silica gel, using a dichloromethane - methanol gradient, producing the amide intermediate as an off-white foam.
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20℃; for 16h; General procedure: A solution of the carboxylic acid (starting material 1, 1 mmol), the amine (starting material 2, 1 mmol), 1-hydroxybenzotriazole hydrate (1.3 mmol) and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (1.1 mmol) in N,N-dimethylformamide (6 mL) was stirred at room temperature for 16 hours and was then partitioned between water and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered and evaporated in vacuo. The residue was taken up in toluene, concentrated in vacuo, and chromatographed on silica gel, using a dichloromethane-methanol gradient, producing the amide intermediate as an off-white foam.
 

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