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Chemical Structure| 1099597-75-7 Chemical Structure| 1099597-75-7

Structure of 1099597-75-7

Chemical Structure| 1099597-75-7

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Product Details of [ 1099597-75-7 ]

CAS No. :1099597-75-7
Formula : C7H2Cl2F3NO
M.W : 244.00
SMILES Code : O=C(Cl)C1=CC(C(F)(F)F)=CN=C1Cl
MDL No. :MFCD11226642

Safety of [ 1099597-75-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H314-H331
Precautionary Statements:P261-P280-P301+P310-P305+P351+P338-P310
Class:8(6.1)
UN#:2922
Packing Group:

Application In Synthesis of [ 1099597-75-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1099597-75-7 ]

[ 1099597-75-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 1099597-75-7 ]
  • [ 35216-39-8 ]
  • 2-chloro-N-(3-methylsulfonylphenyl)-5-(trifluoromethyl)pyridine-3-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
45.1% With N-ethyl-N,N-diisopropylamine; In chloroform; at 20℃; for 24h; A mixture of 2-chloro-5-(trifluoromethyl)pyridine-3-carbonyl chloride (250 mg, 1.02 mmol), 3-methylsulfonylaniline (193 mg, 1.13 mmol) and DIPEA (446 pL, 2.56 mmol) in chloroform (5 mL) was stirred at room temperature for 24 h. The contents were treated with 10% Na2CC>3, extracted with CHCb (3x) and the solvent removed in vacuo to give a yellow foam, which was triturated with MeOH/2% Na2C03 (1: 10). The solid was collected by filtration, washed with water and dried under vacuum to give 2-chloro-N-(3-methylsulfonylphenyl)-5- (trifluoromethyl)pyridine-3-carboxamide (175 mg, 0.462 mmol, 45.1 % yield) as a beige solid. MS, ES+ m/z 379.0 [M+H]+. Tf-NMR (400 MHz, DMSO-rie) d 11.17 (s, 1 H), 9.04 (s, 1 H), 8.72 (d, J=2.27 Hz, 1 H), 8.35 (s, 1 H), 7.94 (d, J=7.83 Hz, 1 H), 7.67 - 7.76 (m, 2 H), 3.25 (s, 3 H).
  • 2
  • [ 1099597-75-7 ]
  • [ 35216-39-8 ]
  • 2-(2,6-dimethylphenoxy)-N-(3-methylsulfonylphenyl)-5-(trifluoromethyl)pyridine-3-carboxamide [ No CAS ]
 

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