Alternatived Products of [ 110821-07-3 ]
Product Details of [ 110821-07-3 ]
CAS No. : | 110821-07-3 |
MDL No. : | MFCD03232921 |
Formula : |
C7H8N2O4
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
184.15
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 110821-07-3 ]
Application In Synthesis of [ 110821-07-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 110821-07-3 ]
- Downstream synthetic route of [ 110821-07-3 ]
- 1
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[ 110821-07-3 ]
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[ 23945-44-0 ]
- 2
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[ 52606-02-7 ]
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[ 110821-07-3 ]
Yield | Reaction Conditions | Operation in experiment |
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With sodium chlorite; sodium dihydrogenphosphate; water; In tert-butyl alcohol; at 0 - 25℃; |
To a solution of 2,4-Bis(methyloxy)-5-pyrimidinecarbaldehyde ( commercially available from Toronto, 1.400 g, 8.33 mmol) at 0 0C in f-Butanol (14.00 mL) an aqueous solution(7 mL) of Sodium chlorite (1.807 g, 19.98 mmol) was added over 25 min and sodium <n="60"/>dihydrogen phosphate hydrate (3.64 g, 23.33 mmol). The yellow mixture obtained was warmed to 25 0C and after 6h 14 ml. of f-Butanol, 7 ml. of water, and Sodium chlorite(2.26 g, 25 mmol) were added. The reaction mixture was stirred at room temperature overnight. After 24 h ,the mixture was evaporated in vacuo, and the crude material purified by SPE 25 g cartridge eluting with DCIWMeOH 8:2 to recover 1 g of title compound.MS (ES) (mlz): 185.2 [M+H]+. |
- 3
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[ 67-56-1 ]
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[ 110821-07-3 ]
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[ 15400-58-5 ]
Yield | Reaction Conditions | Operation in experiment |
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To a suspension of 2,4-Bis(methyloxy)-5-pyrimidinecarboxylic acid (Prep31 , 1.000 g, 5.43 mmol) in N,N-Dimethylformamide (DMF) (35 ml.) at 0 0C N,N'-Carbonyldiimidazole (1.321 g, 8.15 mmol) was added and the mixture was stirred for 1 hour at 0 0C, then left stirring at rt. After 4 h Triethylamine (2.271 ml_, 16.29 mmol) and N,N'-Carbonyldiimidazole (1.321 g, 8.15 mmol), were added to the white suspension. After other 4 h, N, N'- Carbonyldiimidazole (1.321 g, 8.15 mmol) of another batch was added to the suspension. The reaction was left overnight at rt. The solution was then concentrated in vacuo and methanol was added. The solution was stirred at reflux for 2 h. Then the mixture was evaporated in vacuo, the residue was dissolved in DCM and washed with NaHCC>3 sat. sol. and then with H2O. Organic phase was dried with Na2SO4 anhydrous, filtered and evaporated in vacuo to obtain 550 mg of the title compound, which was used in the following step whitout further purification. MS (ES) {mlz): 199.2 [M+H]+. |