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Chemical Structure| 110821-07-3 Chemical Structure| 110821-07-3

Structure of 110821-07-3

Chemical Structure| 110821-07-3

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Product Details of [ 110821-07-3 ]

CAS No. :110821-07-3
Formula : C7H8N2O4
M.W : 184.15
SMILES Code : O=C(C1=CN=C(OC)N=C1OC)O
MDL No. :MFCD03232921

Safety of [ 110821-07-3 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 110821-07-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 110821-07-3 ]

[ 110821-07-3 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 110821-07-3 ]
  • [ 23945-44-0 ]
  • 2
  • [ 67-56-1 ]
  • [ 110821-07-3 ]
  • [ 15400-58-5 ]
YieldReaction ConditionsOperation in experiment
To a suspension of 2,4-Bis(methyloxy)-5-pyrimidinecarboxylic acid (Prep31 , 1.000 g, 5.43 mmol) in N,N-Dimethylformamide (DMF) (35 ml.) at 0 0C N,N'-Carbonyldiimidazole (1.321 g, 8.15 mmol) was added and the mixture was stirred for 1 hour at 0 0C, then left stirring at rt. After 4 h Triethylamine (2.271 ml_, 16.29 mmol) and N,N'-Carbonyldiimidazole (1.321 g, 8.15 mmol), were added to the white suspension. After other 4 h, N, N'- Carbonyldiimidazole (1.321 g, 8.15 mmol) of another batch was added to the suspension. The reaction was left overnight at rt. The solution was then concentrated in vacuo and methanol was added. The solution was stirred at reflux for 2 h. Then the mixture was evaporated in vacuo, the residue was dissolved in DCM and washed with NaHCC>3 sat. sol. and then with H2O. Organic phase was dried with Na2SO4 anhydrous, filtered and evaporated in vacuo to obtain 550 mg of the title compound, which was used in the following step whitout further purification. MS (ES) {mlz): 199.2 [M+H]+.
 

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