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Chemical Structure| 112372-06-2 Chemical Structure| 112372-06-2

Structure of 112372-06-2

Chemical Structure| 112372-06-2

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Product Details of [ 112372-06-2 ]

CAS No. :112372-06-2
Formula : C8H5NO2
M.W : 147.13
SMILES Code : O=CC(O1)=CC2=C1C=NC=C2
MDL No. :MFCD15143904

Safety of [ 112372-06-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P305+P351+P338-P280

Application In Synthesis of [ 112372-06-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 112372-06-2 ]
  • Downstream synthetic route of [ 112372-06-2 ]

[ 112372-06-2 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 112372-06-2 ]
  • [ 112372-15-3 ]
YieldReaction ConditionsOperation in experiment
84% With potassium dihydrogenphosphate; NaClO2 In tetrahydrofuran; water; <i>tert</i>-butyl alcohol C33 (558 mg, 3.79 mmol) is dissolved in 25 mL THF, 12 mL t-butanol, and 12 mL water. KH2PO4 (1.03 g, 7.6 mmol) and NaClO2 (1.28 g, 114 mmol) are added, and the reaction is stirred 3 h at rt.
The reaction is concentrated in vacuo to a residue.
Water (20 mL) is added, and the pH of the mixture is adjusted to 3 with 10percent aqueous HCl.
The mixture is stirred 20 min in an ice bath, the resultant white solid is collected, washed with water and dried to afford furo[2,3-c]pyridine-2-carboxylic acid (C34) (84percent yield). HRMS (FAB) calculated for C8H5NO3+H: 164.0348, found 164.0344 (M+H)+.
References: [1] Patent: US2003/45540, 2003, A1, .
  • 2
  • [ 112372-06-2 ]
  • [ 112372-15-3 ]
References: [1] Journal of Heterocyclic Chemistry, 1987, vol. 24, p. 373 - 376.
 

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