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Chemical Structure| 112969-95-6 Chemical Structure| 112969-95-6

Structure of 112969-95-6

Chemical Structure| 112969-95-6

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Product Details of [ 112969-95-6 ]

CAS No. :112969-95-6
Formula : C6H7NOS
M.W : 141.19
SMILES Code : C=CC(C1=NC=CS1)O

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 112969-95-6 ]

[ 112969-95-6 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 112969-95-6 ]
  • [ 43039-98-1 ]
YieldReaction ConditionsOperation in experiment
64% With sodium hydride In tetrahydrofuran at 0 - 20℃; for 9 h; Inert atmosphere General procedure: To a round-bottom flask that was flame-dried and cooled under nitrogen were added allylic alcohol 51 (0.5 mmol) and THF (2.5 mL). After stirring at 0 °C for 5 min, NaH powder (1 mmol, 2 equiv) was added in one portion, the mixture was then allowed to warm to room temperature. The reaction was quenched by addition of saturated NH4Cl (2 mL) after the indicated time, extracted with EtOAc (10 mL.x.2), and washed by brine (15 mL). The combined organic phase was dried over MgSO4, the solvent was removed under vacuum, and the residue was purified by flash chromatography on silica gel to give the desired ketone product 52.
References: [1] Tetrahedron, 2011, vol. 67, # 19, p. 3406 - 3411.
 

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