Alternatived Products of [ 113618-89-6 ]
Product Details of [ 113618-89-6 ]
CAS No. : | 113618-89-6 |
MDL No. : | MFCD08701375 |
Formula : |
C9H13NO3
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
183.20
|
Pubchem ID : | - |
Synonyms : |
|
Safety of [ 113618-89-6 ]
Application In Synthesis of [ 113618-89-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 113618-89-6 ]
- 1
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[ 113618-89-6 ]
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[ 2510-27-2 ]
Reference:
[1]Journal of Medicinal Chemistry,2014,vol. 57,p. 2773 - 2788
[2]Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences,1901,vol. 132,p. 698
Annales de Chimie (Cachan, France),1902,vol. <7> 26,p. 313
- 2
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[ 113618-89-6 ]
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[ 83467-34-9 ]
Yield | Reaction Conditions | Operation in experiment |
92% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 1h; |
|
2 g |
With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 20℃; for 2h; |
207.207B Example 207B: 2-(3,5-dimethylisoxazol-4-yl)ethanol
To a solution of the product of Example 207A (4.5 g, 24.56 mmol) in tetrahydrofuran (2 mL) was added LiAlH4(1.865 g, 49.1 mmol) in portions at 0 °C. The mixture was stirred at 20 °C for 2 hours before it was quenched at 20 °C by adding water (0.1 mL), an aqueous solution of NaOH (0.1 mL, 15% in water) and water (0.3 mL) successively. The mixture was then filtered, and the filtrate was concentrated under reduced pressure to give the title compound (2 g, 14.2 mmol, 51.9% yield) which was used for the next step without further purification. MS (ESI+) m/z 142 [M+H]+. |
Reference:
[1]Xiao, Xin-Yu; Zhou, Ai-Hua; Shu, Chao; Pan, Fei; Li, Ting; Ye, Long-Wu
[Chemistry - An Asian Journal, 2015, vol. 10, # 9, p. 1854 - 1858]
[2]Current Patent Assignee: GOOGLE INC; ABBVIE INC - WO2020/186199, 2020, A1
Location in patent: Paragraph 00772