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[ CAS No. 1147103-42-1 ]

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Chemical Structure| 1147103-42-1
Chemical Structure| 1147103-42-1
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Product Details of [ 1147103-42-1 ]

CAS No. :1147103-42-1 MDL No. :MFCD21606967
Formula : C10H18ClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :219.71 g/mol Pubchem ID :-
Synonyms :

Safety of [ 1147103-42-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1147103-42-1 ]

  • Upstream synthesis route of [ 1147103-42-1 ]
  • Downstream synthetic route of [ 1147103-42-1 ]

[ 1147103-42-1 ] Synthesis Path-Upstream   1~5

  • 1
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  • [ 1147103-42-1 ]
YieldReaction ConditionsOperation in experiment
70% With hydrogenchloride In ethyl acetate at 30 - 35℃; for 4 h; Inert atmosphere; Cooling with ice The compound A of the present invention can be prepared by deprotecting the amino group according to a conventional method to obtain the prior art intermediate A of telaprevir. In this embodiment, when the amino protecting group P is tert-butoxycarbonyl, The obtained compounds I are exemplified byUnder argon protection,The obtained compound I was slowly added to an ethyl acetate solution (69.9 g) containing 11 wtpercent of hydrogen chloride under an ice bath,After the addition was completed, the temperature was raised to 30-35 ° C, and the reaction was stirred for 4 hours at the temperature to complete the reaction.The reaction solution was concentrated under reduced pressure until no solution was distilled off. The residue was added with methyl tert-butyl ether (80 mL) for 1 hour at room temperature,Suction filtered and the filter cake dried under vacuum to constant weight to give a white to white solid, ie, telmisartan intermediate A: 15.4 g, HPLC purity 99.5percent, total four-step molar yield from compound II to intermediate A It is 70percent
Reference: [1] Patent: CN106928123, 2017, A, . Location in patent: Paragraph 0085-0089
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  • [ 64-17-5 ]
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YieldReaction ConditionsOperation in experiment
71% for 2 h; Reflux The white solid obtained in step (6) was added to 15 L of absolute ethanol, and 2.36 kg of thionyl chloride was added dropwise at room temperature, followed by heating under reflux for 2 hours. After the reaction, the reaction solution was concentrated, The ester was stirred and the precipitated crystals were filtered to give the product 910 g in 71percent yield.
Reference: [1] Patent: CN103664739, 2016, B, . Location in patent: Paragraph 0059-0060
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  • [ 112626-50-3 ]
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Reference: [1] Patent: CN103664739, 2016, B,
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  • [ 402958-16-1 ]
  • [ 1147103-42-1 ]
Reference: [1] Patent: CN106928123, 2017, A,
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  • [ 103871-46-1 ]
  • [ 1147103-42-1 ]
Reference: [1] Patent: CN106928123, 2017, A,
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