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[ CAS No. 1147422-00-1 ]

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Chemical Structure| 1147422-00-1
Chemical Structure| 1147422-00-1
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Product Details of [ 1147422-00-1 ]

CAS No. :1147422-00-1 MDL No. :MFCD11877862
Formula : C12H22N2O2 Boiling Point : 313.8±35.0°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :226.32 g/mol Pubchem ID :49761056
Synonyms :

Safety of [ 1147422-00-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 1147422-00-1 ]

  • Upstream synthesis route of [ 1147422-00-1 ]
  • Downstream synthetic route of [ 1147422-00-1 ]

[ 1147422-00-1 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 148760-75-2 ]
  • [ 1147422-00-1 ]
YieldReaction ConditionsOperation in experiment
100% With 10 wt% Pd(OH)2 on carbon; hydrogen; acetic acid In 2-methoxy-ethanol at 70℃; for 24 h; To a solution of tert-butyl l H-pyrrolo[3,2-c]pyridine-l-carboxylate (2.55 g) in the mixture solvent of glycol monomethyl ether (40 mL) and AcOH (1 mL) was added a catalytic amount of Pd(OH)2/C. The suspension was heated at 70 °C for 24 h under H2 (2.0 MPa) and filtered. The filtrate was concentrated in vacuo andthe residue was chromatographed with a silica gel column (eluting agent: 10: 1 (v/v) CH2Cl2/MeOH) to give the product as viscous liquid (2.64 g, 100.00 percent).
100% With 10 wt% Pd(OH)2 on carbon; hydrogen In acetic acid at 70℃; for 24 h; To a solution of tert-butyl 1H-pyrrolo[3,2-c]pyridine-1-carboxylate (2.55 g) in the mixture solvent of glycol monomethyl ether (40 mL) and AcOH (1 mL) was added a catalytic amount of Pd(OH)2/C. The suspension was heated at 70° C. for 24 h under H2 (2.0 MPa) and filtered. The filtrate was concentrated in vacuo and the residue was chromatographed with a silica gel column (eluting agent: 10:1 (v/v) CH2Cl2/MeOH) to give the product as viscous liquid (2.64 g, 100.00percent).
Reference: [1] Patent: WO2013/71697, 2013, A1, . Location in patent: Paragraph 00276
[2] Patent: US2014/228361, 2014, A1, . Location in patent: Paragraph 0418-0419
  • 2
  • [ 1147421-99-5 ]
  • [ 1147422-00-1 ]
YieldReaction ConditionsOperation in experiment
99% With hydrogen In methanol; ethanol at 20℃; for 10 h; To a solution of (5-benzyl-octahydro-pyrrolo[3,2-c]pyridine-l-carboxylic acid tert- butyl ester (777 mg, 2.46 mmol) in IMS (20 mL) was added palladium hydroxide on carbon(5 percent, 50 mg) and the mixture stirred under a hydrogen atmosphere at RT for 1O h. The reaction mixture was filtered through Celite and the filtrate concentrated in vacuo to give the title compound as a straw coloured oil (550 mg, 99 percent).[M + H]+ 227.3
Reference: [1] Patent: WO2009/53715, 2009, A1, . Location in patent: Page/Page column 75
  • 3
  • [ 24424-99-5 ]
  • [ 1147422-00-1 ]
Reference: [1] Patent: WO2013/71697, 2013, A1,
[2] Patent: US2014/228361, 2014, A1,
  • 4
  • [ 271-34-1 ]
  • [ 1147422-00-1 ]
Reference: [1] Patent: WO2013/71697, 2013, A1,
[2] Patent: US2014/228361, 2014, A1,
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