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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Cbz-Pro-OH (L-Cbz-Proline) is a prolidase inhibitor used to study prolyl aminopeptidase deficiency.
Synonyms: L-Cbz-Proline; Carbobenzoxyproline
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CAS No. : | 1148-11-4 |
Formula : | C13H15NO4 |
M.W : | 249.26 |
SMILES Code : | O=C(O)[C@H]1N(C(OCC2=CC=CC=C2)=O)CCC1 |
Synonyms : |
L-Cbz-Proline; Carbobenzoxyproline
|
MDL No. : | MFCD00003170 |
InChI Key : | JXGVXCZADZNAMJ-NSHDSACASA-N |
Pubchem ID : | 101987 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | To a stirred solution of 13 (10.825 g, 43.43 mmol, 1 eq) in THF was added 1,1?-carbonyldiimidazole (9.365 g, 57.76 mmol, 1.33) and the reaction mixture is stirred for 15 min at room temperature. NaBH4 (2.743 g, 72.52 mmol, 1.67 eq) in 60 mL H2O is added slowly and let it stir for 30 min. Reaction mixtureis quenched with 1N HCl till the pH drops to 2 and the solution is extracted with EtOAc. The combined extracts were washed with aq. NaHCO3, brine, dried over MgSO4 and passed through a short pad of silica to afford yellow oil. Yield 10.116 g, 99%. [alpha]D25 -40.1 (c 1 g/100 mL, CH2Cl2). 1H NMR (400 MHz,CDCl3): delta = 7.39-7.27 (m, 5H), 5.16-5.06 (m, 2H), 4.34-4.03 (bs, 1H), 4.01-3.86 (m, 1H), 3.71-3.57 (d, J= 5.2, 2H), 3.55-3.44 (m, 1H), 3.42-3.32 (m, 1H), 2.04-1.71 (bm, 3H), 1.68-1.55 (m, 1H). 13C NMR (400MHz, CDCl3): delta = 156.88, 136.37, 128.37, 127.92, 127.75, 67.06, 66.51, 60.48, 47.15, 28.37, 23.86. MS(ESI): m/z calcd for [C13H17NO3 + H]+: 236, found: 236. Spectroscopic data agree with literature.25 | |
81% | With dimethylsulfide borane complex; In tetrahydrofuran; dimethylsulfide; at 0 - 20℃; for 8h; | [33.1] To a stirred solution of 1 (benzyloxycarbonyl)-L-proline (15 g) in tetrahydrofuran (150 ml) at 0C., borane-methylsulfide complex (9 ml, 95% in dimethyl sulfide) was added and the reaction mixture was stirred at room temperature for 8 h. At the end of this time the reaction was quenched with 10% AcOH in methanol and the solvent was removed under reduced pressure. The crude product thus obtained was diluted with CHCl3 and washed with water, dried (CaCl2) and the solvent was removed under reduced pressure to get 11.5 g (81 %) of the title compound as a thick liquid. 1H NMR (CDCl3, 200 MHz): d 1.5 -2.2 (m, 4H), 3.3 - 3.8 (m, 4H), 4.0 (m, 1H), 5.15 (s, 2H). 7.36 (bs, 5H). |
75% | General procedure: To a heterogeneous mixture of NaBH4 powder (3.71 mmol) in anhyd THF (15 mL) was added N-protected (S)-proline (S)-7a or (S)-7b (2.32 mmol) at 0 C during 1 h (evolution of H2). BF3·OEt2 (4.64 mmol) was then added and stirring was continued for 4 h, before the addition of 1 N aq NaOH (20 mL). Stirring was continued for 30 min and then the solvent was removed under reduced pressure. EtOAc (30 mL) was added to the residue and the organic layer was washed with 1 N HCl (20 mL) and H2O (20 mL). The organic layer was separated, dried over anhyd Na2SO4, filtered, and concentrated under reduced pressure. The crude product was purified by column chromatography (hexane-EtOAc, 3:1) to afford the corresponding N-protected (S)-prolinol. |
74% | With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 0℃; for 18h;Reflux; | To a solution of Cbz-(S)-proline 7 (10.5 g, 46.25 mmol) in dry THF (100 mL) in a two necked round bottom flask was added NaBH4 (3.98 g, 105.3 mmol) in three portions at 0 C. After stirring the reaction mixture at 0 C for ½ hour, I2 (10.70 g, 42.16 mmol) dissolved in dry THF (25 mL) was added drop wise over a period of 30 min. This solution was refluxed for a period of 18 h till the TLC showed complete disappearance of the starting material. The milky reaction mixture was stirred further for 30 min at room temperature followed by the addition of methanol (50 mL) till a clear solution appears. A white paste was obtained after evaporation under reduced pressure. It was further quenched with 1N HCl and extracted with CH2Cl2 (3 × 20 mL). Column chromatography afforded a colorless gummy liquid Cbz-(S)-prolinol 8 (7.55 g, 74% yield). [alpha]D -41.6 (c 1.73, CHCl3) (lit. -41.8 (c 1.4, CHCl3) [22]); IR (Neat): v 3430, 3033, 2953, 2880, 1680, 1418, 1357, 1192, 1105, 1049, 747, 698 cm-1; 1H NMR (200 MHz, CDCl3): delta 1.60-1.72 (m, 1H), 1.77-2.10 (m, 3H), 3.36-3.45 (m, 1H), 3.50-3.66 (m, 3H), 3.91-4.01 (m, 1H), 4.15-4.27 (br s, 1H), 5.11-5.15 (d, 2H, J = 3.77 Hz), 7.25-7.37 (m, 5H); MS (ESI): m/z (%) = 236 (M + H, 100). |
With acetic acid; In tetrahydrofuran; methanol; dimethylsulfide; | Preparation 4 (2S)-1-(Benzyloxycarbonyl)-2-hydroxymethyl pyrolidine STR39 To a stirred solution of 1(benzyloxycarbonyl)-L-proline (15 g) in tetrahydrofuran (150 ml) at 0 C., borane-methylsulfide complex (9 ml, 95% in dimethyl sulfide) was added and the reaction mixture was stirred at room temperature for 8 h. At the end of this time the reaction was quenched with 10% AcOH in methanol and the solvent was removed under reduced pressure. The crude product thus obtained was diluted with CHCl3 and washed with water, dried (CaCl2) and the solvent was removed under reduced pressure to get 11.5 g (81%) of the title compound as a thick liquid. 1 H NMR (CDCl3, 200 MHz): d 1.5-2.2 (m, 4H), 3.3-3.8 (m, 4H), 4.0 (m, 1H), 5.15 (s, 2H), 7.36 (bs, 5H). | |
In tetrahydrofuran; | 23a. CBZ-L-prolinol To Carbobenzyloxy-L-proline (Aldrich, 9.80 g, 39.3 mmol) in THF (100 mL) at 0 C. was added BH3 -THF complex (Aldrich, 1M in THF, 100 mL, 100 mmol). The mixture was stirred at 0 C. for 2 hours, then at ambient temperature for 16 hr. The reaction mixture was poured into pH 7 phosphate buffer solution (500 mL) and ether (600 mL) and mixed well. The layers were separated and the aqueous portion was extracted with ether (500 mL). The combined organic layers were washed with brine (500 mL), dried (Na2 SO4) and filtered. The solvents were evaporated in vacuo leaving the crude carbobenzyloxy-L-prolinol as an oil (10.5 g). | |
In tetrahydrofuran; | 23a. CBZ-L-prolinol To Carbobenzyloxy-L-proline (Aldrich, 9.80 g, 39.3 mmol)in THF (100 mL) at 0 C. was added BH3 -THF complex (Aldrich, 1M in THF, 100 mL, 100 mmol). The mixture was stirred at 0 C. for 2 hours, then at ambient temperature for 16 hr. The reaction mixture was poured into pH 7 phosphate buffer solution (500 mL) and ether (600 mL) and mixed well. The layers were separated and the aqueous portion was extracted with ether (500 mL). The combined organic layers were washed with brine (500 mL),dried (Na2 SO4) and filtered. The solvents were evaporated in vacuo leaving the crude carbobenzyloxy-L-prolinol as an oil (10.5 g). | |
In tetrahydrofuran; | 23a. CBZ-L-prolinol To Carbobenzyloxy-L-proline (Aldrich, 9.80 g, 39.3 mmol)in THF (100 mL) at 0 C. was added BH3 -THF complex (Aldrich, 1M in THF, 100 mL, 100 mmol). The mixture was stirred at 0 C. for 2 hours, then at ambient temperature for 16 hr. The reaction mixture was poured into pH 7 phosphate buffer solution (500 mL) and ether (600 mL) and mixed well. The layers were separated and the aqueous portion was extracted with ether (500 mL). The combined organic layers were washed with brine (500 mL),dried (Na2 SO4) and filtered. The solvents were evaporated in vacuo leaving the crude carbobenzyloxy-L-prolinol as an oil (10.5g). | |
Reference Example 55 ; L(-)-proline (17.0 g) was dissolved in tetrahydrofuran (350 ml) and a 1 N aqueous sodium hydroxide solution (296 ml), and then benzyl chlorocarbonate (23.2 ml) was added dropwise thereto at 0C under a nitrogen atmosphere. The resulting mixture was returned to room temperature and stirred overnight. 1 N Hydrochloric acid (296 ml) was added thereto at 0C, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was distilled off under reduced pressure to give 1-[(benzyloxy)carbonyl]-L-proline, which was as such dissolved in tetrahydrofuran (250 ml), and then triethylamine (26.8 ml) was added thereto. To the resulting solution was added dropwise ethyl chlorocarbonate (16.9 ml) at 0C under a nitrogen atmosphere. The mixture was returned to room temperature and stirred for 1 hour, and the insolubles were removed by filtration. To the filtrate was added dropwise an aqueous sodium borohydride (11.2 g) solution (100 ml) at 0C, and the mixture was returned to room temperature and stirred for 3 hours under a nitrogen atmosphere. Next, water was added thereto, and the mixture was extracted with ethyl acetate twice. The organic layer was washed with saturated brine. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane : ethyl acetate 2 : 1 ? 1 : 4) to give benzyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (25.0 g) as a colorless oily material. To a solution of oxalyl chloride (6.23 ml) in dichloromethane (70 ml) was added dropwise a solution of dimethyl sulfoxide (10.9 ml) in dichloromethane (100 ml) at -78C under an argon atmosphere. The mixture was stirred as such for 15 minutes, and then a solution of benzyl (2S)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (12.0 g) in dichloromethane (80 ml) was added dropwise thereto. The mixture was stirred as such for 15 minutes, and then triethylamine (42.7 ml) was added dropwise thereto, followed by stirring as such for 20 minutes. The resulting mixture was returned to room temperature and then water was added thereto, followed by separation. The organic layer was washed with 1 N hydrochloric acid twice, an aqueous 4% sodium carbonate solution and saturated brine, respectively, and then dried over magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane : ethyl acetate = 2 : 1 ? 1 : 1) to give benzyl (2S)-2-formylpyrrolidine-1-carboxylate. To [2-(1,3-dioxolan-2-yl)ethyl]triphenylphosphonium bromide (90.4 g) was added tetrahydrofuran (400 ml), further added t-butoxypotassium, and the mixture was stirred at room temperature for 1.5 hours under a nitrogen atmosphere. To the resulting mixture was added dropwise a solution of benzyl (2S)-2-formylpyrrolidine-1-carboxylate in tetrahydrofuran (200 ml), and the mixture was stirred at room temperature for 1 hour and at 50C for 3 hours under a nitrogen atmosphere. After returning to room temperature, water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane : ethyl acetate = 3 : 1 ? 2 : 1) to give benzyl (2S)-2-[3-(1,3-dioxolan-2-yl)-1-propenyl]pyrrolidine-1-carboxylate (15.1 g). Benzyl (2S)-2-[3-(1,3-dioxolan-2-yl)-1-propenyl]pyrrolidine-1-carboxylate (15.0 g) was dissolved in ethanol (200 ml), and then 10% palladium carbon (4.0 g, water content: 50%) was added thereto, followed by overnight stirring at room temperature under a hydrogen atmosphere. The insolubles were removed by filtration, and then the solvent was distilled off under reduced pressure. The resulting residue was dissolved in tetrahydrofuran (200 ml) and a 1 N aqueous sodium hydroxide solution (150 ml), and then benzyl chlorocarbonate (10.1 ml) was added dropwise thereto at 0C under a nitrogen atmosphere. The mixture was returned to room temperature, stirred for 3 hours and extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over magnesium sulfate. The solvent was distilled off under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane : ethyl acetate = 7 : 1) to give benzyl (2R)-2-[3-(1,3-dioxolan-2-yl)propyl]pyrrolidine-1-carboxylate (13.6 g). Benzyl (2R)-2-[3-(1,3-dioxolan-2-yl)propyl]pyrrolidine-1-carboxylate (13.0 g) was dissolved in tetrahydrofuran (130 ml), and then 2 N hydrochloric acid (305 ml) was added thereto at 0C. After stirring the resulting mixture at room temperature for 3.5 hours, a 1 N aqueous sodium hydroxide solution (610 ml) was added thereto at 0C. The mixture was extracted with ethyl acetate, the organic layer was then washed with satur... |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
88% | With sodium hydroxide; sodium borohydrid; In tetrahydrofuran; methanol; | 24c. Alternate preparation of N-Cbz-L-prolinol To a stirred suspension of sodium borohydride (7.59 g, 200 mmol) in 100 mL of THF cooled to 0° C. was added a solution of 20 g (80.28 mmol) of N-Cbz-L-proline, from step 24a above, in 50 mL of ether. To this solution was added dropwise a solution of 5 mL of H2 SO4 in 20 mL of ether, with stirring and while maintaining the temperature below 20° C. The reaction mixture was warmed to room temperature and stirred for 16 hr. The reaction was quenched by the addition of 100 mL of methanol dropwise. The solvents were removed, 30 mL of 4N NaOH was added, and the mixture was extracted with ethyl acetate. The organic extract was dried over Na2 SO4 and concentrated to afford the title product, 16.61 g (88 percent yield). |
88% | With sodium hydroxide; sodium borohydrid; In tetrahydrofuran; methanol; | 24c. Alternate preparation of N-Cbz-L-prolinol To a stirred suspension of sodium borohydride (7.59 g, 200 mmol) in 100 mL of THF cooled to 0° C. was added a solution of 20 g (80.28 mmol) of N-Cbz-L-proline, from step 24a above, in 50 mL of ether. To this solution was added dropwise a solution of 5 mL of H2 SO4 in 20 mL of ether, with stirring and while maintaining the temperature below 20° C. The reaction mixture was warmed to room temperature and stirred for 16 hr. The reaction was quenched by the addition of 100 mL of methanol dropwise. The solvents were removed, 30 mL of 4N NaOH was added, and the mixture was extracted with ethyl acetate. The organic extract was dried over Na2 SO4 and concentrated to afford the title product, 16.61 g (88percent yield). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium borohydrid; sodium hydrogencarbonate; acetic acid; lithium chloride; In tetrahydrofuran; ethanol; water; ethyl acetate; N,N-dimethyl-formamide; | (1) L-N-benzyloxycarbonylprolinol 5 g of L-N-benzyloxycarbonylproline was dissolved in 100 ml of DMF, 8.1 ml of ethyl iodide and 3.4 g of sodium hydrogencarbonate were added thereto. The mixture was stirred at room temperature for 24 hours. Then, water was added to the reaction solution, and extracted with ethyl acetate. The ethyl acetate layer was washed with a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. Then, the solvent was distilled off under reduced pressure. The residue thereby obtained was dissolved in a solvent mixture of 72 ml of ethanol and 48 ml of THF, and reacted at room temperature for two hours by an addition of 2.28 g of sodium borohydride and 2.25 g of lithium chloride. 3.45 ml of acetic acid was added to the reaction solution, and the mixture was concentrated under reduced pressure to dryness. Water and ethyl acetate were added to the residue, and the organic layer was separated, washed with water and with a saturated sodium chloride aqueous solution and dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 3.57 g of the above identified compound as colorless oily substance. Rf: 0.23 (n-hexane/ethyl acetate=1/1). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
77% | To a solution of N-carboxybenzyl-l-proline (8) (200 mg, 0.489 mmol) in anhydrous DMF (18 mL), DIC (0.246 mL, 1.587 mmol) and HOBt (246 mg, 1.587 mmol) were added successively. The reaction mixture was stirred under Ar atmosphere for 1 h at room temperature, and then 7 (370 mg, 0.326 mmol) dissolved in 18 mL of anhydrous DMF was added. The mixture was stirred for 48 h at room temperature. After this time, solvent was evaporated under reduced pressure, and acetone was added over the residue obtained, giving a white precipitate that was filtered and washed with acetone. The precipitate was purified by flash chromatography (MeCN/H2O 7:1). Compound 9 was obtained (0.342 g, 77percent) as a white foam. 1H NMR (300 MHz, DMSO-d6): delta 7.4-7.2 (m, 5H), 5.8-5.6 (m, 14H), 5.2-5.0 (m, 2H), 4.9-4.8 (m, 7H), 4.6-4.4 (m, 6H), 4.3-4.2 (m, 1H), 3.7-3.4 (m, 28H), 3.4-3.2 (m, overlaps with HOD), 2.1-2.0 (m, 2H), 1.9-1.7 (m, 2H); MS (ESI) m/z 1364.9 [M+H]+. Anal. Calcd (percent) for C55H84N2O37: C, 48.39; H, 6.20; N, 2.05. Found: C, 48.68; H, 6.63; N, 1.92. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
98% | With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃; for 12h; | Operation: 5-methoxy-8-amino-quinoline (1.74g, 10mmol), 1 (2.99g, 12mmol), EDCI (2.88g, 15mmol), DMAP (0.12g, 1mmol) were added to 50 ml of CH2Cl2 solution and the reaction mixture was stirred for 12 hours. The reaction solution with HCl (2M) aqueous solution is acidified to PH= 3 and extracted with CH2Cl2(3x50ml) 3 times, the organic layer was treated with saturated salt water (50 ml), after washing, it was dried over anhydrous sodium sulfate. Using petroleum ether: ethyl acetate = 15:1 column to obtain 3.97g compound 2, yield 98%. |
Tags: 1148-11-4 synthesis path| 1148-11-4 SDS| 1148-11-4 COA| 1148-11-4 purity| 1148-11-4 application| 1148-11-4 NMR| 1148-11-4 COA| 1148-11-4 structure
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P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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