14631-43-7|2-Cyanotetrahydrofuran| Ambeed

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Quality Control of [ 14631-43-7 ] Purity: 95% SDS Specification

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Product Details of [ 14631-43-7 ]

CAS No. :	14631-43-7
Formula :	C₅H₇NO
M.W :	97.12
SMILES Code :	N#CC1CCCO1
MDL No. :	MFCD07787008
InChI Key :	RZZIKHSWRWWPAN-UHFFFAOYSA-N
Pubchem ID :	4377949

Safety of [ 14631-43-7 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H301-H311-H331
Precautionary Statements:	P261-P280-P301+P310-P311
Class:	6.1
UN#:	2810
Packing Group:	Ⅲ

Application In Synthesis of [ 14631-43-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 14631-43-7 ]
Downstream synthetic route of [ 14631-43-7 ]

[ 14631-43-7 ] Synthesis Path-Upstream 1~16

1
[ 91470-28-9 ]
[ 14631-43-7 ]

Yield	Reaction Conditions	Operation in experiment
62%	With pyridine; trifluoroacetic anhydride In 1,4-dioxane; chloroform; ethyl acetate	Preparation c-129 Tetrahydro-furan-2-carbonitrile Trifluoroacetic anhydride (1.55 g, 7.38 mmol) was added slowly, with a rate of one drop every 10 seconds, to an ice-cold solution (0° C.) of tetrahydro-furan-2-carboxylic acid amide (0.77 g, 6.71 mmol) and pyridine (1.06 g, 13.42 mmol) in anhydrous 1,4-dioxane (10 mL). The addition of trifluoroacetic anhydride was monitored to keep the internal temperature below 5° C. and was completed after 20 minutes. The resulting mixture was allowed to warm to ambient temperature, and stirred for 3 hours. Chloroform (100 mL) was added to the mixture, and then extracted with water (30 mL) and saturated aqueous sodium chloride (20 mL). The organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (hexanes to 25percent ethyl acetate/hexanes) to afford the title compound (0.51 g, 62percent) as a colorless oil. ¹H NMR (CDCl₃, 300 MHz): 4.70 (1H, m), 3.96 (2H, m), 2.24 (2H, m), 2.08 (2H, m).
62%	With pyridine; trifluoroacetic anhydride In 1,4-dioxane at 5 - 20℃; for 3.33333 h;	Trifluoroacetic anhydride (1. 55 g, 7. 38 MMOL) was added slowly, with a rate of one drop every 10 seconds, to an ice-cold solution (0 °C) of tetrahydro-furan-2- carboxylic acid amide (0. 77 g, 6. 71 MMOL) and pyridine (1. 06 g, 13. 42 MMOL) in anhydrous 1, 4-dioxane (10 mL). The addition of TRIFLUOROACETIC anhydride was monitored to keep the internal temperature below 5 °C and was completed after 20 minutes. The resulting mixture was allowed to warm to ambient temperature, and stirred for 3 hours. Chloroform (100 mL) was added to the mixture, and then extracted with water (30 mL) and saturated aqueous sodium chloride (20 mL). The organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated IN VACUO to give the crude product. The residue was purified by flash column chromatography (hexanes to 25percent ethyl acetate/hexanes) to afford the title compound (0. 51 g, 62percent) as a colorless oil. H NMR (CDCI3, 300 MHz) : 4. 70 (1H, m), 3. 96 (2H, m), 2. 24 (2H, m), 2. 08 (2H, M).

References: [1] Patent: US2005/187266, 2005, A1, .
[2] Patent: WO2004/92145, 2004, A1, . Location in patent: Page 137.

2
[ 38694-47-2 ]
[ 631-57-2 ]
[ 14631-43-7 ]
[ 1393708-93-4 ]

Yield	Reaction Conditions	Operation in experiment
34%	With Candida antarctica lipase B; di-μ-oxo-di((S,S)-N,N'-bis((salicylaldehydo)ethylenediamine))dititanium(IV); water In toluene at 40℃; for 15 h; aq. buffer; Enzymatic reaction	General procedure: Aldehyde (0.24 mmol) and (S,S)-[(salen)Ti(μ-O)]₂ (5 mol percent) were dissolved in toluene (1 mL), and buffer (1 mL) and CALB (20 mg) were added. AcCN (3 equiv diluted to 250 μL with toluene) was added to the organic phase with a constant rate over 24-25 h using a syringe pump. The reaction was monitored by chiral GC using undecane (10 μL, 0.0473 mmol) as internal standard.

References: [1] Tetrahedron, 2012, vol. 68, # 37, p. 7680 - 7684.

3
[ 4795-29-3 ]
[ 14631-43-7 ]

References: [1] Chemistry - A European Journal, 2016, vol. 22, # 15, p. 5156 - 5159.
[2] ACS Catalysis, 2013, vol. 3, # 7, p. 1652 - 1656.

4
[ 109-99-9 ]
[ 172876-96-9 ]
[ 14631-43-7 ]

References: [1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 11, p. 1971 - 1975.

5
[ 1608-67-9 ]
[ 7677-24-9 ]
[ 14631-43-7 ]

References: [1] Tetrahedron, 1983, vol. 39, # 6, p. 961 - 966.
[2] Tetrahedron, 1983, vol. 39, # 6, p. 967 - 974.

6
[ 109-99-9 ]
[ 19158-51-1 ]
[ 14631-43-7 ]

References: [1] Organic Letters, 2011, vol. 13, # 21, p. 5928 - 5931.
[2] Synthesis (Germany), 2013, vol. 45, # 7, p. 874 - 887.

7
[ 13369-70-5 ]
[ 7677-24-9 ]
[ 14631-43-7 ]

References: [1] Tetrahedron, 1983, vol. 39, # 6, p. 961 - 966.

8
[ 13436-45-8 ]
[ 7677-24-9 ]
[ 14631-43-7 ]
[ 86172-03-4 ]

References: [1] Tetrahedron, 1983, vol. 39, # 6, p. 967 - 974.

9
[ 924899-41-2 ]
[ 7677-24-9 ]
[ 14631-43-7 ]

References: [1] Advanced Synthesis and Catalysis, 2006, vol. 348, # 1-2, p. 118 - 124.

10
[ 23247-31-6 ]
[ 14631-43-7 ]

References: [1] Journal of Heterocyclic Chemistry, 1981, vol. 18, p. 565 - 570.

11
[ 1148-11-4 ]
[ 14631-43-7 ]

References: [1] Chemical Science, 2017, vol. 8, # 3, p. 1790 - 1800.

12
[ 172876-96-9 ]
[ 1148-11-4 ]
[ 14631-43-7 ]
[ 119020-06-3 ]

References: [1] Chemical Science, 2017, vol. 8, # 3, p. 1790 - 1800.

13
[ 109-99-9 ]
[ 14631-43-7 ]

References: [1] Chimia, 2017, vol. 71, # 4, p. 226 - 230.

14
[ 91470-28-9 ]
[ 1191-99-7 ]
[ 14631-43-7 ]

References: [1] Journal of the Chemical Society, 1945, p. 52[2] Journal of the American Chemical Society, 1947, vol. 69, p. 3002,3003.

15
[ 23247-31-6 ]
[ 127-09-3 ]
[ 108-24-7 ]
[ 14631-43-7 ]

References: [1] Chemische Berichte, 1927, vol. 60, p. 2511.

16
[ 23247-31-6 ]
[ 127-09-3 ]
[ 64-19-7 ]
[ 14631-43-7 ]

References: [1] Chemische Berichte, 1927, vol. 60, p. 2511.

[ 14631-43-7 ] Synthesis Path-Downstream 1~35

1
[ 14631-43-7 ]
[ 109-99-9 ]
[ 1191-99-7 ]
[ 214262-61-0 ]

References: [1]Journal of the Chemical Society,1945,p. 52.
Journal of the American Chemical Society,1947,vol. 69,p. 3002,3003.

2
[ 14631-43-7 ]
[ 5648-87-3 ]
[ 74-90-8 ]

References: [1]Journal of the Chemical Society,1945,p. 52.
Journal of the American Chemical Society,1947,vol. 69,p. 3002,3003.

3
[ 23247-31-6 ]
[ 127-09-3 ]
[ 108-24-7 ]
[ 14631-43-7 ]

References: [1]Chemische Berichte,1927,vol. 60,p. 2511.

4
[ 23247-31-6 ]
[ 127-09-3 ]
[ 64-19-7 ]
[ 14631-43-7 ]

References: [1]Chemische Berichte,1927,vol. 60,p. 2511.

5
[ 91470-28-9 ]
[ 1191-99-7 ]
[ 14631-43-7 ]

References: [1]Journal of the Chemical Society,1945,p. 52.
Journal of the American Chemical Society,1947,vol. 69,p. 3002,3003.

6
[ 13369-70-5 ]
[ 7677-24-9 ]
[ 14631-43-7 ]

References: [1]Tetrahedron,1983,vol. 39,p. 961 - 966.

7
[ 13436-45-8 ]
[ 7677-24-9 ]
[ 14631-43-7 ]
[ 86172-03-4 ]

References: [1]Tetrahedron,1983,vol. 39,p. 967 - 974.

8
[ 14631-43-7 ]
[ 7103-09-5 ]
[ 79227-31-9 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

9
[ 23247-31-6 ]
[ 14631-43-7 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

10
[ 1608-67-9 ]
[ 7677-24-9 ]
[ 14631-43-7 ]

References: [1]Tetrahedron,1983,vol. 39,p. 961 - 966.
[2]Tetrahedron,1983,vol. 39,p. 967 - 974.

Yield	Reaction Conditions	Operation in experiment
	With phosphorus pentoxide; at 300℃; for 1h;	General procedure: Successive Amide Intermediates Preparation Example A.The reactor is closed (when the amide intermediate has a boiling point equal to or lower than the following reaction temperature TB at normal pressure) or the reaction vessel is left open (when the amide intermediate has a boiling point higher than that of the following Of the reaction temperature TB)),Continue stirring (600r / min),The reaction temperature was changed to TB,After maintaining the reaction temperature TB for TD hours,The reaction is basically completed.then,Close the reactor and connect the vacuum pump,So that the vacuum within the reactor reached 20-50mbar (depending on the type of nitrile products and adjust accordingly)The distillate was used as the nitrile product.The yield of the nitrile product was calculated,Sampling and nuclear magnetic resonance spectroscopy and elemental analysis,To characterize the nitrile product obtained.Specific reaction conditions and characterization results are shown in Tables A-5, A-6, A-7 and A-8 below.These characterization results show that,The nitrile product obtained has an extremely high purity (99% or more).

12
(+-)-tetrahydro-furan-2-carboxylic acid amide [ No CAS ]
[ 14631-43-7 ]

References: [1]Journal of the Chemical Society,1945,p. 52.
Journal of the American Chemical Society,1947,vol. 69,p. 3002,3003.

13
tetrahydrofurfurol oxime [ No CAS ]
[ 14631-43-7 ]

References: [1]Chemische Berichte,1927,vol. 60,p. 2511.

14
[ 924899-41-2 ]
[ 7677-24-9 ]
[ 14631-43-7 ]

References: [1]Advanced Synthesis and Catalysis,2006,vol. 348,p. 118 - 124.

15
[ 784149-40-2 ]
[ 14631-43-7 ]
[ 784149-90-2 ]

Yield	Reaction Conditions	Operation in experiment
46%	With sodium hexamethyldisilazane; In tetrahydrofuran;	Preparation c-130 2-{6-[2-(5-Methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridin-3-ylmethyl}-tetrahydro-furan-2-carbonitrile Sodium bis(trimethylsilyl)amide (1.8 mL, 1.79 mmol) was added to a solution of tetrahydro-furan-2-carbonitrile (0.17 g, 1.79 mmol) in anhydrous tetrahydrofuran (6 mL) under an atmosphere of nitrogen at -78 C. The resulting yellow solution was stirred for 50 minutes, and then a solution of 5-iodomethyl-2-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-pyridine (0.25 g, 0.596 mmol) in anhydrous tetrahydrofuran (3 mL) was added to the enolate solution. The mixture was stirred at -78 C. for 1.5 hours, and quenched with saturated aqueous ammonium chloride (5 mL). The aqueous phase was extracted with ethyl acetate (3*50 mL), and the combined organic extracts washed with water (30 mL), dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (7% to 45% ethyl acetate/hexanes) to afford the title compound (0.11 g, 46%) as a white solid. LRMS (m/z): 390 (M+H)+. 1H NMR (CDCl3, 300 MHz), delta 8.03 (1H, d, J=2.5 Hz), 7.96 (2H, m), 7.56 (1H, dd, J=8.5, 2.5 Hz), 7.40 (3H, m), 6.68 (1H, d, J=8.5 Hz), 4.54 (2H, m), 3.96 (2H, m), 3.00 (4H, m), 2.33 (5H, d, J=3.2 Hz), 1.92 (2H, m).
46%		Sodium bis (trimethylsilyl) amide (1. 8 ML, 1. 79 MMOL) was added to a solution of tetrahydro-furan-2-carbonitrile (0. 17 G, 1. 79 MMOL) in anhydrous tetrahydrofuran (6 mL) under an atmosphere of nitrogen at-78 C. The resulting yellow solution was stirred for 50 minutes, and then a solution of 5-IODOMETHYL-2- [2- (5-METHYL-2-PHENYL- OXAZOL-4-YL)-ETHOXY]-PYRIDINE (0. 25 G, 0. 596 MMOL) in anhydrous tetrahydrofuran (3 mL) was added to the enolate solution. The mixture was stirred at-78 C for 1. 5 hours, and quenched with saturated aqueous ammonium chloride (5 mL). The aqueous phase was extracted with ethyl acetate (3 x 50 mL), and the combined organic extracts washed with water (30 mL), dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (7% to 45% ETHYL ACETATE/HEXANES) to afford the title compound (0. 11 g, 46%) as a white solid. LRMS (m/z) : 390 (M+H) +. H NMR (CDCI3, 300 MHz) ; 8. 03 (1H, d, J= 2. 5 HZ), 7. 96 (2H, m), 7. 56 (1 H, dd, J = 8. 5, 2. 5 Hz), 7. 40 (3H, m), 6. 68 (1H, D, J = 8. 5 Hz), 4. 54 (2H, m), 3. 96 (2H, m), 3. 00 (4H, m), 2. 33 (5H, d, J = 3. 2 HZ), 1. 92 (2H, m).

References: [1]Patent: US2005/187266,2005,A1 .
[2]Patent: WO2004/92145,2004,A1 .Location in patent: Page 137-138.

16
[ 14631-43-7 ]
[ 33964-71-5 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

17
[ 14631-43-7 ]
[ 79227-30-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

18
[ 14631-43-7 ]
[ 79227-30-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

19
[ 14631-43-7 ]
[ 79227-30-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

20
[ 14631-43-7 ]
[ 79227-30-8 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

21
[ 14631-43-7 ]
[ 263355-75-5 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

22
[ 14631-43-7 ]
[ 79227-28-4 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

23
[ 14631-43-7 ]
[ 79227-28-4 ]

References: [1]Journal of Heterocyclic Chemistry,1981,vol. 18,p. 565 - 570.

24
[ 91470-28-9 ]
[ 14631-43-7 ]

Yield	Reaction Conditions	Operation in experiment
62%	With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; chloroform; ethyl acetate;	Preparation c-129 Tetrahydro-furan-2-carbonitrile Trifluoroacetic anhydride (1.55 g, 7.38 mmol) was added slowly, with a rate of one drop every 10 seconds, to an ice-cold solution (0 C.) of tetrahydro-furan-2-carboxylic acid amide (0.77 g, 6.71 mmol) and pyridine (1.06 g, 13.42 mmol) in anhydrous 1,4-dioxane (10 mL). The addition of trifluoroacetic anhydride was monitored to keep the internal temperature below 5 C. and was completed after 20 minutes. The resulting mixture was allowed to warm to ambient temperature, and stirred for 3 hours. Chloroform (100 mL) was added to the mixture, and then extracted with water (30 mL) and saturated aqueous sodium chloride (20 mL). The organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated in vacuo to give the crude product. The residue was purified by flash column chromatography (hexanes to 25% ethyl acetate/hexanes) to afford the title compound (0.51 g, 62%) as a colorless oil. 1H NMR (CDCl3, 300 MHz): 4.70 (1H, m), 3.96 (2H, m), 2.24 (2H, m), 2.08 (2H, m).
62%	With pyridine; trifluoroacetic anhydride; In 1,4-dioxane; at 5 - 20℃; for 3.33333h;	Trifluoroacetic anhydride (1. 55 g, 7. 38 MMOL) was added slowly, with a rate of one drop every 10 seconds, to an ice-cold solution (0 C) of tetrahydro-furan-2- carboxylic acid amide (0. 77 g, 6. 71 MMOL) and pyridine (1. 06 g, 13. 42 MMOL) in anhydrous 1, 4-dioxane (10 mL). The addition of TRIFLUOROACETIC anhydride was monitored to keep the internal temperature below 5 C and was completed after 20 minutes. The resulting mixture was allowed to warm to ambient temperature, and stirred for 3 hours. Chloroform (100 mL) was added to the mixture, and then extracted with water (30 mL) and saturated aqueous sodium chloride (20 mL). The organic extracts were dried (anhydrous magnesium sulfate), filtered, and concentrated IN VACUO to give the crude product. The residue was purified by flash column chromatography (hexanes to 25% ethyl acetate/hexanes) to afford the title compound (0. 51 g, 62%) as a colorless oil. H NMR (CDCI3, 300 MHz) : 4. 70 (1H, m), 3. 96 (2H, m), 2. 24 (2H, m), 2. 08 (2H, M).

References: [1]Patent: US2005/187266,2005,A1 .
[2]Patent: WO2004/92145,2004,A1 .Location in patent: Page 137.

25
[ 109-99-9 ]
[ 19158-51-1 ]
[ 14631-43-7 ]

References: [1]Organic Letters,2011,vol. 13,p. 5928 - 5931.
[2]Synthesis,2013,vol. 45,p. 874 - 887.

26
[ 38694-47-2 ]
[ 631-57-2 ]
[ 14631-43-7 ]
[ 1393708-93-4 ]

Yield	Reaction Conditions	Operation in experiment
28%; 34%	With Candida antarctica lipase B; di-mu-oxo-di((S,S)-N,N'-bis((salicylaldehydo)ethylenediamine))dititanium(IV); water; In toluene; at 40℃; for 15h;pH 6.0;aq. buffer; Enzymatic reaction;	General procedure: Aldehyde (0.24 mmol) and (S,S)-[(salen)Ti(mu-O)]2 (5 mol %) were dissolved in toluene (1 mL), and buffer (1 mL) and CALB (20 mg) were added. AcCN (3 equiv diluted to 250 muL with toluene) was added to the organic phase with a constant rate over 24-25 h using a syringe pump. The reaction was monitored by chiral GC using undecane (10 muL, 0.0473 mmol) as internal standard.

References: [1]Tetrahedron,2012,vol. 68,p. 7680 - 7684.

27
[ 14631-43-7 ]
[ 364596-21-4 ]
[ 1431558-32-5 ]

References: [1]Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,p. 2688 - 2691.

28
[ 4795-29-3 ]
[ 14631-43-7 ]

References: [1]Chemistry - A European Journal,2016,vol. 22,p. 5156 - 5159.
[2]ACS Catalysis,2013,vol. 3,p. 1652 - 1656.

29
[ 14631-43-7 ]
C₅H₁₀N₂O₂ [ No CAS ]

References: [1]ACS Combinatorial Science,2016,vol. 18,p. 616 - 624.

30
[ 14631-43-7 ]
C₈H₁₀N₄O₃S [ No CAS ]

References: [1]ACS Combinatorial Science,2016,vol. 18,p. 616 - 624.

31
[ 14631-43-7 ]
C₈H₈N₄O₂S [ No CAS ]

References: [1]ACS Combinatorial Science,2016,vol. 18,p. 616 - 624.

32
[ 172876-96-9 ]
[ 1148-11-4 ]
[ 14631-43-7 ]
[ 119020-06-3 ]

References: [1]Chemical Science,2017,vol. 8,p. 1790 - 1800.

33
1-cyano-3,3-dimethyl-3-(1H)-1,2-benziodoxole [ No CAS ]
[ 1148-11-4 ]
[ 14631-43-7 ]

References: [1]Chemical Science,2017,vol. 8,p. 1790 - 1800.

34
[ 109-99-9 ]
1-cyano-3,3-dimethyl-3-(1H)-1,2-benziodoxole [ No CAS ]
[ 14631-43-7 ]

References: [1]Chimia,2017,vol. 71,p. 226 - 230.

35
[ 109-99-9 ]
[ 172876-96-9 ]
[ 14631-43-7 ]

References: [1]Organic and Biomolecular Chemistry,2018,vol. 16,p. 1971 - 1975.

Historical Records

Technical Information

• Blaise Reaction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Hydride Reductions • Preparation of Aldehydes and Ketones • Preparation of Amines • Ritter Reaction • Thorpe-Ziegler Reaction

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P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 14631-43-7

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CAS No.: 14631-43-7

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[ 14631-43-7 ] Synthesis Path-Upstream 1~16

[ 14631-43-7 ] Synthesis Path-Downstream 1~35

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