* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
3-Chloro-2-fluoropyridine-4-carbaldehyde (56.1 mg, 0.35 mmol) in tetrahydrofuran (2mL) was mixed with methylmagnesium bromide (0.98 M in tetrahydrofuran, 1.13 mL, 1.05 mmol) under -78C, and the reaction mixture was warmed slowly to room temperature for 16 hours with stirring. After completion of the reaction, the reaction solution was mixed with saturated aqueous ammonium chloride and extracted with ethyl acetate, and the organic layer was dried over anhydrous sodium sulfate and evaporated under reduced pressure. The resulting crude reaction product containing the desired product was used for the next step (64.7 mg) . Morphology: pale yellow oil 1H-NMR(CDCl3) delta: 1.49 (d, J = 6.3 Hz, 1H), 5.27 (q, J = 6.3 Hz, 1H),7.49 (d, J = 5.1 Hz, 1H), 8.08 (d, J = 5.1 Hz, 1H), 10.5 (s, 1H) .
With manganese(IV) oxide; In chloroform; at 80℃; for 24.0h;
A chloroform solution (4 mL) of (3-chloro-2- fluoropyridin-4 -yl) methanol (99.1 mg, 0.61 mmol) was mixed with manganese dioxide (308.6 mg, 3.55 mmol) and stirred at 80C for 1 day. After completion of the reaction, the reaction solution was allowed to cool and filtered through celite, and the filtrate was evaporated under reduced pressure. The resulting containing the desired product was used for the next step (56.1 mg) . Morphology: pale yellow oil 1H-NMR(CDCl3) <n="214"/>delta: 7.64 (d, J = 5.0 Hz, 1H), 8.28 (d, J = 5.0 Hz, 1H), 10.5 (s, 1H)
Chemistry
Pharmaceutical Intermediates
Inhibitors/Agonists
Material Science
Life Science
For Research Only
100K+ Compounds
Competitive Price
1-2 Day Shipping
