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Chemical Structure| 1151564-17-8 Chemical Structure| 1151564-17-8

Structure of 1151564-17-8

Chemical Structure| 1151564-17-8

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Product Details of [ 1151564-17-8 ]

CAS No. :1151564-17-8
Formula : C12H16BClO3
M.W : 254.52
SMILES Code : OC1=CC=CC(B2OC(C)(C)C(C)(C)O2)=C1Cl
MDL No. :MFCD16994269
InChI Key :DUONOXUXQGHBPZ-UHFFFAOYSA-N
Pubchem ID :57374242

Safety of [ 1151564-17-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1151564-17-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 1151564-17-8 ]
  • Downstream synthetic route of [ 1151564-17-8 ]

[ 1151564-17-8 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 1151564-17-8 ]
  • [ 77-78-1 ]
  • [ 1151564-03-2 ]
YieldReaction ConditionsOperation in experiment
85% With potassium carbonate In N,N-dimethyl-formamide at 28 - 55℃; for 0.666667 h; To a stirred solution of 2-chloro-3-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2- yl)-phenol (830 g, 3.26 mol) in dry DMF (4.15 L) was added potassium carbonate(1126.4 g, 8.15 mol) under an inert atmosphere. Me2SO4 (402 mL, 4.24 mol) was added slowly to control the resulting exotherm (addition over 30 minutes gave a temperature rise from 28 0C to 55 0C) and after complete addition the reaction was stirred for 10 minutes. The reaction mixture was added to stirring HCl (5.98 L, 2 N, aq.) very slowly to control effervescence and the resulting precipitate stirred for 2 hours. The solids were filtered and washed with water (1 L) and dried in a vacuum oven over drying agent for 4 days to give 2-(2-chloro-3-methoxy-phenyl)-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane 7a as a white powder (746.7 g, 2.78 mol, 85 percent).
References: [1] Patent: WO2009/62087, 2009, A1, . Location in patent: Page/Page column 23.
 

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[ 1151564-17-8 ]

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