115377-93-0|2-(Methoxymethoxy)phenylboronic acid| Ambeed

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Quality Control of [ 115377-93-0 ] Purity: 98% SDS Specification

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Product Details of [ 115377-93-0 ]

CAS No. :	115377-93-0
Formula :	C₈H₁₁BO₄
M.W :	181.98
SMILES Code :	COCOC1=CC=CC=C1B(O)O
MDL No. :	MFCD10566597

Safety of [ 115377-93-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 115377-93-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 115377-93-0 ]

[ 115377-93-0 ] Synthesis Path-Downstream 1~35

1
[ 201230-82-2 ]
[ 100-39-0 ]
[ 115377-93-0 ]
[ 153870-76-9 ]

References: [1]Tetrahedron Letters,1993,vol. 34,p. 7595 - 7598.
[2]Journal of Organic Chemistry,1998,vol. 63,p. 4726 - 4731.

2
[ 115377-93-0 ]
[ 263718-59-8 ]
[ 263718-68-9 ]

References: [1]Heterocycles,2000,vol. 52,p. 719 - 732.

3
[ 121-43-7 ]
[ 824-91-9 ]
[ 115377-93-0 ]
C₁₆H₁₉BO₅ [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

4
[ 115377-93-0 ]
[ 724707-84-0 ]
C₁₆H₁₉BO₅ [ No CAS ]
(+)-2-menthenylphenyl methoxymethyl ether [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

5
[ 115377-93-0 ]
[ 588717-66-2 ]
5-methoxymethoxy-6-(2-methoxymethoxy-phenyl)-tricyclo[8.2.2.2^4,7]hexadeca-1⁽¹³⁾,4⁽¹⁶⁾,5,7⁽¹⁵⁾,10⁽¹⁴⁾,11-hexaene [ No CAS ]

References: [1]Tetrahedron Letters,2003,vol. 44,p. 3801 - 3804.

6
3-bromo-2-methoxymethoxy-2'-phenyl-[1,1']binaphthalenyl [ No CAS ]
[ 115377-93-0 ]
2-methoxymethoxy-3-(2-methoxymethoxy-phenyl)-2'-phenyl-[1,1']binaphthalenyl [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2004,vol. 2,p. 3312 - 3319.

7
(S)-3-bromo-2-methoxymethoxy-2'-β-naphthyl-1,1'-binaphthyl [ No CAS ]
[ 115377-93-0 ]
2-methoxymethoxy-3-(2-methoxymethoxy-phenyl)-[1,1';2',2'']ternaphthalene [ No CAS ]

References: [1]Organic and Biomolecular Chemistry,2004,vol. 2,p. 3312 - 3319.

8
[ 115377-93-0 ]
(+)-2-neomenthylphenol [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

9
[ 115377-93-0 ]
1-((1R,2R,5S)-2-Isopropyl-5-methyl-cyclohexyl)-2-methoxymethoxy-benzene [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

10
[ 115377-93-0 ]
(+)-2,4-dibromo-6-neomenthylphenol [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

11
[ 115377-93-0 ]
C₁₈H₂₇BO₄ [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

12
[ 115377-93-0 ]
(+)-2,6-dimenthenylphenol [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

13
[ 115377-93-0 ]
1,3-Bis-((3S,6R)-6-isopropyl-3-methyl-cyclohex-1-enyl)-2-methoxymethoxy-benzene [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

14
[ 115377-93-0 ]
C₃₆H₅₁BO₅ [ No CAS ]

References: [1]Bulletin of the Chemical Society of Japan,2001,vol. 74,p. 1445 - 1454.

15
[ 115377-93-0 ]
(S)-2-(1-Ethyl-propylamino)-2-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethanol [ No CAS ]

References: [1]Heterocycles,2000,vol. 52,p. 719 - 732.

16
[ 115377-93-0 ]
[ 263718-69-0 ]

References: [1]Heterocycles,2000,vol. 52,p. 719 - 732.

17
[ 115377-93-0 ]
(S)-3-(1-Ethyl-propyl)-4-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-oxazolidin-2-one [ No CAS ]

References: [1]Heterocycles,2000,vol. 52,p. 719 - 732.

18
[ 115377-93-0 ]
{2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-1-[6-(2-methoxymethoxy-phenyl)-pyridin-2-yl]-ethyl}-(1-ethyl-propyl)-amine [ No CAS ]

References: [1]Heterocycles,2000,vol. 52,p. 719 - 732.

19
[ 115377-93-0 ]
[ 574-12-9 ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 4726 - 4731.

20
[ 115377-93-0 ]
[ 2491-31-8 ]

References: [1]Journal of Organic Chemistry,1998,vol. 63,p. 4726 - 4731.

21
[ 68314-54-5 ]
[ 115377-93-0 ]

Yield	Reaction Conditions	Operation in experiment
		(b) 2-Methoxymethoxyphenylboronic Acid. In a manner similar to that of Example 1(a), starting with 19.00 g (8.7 mmol) of 2-methoxymethoxybromobenzene, 11.00 g (70%) of the expected product are obtained in the form of a white solid with a melting point of 63-66 C. 1H NMR (CDCl3) δ 3.51 (s, 3H), 5.31 (s, 2H), 6.21 (s, 2H), 7.07 (d, 1H, J=7.3 Hz), 7.14 (d, 1H, J=8.8 Hz), 7.43 (dt, 1H, J=8.6/1.9 Hz), 7.87 (dd, 1H, J=7.3/1.8 Hz).

References: [1]Journal of Molecular Structure,2009,vol. 920,p. 430 - 435.
[2]Patent: US6316009,2001,B1 .

Yield	Reaction Conditions	Operation in experiment
		EXAMPLE 108 3-[4-((3aR,9bR)-cis-9-Methoxy-1,2,3,3a,4,9b-hexahydro-[1]-benzopyrano[3,4-c]pyrrol-2-yl)butyl]-8-(4-hydroxyphenyl)-pyrazzino[2',3':4,5]thieno[3,2-d]pyrmidine-2,4(1H,3H)-dione The product of Example 16 (0.07 g,0.105 mmol) and 4 (methoxymethyloxy) phenyl boronic acid (0.02 g, 0.11 mmol) prepared by the procedure described in Tetr. Lett., 31, 27, (1990) were treated as described in Example 106 to yield 0.029 g (45%) of MOM-protected product.

23
[ 150-46-9 ]
[ 68314-54-5 ]
[ 7664-93-9 ]
[ 115377-93-0 ]

References: [1]Journal of Molecular Structure,2009,vol. 920,p. 430 - 435.

24
[ 115377-93-0 ]
[ 320749-00-6 ]
[ 1372559-96-0 ]

References: [1]Israel Journal of Chemistry,2012,vol. 52,p. 156 - 170.

25
[ 4408-64-4 ]
[ 115377-93-0 ]
[ 1613586-42-7 ]

References: [1]Advanced Synthesis and Catalysis,2014,vol. 356,p. 1767 - 1772.

26
[ 115377-93-0 ]
[ 1613586-35-8 ]

References: [1]Advanced Synthesis and Catalysis,2014,vol. 356,p. 1767 - 1772.

27
[ 115377-93-0 ]
[ 21849-91-2 ]

References: [1]Advanced Synthesis and Catalysis,2014,vol. 356,p. 1767 - 1772.

28
methyl 2-bromo-8-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-9-methoxypyrrolo[2,1-a]isoquinoline-3-carboxylate [ No CAS ]
[ 115377-93-0 ]
methyl 8-isopropoxy-1-(3-isopropoxy-4-methoxyphenyl)-9-methoxy-2-[2-(methoxymethoxy)phenyl]pyrrolo[2,1-a]isoquinoline-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
94%	With 1,1'-bis-(diphenylphosphino)ferrocene; sodium carbonate; bis(dibenzylideneacetone)-palladium(0); In 1,2-dimethoxyethane; water; at 85℃; for 24h;Inert atmosphere; Sealed tube;	Under an argon atmosphere, a mixture of 7(50.0 mg, 89.9 lmol), 8a (24.6 mg, 0.135 mmol), Pd(dba)2 (5.2mg, 9.0 lmol), dppf (5.0 mg, 9.0 lmol), Na2CO3 (63.0 mg, 0.594mmol), DME (3.0 mL), and degassed water (0.2 mL) was heatedin a sealed tube at 85 C for 24 h. After cooling to room temperature,the mixture was evaporated and the products were extractedwith DCM. The extract was washed with water and brine, driedover Na2SO4, and evaporated. The residue was purified by flash chromatography over silica gel 60N (hexane-ethyl acetate = 4:1)to give 9a as a pale yellow solid (51.8 mg, 94%). Recrystallization from DCM-hexane gave a pale yellow needles. Mp 186-187 C. IR (KBr): 1688, 1473, 1379, 1256, 1226, 1190, 1114 cm1. 1H NMR(400 MHz, CDCl3): d 1.07 (d, J = 6.1 Hz, 1.5H), 1.20 (d, J = 6.1 Hz,1.5H), 1.21 (d, J = 6.1 Hz, 1.5H), 1.27 (d, J = 6.1 Hz, 1.5H), 1.42 (d,J = 6.1 Hz, 6H), 3.30 (s, 3H), 3.42 (br s, 3H), 3.59 (s, 3H), 3.81 (s,1.5H), 3.82 (s, 1.5H), 4.25 (sep, J = 6.1 Hz, 0.5H), 4.33 (sep, J = 6.1Hz, 0.5H), 4.66 (sep, J = 6.1 Hz, 1H), 4.86 (d, J = 6.9 Hz, 0.5H), 4.96(d, J = 6.9 Hz, 0.5H), 4.99 (d, J = 6.9 Hz, 0.5H), 5.04 (d, J = 6.9 Hz,0.5H), 6.75-6.89 (m, 4H), 6.93 (d, J = 7.6 Hz, 1H), 6.95-7.01 (m,1H), 7.04 (s, 1H), 7.08 (d, J = 8.3 Hz, 1H), 7.11-7.21 (m, 2H), 9.30(d, J = 7.6 Hz, 1H). 13C NMR (100 MHz, CDCl3): d 21.7, 21.8, 21.9,21.9, 22.0, 22.2, 50.7, 55.3, 55.7, 56.0, 71.1, 71.1, 71.2, 95.1,105.6, 110.6, 111.4, 111.7, 112.0, 112.8, 114.6, 117.4, 118.1,118.2, 118.6, 119.0, 119.4, 119.8, 121.0, 121.2, 123.5, 123.9,124.1, 124.2, 124.4, 128.2, 128.3, 128.4, 130.4, 131.4, 131.8,132.3, 132.4, 146.9, 147.5, 148.5, 149.3, 149.9, 150.4, 155.6, 162.6. HRDARTMS m/z. Calcd for C36H40NO8 [(M+H)+]: 614.27539.Found: 614.27399.

References: [1]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6563 - 6580.

29
[ 121-43-7 ]
[ 68314-54-5 ]
[ 7732-18-5 ]
[ 115377-93-0 ]

Yield	Reaction Conditions	Operation in experiment
71%		Under an argon atmosphere, apentane solution of tert-butyllithium (1.52 M, 14.4 mL, 21.9 mmol) was added dropwise to a solution of S1 (2.38 g, 11.0 mmol) in THF (30 mL) at -78 C. After stirring for 1 h at -78 C, trimethyl borate (1.84 mL, 16.5 mmol) was added as a neat liquid and the mixture was stirred for 1 h at -78 C. The reaction mixture was allowed to warmto room temperature and stirred for an additional 1 h. The mixture was quenched with saturatedaqueous NH4Cl and concentrated. The products were adjusted to pH 3 with acetic acid and themixture was extract with dichloromethane. The extract was washed successively with water and brine, dried over Na2SO4, and evaporated. The residue was washed with hexane and dried underreduced pressure to give 8a as a colorless powder (1.41 g, 71%). This compound was used for thenext reaction without further purification.

References: [1]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6563 - 6580.

30
[ 95-56-7 ]
[ 115377-93-0 ]

References: [1]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6563 - 6580.

31
[ 115377-93-0 ]
11-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-12-methoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6563 - 6580.

32
[ 115377-93-0 ]
11-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-12-methoxy-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one [ No CAS ]

References: [1]Bioorganic and Medicinal Chemistry,2017,vol. 25,p. 6563 - 6580.

33
benzyl 9-(3-amino-6-chloropyridazin-4-yl)-1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate [ No CAS ]
[ 115377-93-0 ]
benzyl 9-[3-amino-6-[2-(methoxymethoxy)phenyl]pyridazin-4-yl]-1-oxa-4,9-diazaspiro[5.5]undecane-4-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
83%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water; at 100℃; for 2h;	Into a 30-mL sealed tube, was placed benzyl 9-(3-amino-6-chloropyridazin-4-yl)-1-oxa-4, 9-diazaspiro[5.5]undecane-4-carboxylate (3.1 g, 7.4 mmol, 1.0 equiv), [2-(methoxymethoxy) phenyl]boronic acid (2.7 g, 0.1 mmol, 2.0 equiv), Pd(PPh3)4 (859.4 mg, 0.7 mmol, 0.1 equiv), and K2CO3 (3.1 g, 0.1 mmol, 3.0 equiv) in dioxane (5 mL) and H2O (1 mL). The resulting mixture was stirred for 12 hours at 100 C. in an oil bath, and then was extracted with ethyl acetate (20 mL*2). The combined organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was applied onto a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 3.2 g (83%) of benzyl 9-[3-amino-6-[2-(methoxymethoxy) phenyl]pyridazin-4-yl]-1-oxa-4, 9-diazaspiro[5.5]undecane-4-carboxylate as a yellow solid.

References: [1]Patent: US2019/300521,2019,A1 .Location in patent: Paragraph 1396-1397.

34
2-(3-[4-[3-(3-amino-6-chloropyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]propoxy)ethan-1-ol [ No CAS ]
[ 115377-93-0 ]
2-[3-[4-(3-[3-amino-6-[2-(methoxymethoxy)phenyl]pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridin-2-yl]propoxy]ethan-1-ol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water;Inert atmosphere; Heating;	Into a 50-mL round-bottom flask purged and maintained under an inert atmosphere of nitrogen, was placed 2-(3-[4-[3-(3-amino-6-chloropyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]propoxy)ethan-1-ol (650 mg, 1.55 mmol, 1.00 equiv), [2-(methoxymethoxy)phenyl]boronic acid (566 mg, 3.11 mmol, 2.00 equiv), dioxane (8 mL), water (2 mL), potassium carbonate (644 mg, 4.66 mmol, 3.00 equiv), Pd(PPh3)4 (180 mg, 0.16 mmol, 0.10 equiv). The resulting solution was stirred for 3 hours at 100 C. in an oil bath. The resulting mixture was concentrated under vacuum. The residue was applied onto a silica gel column with methanol/H2O (85:15). The collected fractions were combined and concentrated under vacuum. This resulted in 400 mg (50%) of 2-[3-[4-(3-[3-amino-6-[2-(methoxymethoxy)phenyl]pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridin-2-yl]propoxy]ethan-1-ol as yellow oil.

References: [1]Patent: US2019/300521,2019,A1 .Location in patent: Paragraph 0740-0741.

35
benzyl 4-[2-([4-[3-(3-amino-6-chloropyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxy)ethyl]piperazine-1-carboxylate [ No CAS ]
[ 115377-93-0 ]
benzyl 4-(2-[[4-(3-[3-amino-6-[2-(methoxymethoxy)phenyl]pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridin-2-yl]oxy]ethyl)piperazine-1-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
26%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In 1,4-dioxane; water;Heating;	Into a 100-mL round-bottom flask, was placed benzyl 4-[2-([4-[3-(3-amino-6-chloropyridazin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl]pyridin-2-yl]oxy)ethyl]piperazine-1-carboxylate (390 mg, 0.7 mmol, 1.0 equiv), dioxane (8.0 mL), water (2.0 mL), potassium carbonate (279 mg, 2.0 mmol, 3.0 equiv), [2-(methoxymethoxy)phenyl]boronic acid (184.0 mg, 1.0 mmol, 1.50 equiv), Pd(PPh3)4 (78 mg, 0.07 mmol, 0.1 equiv). The resulting solution was stirred for 2 hours at 100 C. The resulting solution was extracted with ethyl acetate (20 mL*3), and the organic layers combined and concentrated under vacuum. The residue was applied onto a silica gel column eluting with dichloromethane/methanol (10:1). This resulted in 120 mg (26%) of benzyl 4-(2-[[4-(3-[3-amino-6-[2-(methoxymethoxy)phenyl]pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl)pyridin-2-yl]oxy]ethyl)piperazine-1-carboxylate as a brown solid.

References: [1]Patent: US2019/300521,2019,A1 .Location in patent: Paragraph 0790-0791.

Historical Records

Technical Information

• Nomenclature of Ethers • Preparation of Ethers • Reactions of Benzene and Substituted Benzenes • Reactions of Ethers

Related Functional Groups of
[ 115377-93-0 ]

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P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 115377-93-0

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