Home Cart Sign in  
Chemical Structure| 1160790-50-0 Chemical Structure| 1160790-50-0

Structure of 1160790-50-0

Chemical Structure| 1160790-50-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 1160790-50-0 ]

CAS No. :1160790-50-0
Formula : C17H26BN3O4
M.W : 347.22
SMILES Code : O=C(C1CCN(C2=NC=C(B3OC(C)(C)C(C)(C)O3)C=N2)CC1)OC
MDL No. :MFCD18261492
InChI Key :UEKXCFIPAGCLQJ-UHFFFAOYSA-N
Pubchem ID :57416468

Safety of [ 1160790-50-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 1160790-50-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1160790-50-0 ]

[ 1160790-50-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 914347-01-6 ]
  • [ 73183-34-3 ]
  • [ 1160790-50-0 ]
YieldReaction ConditionsOperation in experiment
A solution of methyl-1-(5-bromopyrimidin-2-yl)piperidine-4-carboxylate (0.32 g, 1.05 mmol), bispinacolatodiboron (0.32 g, 1.25 mmol) and KOAc (0.16 g, 1.60 mmol) in 1 ,4-dioxane (5.0 mL) was degassed by flushing with nitrogen for 15 min. Tricyclohexylphosphine (0.036 g, 0.13 mmol) and tris(dibenzyledineacetone) dipalladium (0) (0.05 g, 0.053 mmol) was then added to the reaction mixture, which was again degassed by nitrogen for 15 min. The resulting reaction mixture was heated to 1000C for 4 h. After the completion of the reaction (TLC monitoring), the reaction mixture was filtered through celite bed and the filtrate was concentrated to get the crude residue that was carried forward to the next step without further purification. MS: 348.21 (M+H)+.
900 mg With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 90℃; for 12h;Inert atmosphere; A mixture of methyl l-(5-bromopyrimidin-2-yl)piperidine-4-carboxylate (1.0 g, 3.33 mmol, 1 eq), bis(pinacolato)diboron (1.69 g, 6.66 mmol, 2 eq), potassium acetate (0.98 g, 10 mmol, 3 eq) and Pd(dppf)C12 (0.24 g, 0.330 mmol, 0.100 eq) in 1,4-dioxane (20 mL) was purged with N2 for 3 times, and the mixture was stirred at 90 C for 12 hours under N2 atmosphere. The reaction mixture was filtered and the filtrate was concentrated in vacuo. Purification by prep-HPLC gave the title compound (900 mg, 2.59 mmol, 77.8% yield) as a yellow solid.
 

Historical Records

Technical Information

Categories